FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376133651> ?p ?o ?g. }

• W4376133651 abstract "Testosterone may be a possible modifiable risk factor for open-angle glaucoma (OAG) and intraocular pressure (IOP), but evidence has been scarce and conflicting. In this study we evaluated the association of testosterone and its genetic predisposition with incident (i) OAG, IOP, retinal nerve fiber layer (RNFL), and ganglion cell-inner plexiform layer (GCL +).Participants aged 45-100 years were derived from the prospective, population-based Rotterdam Study. Ophthalmic examinations and serum testosterone measurements (including bioavailable and free testosterone) were performed from 1991 onwards. Follow-up took place every 4-5 years. A total of 187 out of 7898 participants were diagnosed with incident (i) OAG during follow-up. Genotyping was performed in 165 glaucoma cases and 6708 controls. We calculated sex-specific weighted genetic risk scores (GRS) for total and bioavailable testosterone. Associations with iOAG were analyzed using multivariable logistic regression. Associations with IOP, RNFL, and GCL + were analyzed with multivariable linear regression. Analyses were stratified on sex and adjusted for at least age, body mass index, and follow-up duration.In men, testosterone was not associated with iOAG. However, the GRS for higher total testosterone was associated with an increased iOAG risk (odds ratio [OR] with 95% confidence interval [95% CI]: 2.48 [1.18; 5.22], per unit). In women, higher values of bioavailable testosterone (2.05 [1.00; 4.18] per nmol/L) and free testosterone (1.79 [1.00; 3.20] per ng/dL) were significantly associated with increased risk of iOAG. Moreover, the GRS for higher bioavailable testosterone was associated with an increased iOAG risk (2.48 [1.09; 5.65], per unit). Higher bioavailable and free testosterone were adversely associated with IOP (0.58 [0.05; 1.10] per nmol/L and 0.47 [0.04; 0.90] per ng/dL). Higher total testosterone was inversely associated with peripapillary RNFL and GCL + (Beta [95% CI]: - 3.54 [- 7.02; - 0.06] per nmol/L and - 2.18 [- 4.11; - 0.25] per nmol/L, respectively).In women, higher testosterone levels increased the risk of iOAG. Both IOP-dependent and IOP-independent mechanisms may underlie this association. Managing testosterone levels may be particularly relevant for the prevention of neurodegeneration in the eye. Future research should confirm these findings." @default.
• W4376133651 created "2023-05-12" @default.
• W4376133651 creator A5012019655 @default.
• W4376133651 creator A5017117138 @default.
• W4376133651 creator A5040960246 @default.
• W4376133651 creator A5041997623 @default.
• W4376133651 creator A5057695261 @default.
• W4376133651 creator A5060719109 @default.
• W4376133651 creator A5066703087 @default.
• W4376133651 date "2023-05-09" @default.
• W4376133651 modified "2023-10-09" @default.
• W4376133651 title "Higher testosterone is associated with open-angle glaucoma in women: a genetic predisposition?" @default.
• W4376133651 cites W1591699638 @default.
• W4376133651 cites W1946539740 @default.
• W4376133651 cites W1997065625 @default.
• W4376133651 cites W1999593787 @default.
• W4376133651 cites W2010328672 @default.
• W4376133651 cites W2012285630 @default.
• W4376133651 cites W2020444788 @default.
• W4376133651 cites W2027907311 @default.
• W4376133651 cites W2034742711 @default.
• W4376133651 cites W2045262611 @default.
• W4376133651 cites W2047278913 @default.
• W4376133651 cites W2047940465 @default.
• W4376133651 cites W2054877457 @default.
• W4376133651 cites W2055947384 @default.
• W4376133651 cites W2057266151 @default.
• W4376133651 cites W2058171880 @default.
• W4376133651 cites W2060809386 @default.
• W4376133651 cites W2063700506 @default.
• W4376133651 cites W2064269302 @default.
• W4376133651 cites W2064516418 @default.
• W4376133651 cites W2069491279 @default.
• W4376133651 cites W2070026825 @default.
• W4376133651 cites W2070842408 @default.
• W4376133651 cites W2077749965 @default.
• W4376133651 cites W2082662520 @default.
• W4376133651 cites W2084608684 @default.
• W4376133651 cites W2098247759 @default.
• W4376133651 cites W2099814945 @default.
• W4376133651 cites W2110617575 @default.
• W4376133651 cites W2114725993 @default.
• W4376133651 cites W2131274956 @default.
• W4376133651 cites W2135301191 @default.
• W4376133651 cites W2142839710 @default.
• W4376133651 cites W2143615665 @default.
• W4376133651 cites W2144155606 @default.
• W4376133651 cites W2157586615 @default.
• W4376133651 cites W2161035234 @default.
• W4376133651 cites W2163210803 @default.
• W4376133651 cites W2169638329 @default.
• W4376133651 cites W2198884807 @default.
• W4376133651 cites W2226440260 @default.
• W4376133651 cites W2295362943 @default.
• W4376133651 cites W2340014298 @default.
• W4376133651 cites W2534158493 @default.
• W4376133651 cites W2604144140 @default.
• W4376133651 cites W2615024914 @default.
• W4376133651 cites W2625091963 @default.
• W4376133651 cites W2731671395 @default.
• W4376133651 cites W2766195635 @default.
• W4376133651 cites W2774033257 @default.
• W4376133651 cites W2803782154 @default.
• W4376133651 cites W2810791529 @default.
• W4376133651 cites W2810823899 @default.
• W4376133651 cites W2883088360 @default.
• W4376133651 cites W2883721162 @default.
• W4376133651 cites W2896401950 @default.
• W4376133651 cites W2900542798 @default.
• W4376133651 cites W2900801340 @default.
• W4376133651 cites W2940625196 @default.
• W4376133651 cites W2942559041 @default.
• W4376133651 cites W3004892753 @default.
• W4376133651 cites W3016822999 @default.
• W4376133651 cites W3023972366 @default.
• W4376133651 cites W3025039486 @default.
• W4376133651 cites W3037221203 @default.
• W4376133651 cites W3087471474 @default.
• W4376133651 cites W3092152621 @default.
• W4376133651 cites W3134892789 @default.
• W4376133651 cites W3169428046 @default.
• W4376133651 cites W3178548369 @default.
• W4376133651 cites W4206944193 @default.
• W4376133651 cites W4220980163 @default.
• W4376133651 cites W4280603565 @default.
• W4376133651 cites W4282044685 @default.
• W4376133651 cites W4295990640 @default.
• W4376133651 cites W46828449 @default.
• W4376133651 doi "https://doi.org/10.1186/s13293-023-00512-z" @default.
• W4376133651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37161452" @default.
• W4376133651 hasPublicationYear "2023" @default.
• W4376133651 type Work @default.
• W4376133651 citedByCount "0" @default.
• W4376133651 crossrefType "journal-article" @default.
• W4376133651 hasAuthorship W4376133651A5012019655 @default.
• W4376133651 hasAuthorship W4376133651A5017117138 @default.
• W4376133651 hasAuthorship W4376133651A5040960246 @default.
• W4376133651 hasAuthorship W4376133651A5041997623 @default.
• W4376133651 hasAuthorship W4376133651A5057695261 @default.
• W4376133651 hasAuthorship W4376133651A5060719109 @default.

• next