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- W4376137845 abstract "Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased proteomic profiling of synapses purified from the dorsolateral prefrontal cortex of 35 cases of SCZ, 35 cases of BP, and 35 controls. Compared with controls, SCZ and BP synapses show substantial and similar proteomic alterations. Network analyses reveal upregulation of proteins associated with autophagy and certain vesicle transport pathways and downregulation of proteins related to synaptic, mitochondrial, and ribosomal function in the synapses of individuals with SCZ or BP. Some of the same pathways are similarly dysregulated in the synaptic proteome of mutant mice deficient in Akap11, a recently discovered shared risk gene for SCZ and BP. Our work provides biological insights into molecular dysfunction at the synapse in SCZ and BP and serves as a resource for understanding the pathophysiology of these disorders." @default.
- W4376137845 created "2023-05-12" @default.
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- W4376137845 date "2023-05-01" @default.
- W4376137845 modified "2023-10-03" @default.
- W4376137845 title "Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model" @default.
- W4376137845 cites W1502421007 @default.
- W4376137845 cites W1602103399 @default.
- W4376137845 cites W1789266792 @default.
- W4376137845 cites W1966327575 @default.
- W4376137845 cites W1967232661 @default.
- W4376137845 cites W1971347175 @default.
- W4376137845 cites W2001467419 @default.
- W4376137845 cites W2007861303 @default.
- W4376137845 cites W2010457001 @default.
- W4376137845 cites W2012356934 @default.
- W4376137845 cites W2019465651 @default.
- W4376137845 cites W2019761487 @default.
- W4376137845 cites W2023962370 @default.
- W4376137845 cites W2032711010 @default.
- W4376137845 cites W2044336832 @default.
- W4376137845 cites W2045085957 @default.
- W4376137845 cites W2055406931 @default.
- W4376137845 cites W2071318481 @default.
- W4376137845 cites W2072621593 @default.
- W4376137845 cites W2082868411 @default.
- W4376137845 cites W2094205174 @default.
- W4376137845 cites W2095639924 @default.
- W4376137845 cites W2097424141 @default.
- W4376137845 cites W2101357408 @default.
- W4376137845 cites W2105527159 @default.
- W4376137845 cites W2127683408 @default.
- W4376137845 cites W2131271579 @default.
- W4376137845 cites W2134282732 @default.
- W4376137845 cites W2138207763 @default.
- W4376137845 cites W2141672742 @default.
- W4376137845 cites W2146512944 @default.
- W4376137845 cites W2166443964 @default.
- W4376137845 cites W2169456326 @default.
- W4376137845 cites W2170752133 @default.
- W4376137845 cites W2179438025 @default.
- W4376137845 cites W2255138985 @default.
- W4376137845 cites W2266075323 @default.
- W4376137845 cites W2557456660 @default.
- W4376137845 cites W2560304089 @default.
- W4376137845 cites W2606988847 @default.
- W4376137845 cites W2745116209 @default.
- W4376137845 cites W2797625475 @default.
- W4376137845 cites W2802593879 @default.
- W4376137845 cites W2803472374 @default.
- W4376137845 cites W2883175830 @default.
- W4376137845 cites W2885443815 @default.
- W4376137845 cites W2885491854 @default.
- W4376137845 cites W2898757824 @default.
- W4376137845 cites W2907315139 @default.
- W4376137845 cites W2913059934 @default.
- W4376137845 cites W2948150815 @default.
- W4376137845 cites W2948949781 @default.
- W4376137845 cites W2950375827 @default.
- W4376137845 cites W2951325776 @default.
- W4376137845 cites W2952034853 @default.
- W4376137845 cites W2953330634 @default.
- W4376137845 cites W2982258035 @default.
- W4376137845 cites W2983765585 @default.
- W4376137845 cites W2995971356 @default.
- W4376137845 cites W2999279779 @default.
- W4376137845 cites W3004013987 @default.
- W4376137845 cites W3015522591 @default.
- W4376137845 cites W3046000932 @default.
- W4376137845 cites W3112376646 @default.
- W4376137845 cites W3114419121 @default.
- W4376137845 cites W3136511412 @default.
- W4376137845 cites W3157396950 @default.
- W4376137845 cites W3159650156 @default.
- W4376137845 cites W3161760991 @default.
- W4376137845 cites W3162259891 @default.
- W4376137845 cites W3165410637 @default.
- W4376137845 cites W3175961346 @default.
- W4376137845 cites W3182953012 @default.
- W4376137845 cites W3199291386 @default.
- W4376137845 cites W3200263151 @default.
- W4376137845 cites W3217194727 @default.
- W4376137845 cites W4210681189 @default.
- W4376137845 cites W4211013640 @default.
- W4376137845 cites W4211025465 @default.
- W4376137845 cites W4220991498 @default.
- W4376137845 cites W4223433728 @default.
- W4376137845 cites W4223520055 @default.
- W4376137845 cites W4223536896 @default.
- W4376137845 cites W4296777506 @default.
- W4376137845 cites W4324130073 @default.