FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376133084> ?p ?o ?g. }

• W4376133084 endingPage "4948" @default.
• W4376133084 startingPage "4932" @default.
• W4376133084 abstract "Our objective was to develop a sole ulcer (SU) induction model that can be used to investigate new and more efficacious methods for the treatment and prevention of SU. Three iterations [phase (P)1, P2, and P3] of an SU induction model designed to mimic mechanical and presumed metabolic pathways for SU development were conducted. The results from P1 and P2 identified alterations for the subsequent phase. Each phase used cows with similar calving dates that were randomly assigned (n = 4) to treatments. Control cows (P1CON, P3CON) did not undergo any challenges to induce SU development. Treatment cows were challenged with a hoof block (B) applied to the right hind lateral hoof. Other treatments included restricted lying time (L), restricted feed intake (F), or systemic lipopolysaccharide (LPS) administration. Treatment comparisons were P1CON versus P1BL, P2B versus P2BL, and P3CON versus P3BLF and P3BLF+LPS for P1, P2, and P3, respectively. Pregnant nulliparous Holstein cows were used in P1 and P3, and the P1 cohort was used in P2 during mid-lactation [125.9 ± 7.20 d in milk (DIM)]. Challenges were applied during a set challenge period (P1: −14 to 14 DIM, P2: 126–168 DIM, P3: −14 to 28 DIM). The P1BL cows had a hoof block applied and lying time restricted for 5 h/d. The P2B and P2BL cows had a hoof block and P2BL cows also had their lying time restricted for 18 h/d for 2 d/wk. The P3BLF and P3BLF+LPS cows had a hoof block, 6 h/d of lying time restricted 2 d/wk, and had their DMI restricted by 30% for 2 d/wk. At weekly intervals during wk 1 to 3 postpartum, P3BLF+LPS cows received jugular administration of 0.031, 0.062, and 0.125 µg of LPS per kg of body weight, respectively. Primary response measurements included hoof lesion and locomotion scoring, lying time, hoof thermography, and weight distribution per hoof. No SU induction occurred but sole hemorrhages, a precursor to SU, occurred during the postchallenge period of all phases. Temperature of the blocked hoof at the end of the challenge period did not change for P3CON cows but increased by 5.5°C and 6.2°C for P3BLF and P3BLF+LPS, respectively. Notable increases in lameness and lack of weight-bearing on the blocked hind hoof occurred for challenge treatment cows during the challenge period of P2 and P3. These changes did not persist after the hoof blocks were removed, indicating that hoof blocks succeeded in altering cow gait mechanics, but not enough to induce long-term lameness or SU. Lying restriction challenged cows in P2 and P3, indicated by a compensatory increase in lying time on the day following lying restriction compared with that on the day before restriction. In P3, lying time had the greatest depression during restriction and compensation following restriction in P3BLF+LPS cows, with LPS challenges potentially increasing the other challenge's effects. Future iterations of the SU induction model should include hoof block use, evaluate longer and more frequent standing and inclusion of forced walking bouts, and include DMI and LPS metabolic challenges." @default.
• W4376133084 created "2023-05-12" @default.
• W4376133084 creator A5007714883 @default.
• W4376133084 creator A5008435958 @default.
• W4376133084 creator A5032493476 @default.
• W4376133084 creator A5040315596 @default.
• W4376133084 creator A5052191187 @default.
• W4376133084 creator A5063252213 @default.
• W4376133084 date "2023-07-01" @default.
• W4376133084 modified "2023-10-09" @default.
• W4376133084 title "An iterative approach to the development of a sole ulcer induction model in Holstein cows" @default.
• W4376133084 cites W1967500510 @default.
• W4376133084 cites W1967522803 @default.
• W4376133084 cites W1969926633 @default.
• W4376133084 cites W1991281399 @default.
• W4376133084 cites W1993322374 @default.
• W4376133084 cites W2000405776 @default.
• W4376133084 cites W2002778382 @default.
• W4376133084 cites W2003980101 @default.
• W4376133084 cites W2005000439 @default.
• W4376133084 cites W2016770117 @default.
• W4376133084 cites W2019329188 @default.
• W4376133084 cites W2030749078 @default.
