FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376133013> ?p ?o ?g. }

• W4376133013 abstract "Atrial fibrillation (AF) is the commonest cardiac arrhythmia, affecting 3 million people in the USA and 8 million in the EU (according to the European Society of Cardiology). So, why is it that even with the best medical care, around a third of the patients are treatment resistant. Extensive research of its etiology showed that AF and its mechanisms are still debatable. Some of the AF origins are ascribed to functional and ionic heterogeneities of the heart tissue and possibly to additional triggering agents. But, have all AF origins been detected? Are all accepted origins, in fact, arrhythmogenic? In order to study these questions and specifically to check our new idea of intermittency as an arrhythmogenesis agent, we chose to employ a mathematical model which was as simple as possible, but which could still be used to observe the basic network processes of AF development. At this point we were not interested in the detailed ionic propagations nor in the actual shapes of the induced action potentials (APs) during the AF outbreaks. The model was checked by its ability to exactly recapture the basic AF developmental stages known from experimental cardiac observations and from more elaborate mathematical models. We use a simple cellular automata 2D mathematical model of N × N matrices to elucidate the field processes leading to AF in a tissue riddled with randomly distributed heterogeneities of different types, under sinus node operation, simulated by an initial line of briefly stimulated cells inducing a propagating wave, and with or without an additional active ectopic action potential pulse, in turn simulated by a transitory operation of a specific cell. Arrhythmogenic contributions, of three different types of local heterogeneities in myocytes and their collaborations, in inducing AF are examined. These are: a heterogeneity created by diffuse fibrosis, a heterogeneity created by myocytes having different refractory periods, and a new heterogeneity type, created by intermittent operation of some myocytes. The developmental stages (target waves and spirals) and the different probabilities of AF occurring under each condition, are shown. This model was established as being capable of reproducing the known AF origins and their basic development stages, and in addition has shown: (1) That diffuse fibrosis on its own is not arrhythmogenic but in combination with other arrhythmogenic agents it can either enhance or limit AF. (2) In general, combinations of heterogeneities can act synergistically, and, most importantly, (3) The new type of intermittency heterogeneity proves to be extremely arrhythmogenic. Both the intermittency risk and the fibrosis role in AF generation were established. Knowledge of the character of these arrhythmogenesis agents can be of real importance in AF treatment." @default.
• W4376133013 created "2023-05-12" @default.
• W4376133013 creator A5002746304 @default.
• W4376133013 creator A5014926698 @default.
• W4376133013 creator A5067882145 @default.
• W4376133013 creator A5078524412 @default.
• W4376133013 creator A5083670089 @default.
• W4376133013 date "2023-05-10" @default.
• W4376133013 modified "2023-09-26" @default.
• W4376133013 title "A possible new cardiac heterogeneity as an arrhythmogenic driver" @default.
• W4376133013 cites W1850125129 @default.
• W4376133013 cites W1965864004 @default.
• W4376133013 cites W1977859104 @default.
• W4376133013 cites W1995324236 @default.
• W4376133013 cites W20074729 @default.
• W4376133013 cites W2061518199 @default.
• W4376133013 cites W2071675848 @default.
• W4376133013 cites W2097173178 @default.
• W4376133013 cites W2139245232 @default.
• W4376133013 cites W2139851328 @default.
• W4376133013 cites W2206522772 @default.
• W4376133013 cites W2280393564 @default.
• W4376133013 cites W2299357518 @default.
• W4376133013 cites W2313136205 @default.
• W4376133013 cites W2313203550 @default.
• W4376133013 cites W2468961432 @default.
• W4376133013 cites W2535611644 @default.
• W4376133013 cites W2560879934 @default.
• W4376133013 cites W2612635084 @default.
• W4376133013 cites W2615881321 @default.
• W4376133013 cites W2754086446 @default.
• W4376133013 cites W2789877759 @default.
• W4376133013 cites W2912836197 @default.
• W4376133013 cites W2941064501 @default.
