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- W4376133635 abstract "One of the main concerns of Anfinsen was to reveal the connection between the amino-acid sequence and their biologically active conformation. This search gave rise to two crucial questions in structural biology, namely, why the proteins fold and how a sequence encodes its folding. As to the why, he proposes a plausible answer, namely, the thermodynamic hypothesis. As to the how, this remains an unsolved challenge. Consequently, the protein folding problem is examined here from a new perspective, namely, as an ‘analytic whole’. Conceiving the protein folding in this way enabled us to (i) examine in detail why the force-field-based approaches have failed, among other purposes, in their ability to predict the three-dimensional structure of a protein accurately; (ii) propose how to redefine them to prevent these shortcomings, and (iii) conjecture on the origin of the state-of-the-art numerical-methods success to predict the tridimensional structure of proteins accurately." @default.
- W4376133635 created "2023-05-12" @default.
- W4376133635 creator A5087430326 @default.
- W4376133635 date "2023-04-01" @default.
- W4376133635 modified "2023-10-05" @default.
- W4376133635 title "Rethinking the protein folding problem from a new perspective" @default.
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- W4376133635 doi "https://doi.org/10.1007/s00249-023-01657-w" @default.
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