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- W4376132406 startingPage "4439" @default.
- W4376132406 abstract "The binding of ligands to receptors within a nanoscale small space is relevant in biology, biosensing, and affinity filtration. Binding in confinement can be studied with biological systems but under the limitation that essential parameters cannot be easily controlled including receptor type and position within the confinement and its dimensions. Here we study molecular recognition with a synthetic confined nanopore with controllable pore dimension and molecular DNA receptors at different depth positions within the channel. Binding of a complementary DNA strand is studied at the single-molecule level with atomic force microscopy. Following the analysis, kinetic association rates are lower for receptors positioned deeper inside the pore lumen while dissociation is faster and requires less force. The phenomena are explained by the steric constraints on molecular interactions in confinement. Our study is the first to explore recognition in DNA nanostructures with atomic force microscopy and lays out new tools to further quantify the effect of nanoconfinement on molecular interactions." @default.
- W4376132406 created "2023-05-12" @default.
- W4376132406 creator A5017921654 @default.
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- W4376132406 creator A5074203617 @default.
- W4376132406 creator A5079747412 @default.
- W4376132406 creator A5089105218 @default.
- W4376132406 date "2023-05-11" @default.
- W4376132406 modified "2023-10-14" @default.
- W4376132406 title "Molecular Recognition in Confined Space Elucidated with DNA Nanopores and Single-Molecule Force Microscopy" @default.
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