• W4376133013 cites W2944911353 @default.
• W4376133013 cites W2953516971 @default.
• W4376133013 cites W2966633756 @default.
• W4376133013 cites W2969852609 @default.
• W4376133013 cites W2971803625 @default.
• W4376133013 cites W2983879864 @default.
• W4376133013 cites W2999685931 @default.
• W4376133013 cites W3007670977 @default.
• W4376133013 cites W3028594427 @default.
• W4376133013 cites W3153519718 @default.
• W4376133013 cites W3165450533 @default.
• W4376133013 cites W3186541360 @default.
• W4376133013 cites W4200495872 @default.
• W4376133013 cites W4214540713 @default.
• W4376133013 cites W4295793791 @default.
• W4376133013 doi "https://doi.org/10.1038/s41598-023-33438-y" @default.
• W4376133013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37165085" @default.
• W4376133013 hasPublicationYear "2023" @default.
• W4376133013 type Work @default.
• W4376133013 citedByCount "0" @default.
• W4376133013 crossrefType "journal-article" @default.
• W4376133013 hasAuthorship W4376133013A5002746304 @default.
• W4376133013 hasAuthorship W4376133013A5014926698 @default.
• W4376133013 hasAuthorship W4376133013A5067882145 @default.
• W4376133013 hasAuthorship W4376133013A5078524412 @default.
• W4376133013 hasAuthorship W4376133013A5083670089 @default.
• W4376133013 hasBestOaLocation W43761330131 @default.
• W4376133013 hasConcept C111472728 @default.
• W4376133013 hasConcept C121332964 @default.
• W4376133013 hasConcept C138885662 @default.
• W4376133013 hasConcept C164705383 @default.
• W4376133013 hasConcept C169760540 @default.
• W4376133013 hasConcept C2779161974 @default.
• W4376133013 hasConcept C2780586882 @default.
• W4376133013 hasConcept C2780791683 @default.
• W4376133013 hasConcept C2988455589 @default.
• W4376133013 hasConcept C41008148 @default.
• W4376133013 hasConcept C62520636 @default.
• W4376133013 hasConcept C62611344 @default.
• W4376133013 hasConcept C71924100 @default.
• W4376133013 hasConcept C86803240 @default.
• W4376133013 hasConceptScore W4376133013C111472728 @default.
• W4376133013 hasConceptScore W4376133013C121332964 @default.
• W4376133013 hasConceptScore W4376133013C138885662 @default.
• W4376133013 hasConceptScore W4376133013C164705383 @default.
• W4376133013 hasConceptScore W4376133013C169760540 @default.
• W4376133013 hasConceptScore W4376133013C2779161974 @default.
• W4376133013 hasConceptScore W4376133013C2780586882 @default.
• W4376133013 hasConceptScore W4376133013C2780791683 @default.
• W4376133013 hasConceptScore W4376133013C2988455589 @default.
• W4376133013 hasConceptScore W4376133013C41008148 @default.
• W4376133013 hasConceptScore W4376133013C62520636 @default.
• W4376133013 hasConceptScore W4376133013C62611344 @default.
• W4376133013 hasConceptScore W4376133013C71924100 @default.
• W4376133013 hasConceptScore W4376133013C86803240 @default.
• W4376133013 hasIssue "1" @default.
• W4376133013 hasLocation W43761330131 @default.
• W4376133013 hasLocation W43761330132 @default.
• W4376133013 hasOpenAccess W4376133013 @default.
• W4376133013 hasPrimaryLocation W43761330131 @default.
• W4376133013 hasRelatedWork W1967841144 @default.
• W4376133013 hasRelatedWork W2018480046 @default.
• W4376133013 hasRelatedWork W2064495796 @default.
• W4376133013 hasRelatedWork W2319489406 @default.
• W4376133013 hasRelatedWork W2333279585 @default.
• W4376133013 hasRelatedWork W2603808924 @default.

• next