• W4376133084 cites W2032840351 @default.
• W4376133084 cites W2036048096 @default.
• W4376133084 cites W2036729526 @default.
• W4376133084 cites W2043269339 @default.
• W4376133084 cites W2048235975 @default.
• W4376133084 cites W2056643151 @default.
• W4376133084 cites W2070861247 @default.
• W4376133084 cites W2071474936 @default.
• W4376133084 cites W2074686769 @default.
• W4376133084 cites W2079070751 @default.
• W4376133084 cites W2082301933 @default.
• W4376133084 cites W2084680046 @default.
• W4376133084 cites W2086497865 @default.
• W4376133084 cites W2121001183 @default.
• W4376133084 cites W2128408904 @default.
• W4376133084 cites W2146838893 @default.
• W4376133084 cites W2155480444 @default.
• W4376133084 cites W2156773735 @default.
• W4376133084 cites W2167530525 @default.
• W4376133084 cites W2171603123 @default.
• W4376133084 cites W2172199428 @default.
• W4376133084 cites W2306747019 @default.
• W4376133084 cites W2342869612 @default.
• W4376133084 cites W2343771818 @default.
• W4376133084 cites W2345271095 @default.
• W4376133084 cites W2403460354 @default.
• W4376133084 cites W2604355929 @default.
• W4376133084 cites W2607002304 @default.
• W4376133084 cites W2614274256 @default.
• W4376133084 cites W2620871093 @default.
• W4376133084 cites W2766697893 @default.
• W4376133084 cites W2884066786 @default.
• W4376133084 cites W3005600307 @default.
• W4376133084 cites W3096286459 @default.
• W4376133084 cites W3097130264 @default.
• W4376133084 cites W3164574598 @default.
• W4376133084 cites W3169635211 @default.
• W4376133084 cites W3185910696 @default.
• W4376133084 doi "https://doi.org/10.3168/jds.2022-22726" @default.
• W4376133084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37164859" @default.
• W4376133084 hasPublicationYear "2023" @default.
• W4376133084 type Work @default.
• W4376133084 citedByCount "0" @default.
• W4376133084 crossrefType "journal-article" @default.
• W4376133084 hasAuthorship W4376133084A5007714883 @default.
• W4376133084 hasAuthorship W4376133084A5008435958 @default.
• W4376133084 hasAuthorship W4376133084A5032493476 @default.
• W4376133084 hasAuthorship W4376133084A5040315596 @default.
• W4376133084 hasAuthorship W4376133084A5052191187 @default.
• W4376133084 hasAuthorship W4376133084A5063252213 @default.
• W4376133084 hasBestOaLocation W43761330841 @default.
• W4376133084 hasConcept C105702510 @default.
• W4376133084 hasConcept C140793950 @default.
• W4376133084 hasConcept C141071460 @default.
• W4376133084 hasConcept C22641795 @default.
• W4376133084 hasConcept C2776659692 @default.
• W4376133084 hasConcept C2777652987 @default.
• W4376133084 hasConcept C2779234561 @default.
• W4376133084 hasConcept C2779771469 @default.
• W4376133084 hasConcept C54355233 @default.
• W4376133084 hasConcept C71924100 @default.
• W4376133084 hasConcept C86803240 @default.
• W4376133084 hasConceptScore W4376133084C105702510 @default.
• W4376133084 hasConceptScore W4376133084C140793950 @default.
• W4376133084 hasConceptScore W4376133084C141071460 @default.
• W4376133084 hasConceptScore W4376133084C22641795 @default.
• W4376133084 hasConceptScore W4376133084C2776659692 @default.
• W4376133084 hasConceptScore W4376133084C2777652987 @default.
• W4376133084 hasConceptScore W4376133084C2779234561 @default.
• W4376133084 hasConceptScore W4376133084C2779771469 @default.
• W4376133084 hasConceptScore W4376133084C54355233 @default.
• W4376133084 hasConceptScore W4376133084C71924100 @default.
• W4376133084 hasConceptScore W4376133084C86803240 @default.
• W4376133084 hasIssue "7" @default.
• W4376133084 hasLocation W43761330841 @default.

• next