FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376135630> ?p ?o ?g. }

• W4376135630 abstract "Abstract Background Intrinsic subtypes have played an important role in breast cancer research. The accuracy of breast cancer research findings depends on the accuracy of intrinsic subtype classification of breast cancer samples. Popular intrinsic subtype models, such as PAM50 and AIMS, were mainly developed on Microarray but are widely used in other platforms. The transferability of these models to RNA-seq and other platforms has rarely been studied. We aim to assess the effectiveness of popular intrinsic subtype models on RNA-seq data and improve the accuracy of breast cancer subtyping on this platform. Methods Assuming that one breast cancer sample only belongs to one subtype irrespective of the expression measuring platform, we assessed the consistency of subtype predictions of PAM50 and AIMS for TCGA Microarray and RNA-seq data from the same samples using Kappa statistic. We also built 12 models using common and intrinsic genes on both Microarray and RNA-seq data, and evaluated their performance under the same assumption. Results Both PAM50 and AIMS failed to produce consistent predictions for Microarray and RNA-seq data from the same samples, with Kappa values of 0.33 and 0.21, respectively. Data normalization improved prediction consistency but introduced false classification. Microarray-developed models showed low prediction consistency when applied to both Microarray and RNA-seq profiles of the same samples. However, prediction consistency between predictions of RNA-seq developed model predicting RNA-seq data and Microarray developed model predicting Microarray data was high with most Kappa values above 0.85. Conclusion Great caution should be taken when using PAM50 and AIMS for the subtyping of breast cancer RNA-seq data. Breast cancer subtyping models should be developed and applied on the same platform, using unnormalized expression data for accurate subtype prediction purpose." @default.
• W4376135630 created "2023-05-12" @default.
• W4376135630 creator A5050475671 @default.
• W4376135630 creator A5082286909 @default.
• W4376135630 date "2023-05-11" @default.
• W4376135630 modified "2023-10-17" @default.
• W4376135630 title "The Importance of Development and Application of Subtyping Models for Breast Cancer on the Same Platform" @default.
• W4376135630 cites W1831050183 @default.
• W4376135630 cites W2035793132 @default.
• W4376135630 cites W2053154970 @default.
• W4376135630 cites W2064397275 @default.
• W4376135630 cites W2067664604 @default.
• W4376135630 cites W2096192437 @default.
• W4376135630 cites W2096283457 @default.
• W4376135630 cites W2097255042 @default.
• W4376135630 cites W2101851382 @default.
• W4376135630 cites W2105776281 @default.
• W4376135630 cites W2106833357 @default.
• W4376135630 cites W2114754216 @default.
• W4376135630 cites W2131994307 @default.
• W4376135630 cites W2132619562 @default.
• W4376135630 cites W2132750127 @default.
• W4376135630 cites W2138550913 @default.
• W4376135630 cites W2145552137 @default.
• W4376135630 cites W2157168213 @default.
• W4376135630 cites W2157840751 @default.
• W4376135630 cites W2160938378 @default.
• W4376135630 cites W2164777277 @default.
• W4376135630 cites W2172358623 @default.
• W4376135630 cites W2230320310 @default.
• W4376135630 cites W2414214572 @default.
• W4376135630 cites W2589558051 @default.
• W4376135630 cites W2909301717 @default.
• W4376135630 cites W2917464640 @default.
• W4376135630 cites W2949017090 @default.
• W4376135630 cites W2980183989 @default.
• W4376135630 cites W3028523516 @default.
• W4376135630 cites W3080717832 @default.
• W4376135630 cites W3109908270 @default.
• W4376135630 cites W4226295940 @default.
• W4376135630 cites W4291972535 @default.
• W4376135630 cites W4315647082 @default.
• W4376135630 cites W4317881492 @default.
• W4376135630 cites W4318220594 @default.
• W4376135630 cites W4318706061 @default.
• W4376135630 doi "https://doi.org/10.21203/rs.3.rs-2908014/v1" @default.
• W4376135630 hasPublicationYear "2023" @default.
• W4376135630 type Work @default.
• W4376135630 citedByCount "0" @default.
• W4376135630 crossrefType "posted-content" @default.
• W4376135630 hasAuthorship W4376135630A5050475671 @default.
• W4376135630 hasAuthorship W4376135630A5082286909 @default.
• W4376135630 hasBestOaLocation W43761356301 @default.
• W4376135630 hasConcept C104317684 @default.
• W4376135630 hasConcept C119857082 @default.
• W4376135630 hasConcept C121608353 @default.
• W4376135630 hasConcept C124101348 @default.
• W4376135630 hasConcept C126322002 @default.
• W4376135630 hasConcept C140331021 @default.
• W4376135630 hasConcept C150194340 @default.
• W4376135630 hasConcept C154945302 @default.
• W4376135630 hasConcept C186836561 @default.
• W4376135630 hasConcept C199360897 @default.
• W4376135630 hasConcept C2524010 @default.
• W4376135630 hasConcept C2776436953 @default.
• W4376135630 hasConcept C2778724333 @default.
• W4376135630 hasConcept C33923547 @default.
• W4376135630 hasConcept C41008148 @default.
• W4376135630 hasConcept C530470458 @default.
• W4376135630 hasConcept C54355233 @default.
• W4376135630 hasConcept C60644358 @default.
• W4376135630 hasConcept C61272859 @default.
• W4376135630 hasConcept C70721500 @default.
• W4376135630 hasConcept C71924100 @default.
• W4376135630 hasConcept C83852419 @default.
• W4376135630 hasConcept C8415881 @default.
• W4376135630 hasConcept C86803240 @default.
• W4376135630 hasConceptScore W4376135630C104317684 @default.
• W4376135630 hasConceptScore W4376135630C119857082 @default.
• W4376135630 hasConceptScore W4376135630C121608353 @default.
• W4376135630 hasConceptScore W4376135630C124101348 @default.
• W4376135630 hasConceptScore W4376135630C126322002 @default.
• W4376135630 hasConceptScore W4376135630C140331021 @default.
• W4376135630 hasConceptScore W4376135630C150194340 @default.
• W4376135630 hasConceptScore W4376135630C154945302 @default.
• W4376135630 hasConceptScore W4376135630C186836561 @default.
• W4376135630 hasConceptScore W4376135630C199360897 @default.
• W4376135630 hasConceptScore W4376135630C2524010 @default.
• W4376135630 hasConceptScore W4376135630C2776436953 @default.
• W4376135630 hasConceptScore W4376135630C2778724333 @default.
• W4376135630 hasConceptScore W4376135630C33923547 @default.
• W4376135630 hasConceptScore W4376135630C41008148 @default.
• W4376135630 hasConceptScore W4376135630C530470458 @default.
• W4376135630 hasConceptScore W4376135630C54355233 @default.
• W4376135630 hasConceptScore W4376135630C60644358 @default.
• W4376135630 hasConceptScore W4376135630C61272859 @default.
• W4376135630 hasConceptScore W4376135630C70721500 @default.
• W4376135630 hasConceptScore W4376135630C71924100 @default.
• W4376135630 hasConceptScore W4376135630C83852419 @default.
• W4376135630 hasConceptScore W4376135630C8415881 @default.

• next