Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376150012> ?p ?o ?g. }
- W4376150012 abstract "Abstract Background Macrophage is a critical regulator in wound healing and scar formation, and SIRT1 is related to macrophage activation and polarization, while the specific mechanism is still unclear. Methods To explore the specific effects of SIRT1 in scarring, we established skin incision mice model and LPS induced inflammation cell model. The expression of SIRT1 in tissue and macrophage was detected, and level of SIRT1 was changed to observe the downstream effects. LPS-induced macrophages with or without SIRT1 deficiency were used for TMT-based quantitative proteomic analysis. Results SIRT1 was suppressed in scar while increased in macrophages of scar tissue. And macrophages were proven to be necessary for wound healing. In the early stage of wound healing, knockout of SIRT1 in macrophage could greatly strengthen inflammation and finally promote scarring. NADH-related activities and oxidoreductase activities were differentially expressed in TMT-based quantitative proteomic analysis. We confirmed that ROS production and NOX2 level were elevated after LPS stimulation while the Nrf2 pathway and the downstream proteins, such as Nqo-1 and HO-1, were suppressed. In contrast, the suppression of SIRT1 strengthened this trend. The NF-κB pathway was remarkably activated compared with the control group. Conclusions Insufficient increase of SIRT1 in macrophage leads to over activated oxidative stress and activates NF-κB pathways, which then promotes inflammation in wound healing and scarring. Further increasing SIRT1 in macrophages could be a promising method to alleviate scarring." @default.
- W4376150012 created "2023-05-12" @default.
- W4376150012 creator A5001227027 @default.
- W4376150012 creator A5002557721 @default.
- W4376150012 creator A5018699150 @default.
- W4376150012 creator A5030193203 @default.
- W4376150012 creator A5046624620 @default.
- W4376150012 creator A5078506074 @default.
- W4376150012 creator A5079520012 @default.
- W4376150012 creator A5079811578 @default.
- W4376150012 date "2023-05-11" @default.
- W4376150012 modified "2023-10-16" @default.
- W4376150012 title "Insufficient SIRT1 in macrophages promotes oxidative stress and inflammation during scarring" @default.
- W4376150012 cites W1979504051 @default.
- W4376150012 cites W2118654016 @default.
- W4376150012 cites W2278090462 @default.
- W4376150012 cites W2556776430 @default.
- W4376150012 cites W2599822883 @default.
- W4376150012 cites W2621934018 @default.
- W4376150012 cites W2640452423 @default.
- W4376150012 cites W2735726751 @default.
- W4376150012 cites W2756243705 @default.
- W4376150012 cites W2769071992 @default.
- W4376150012 cites W2781586813 @default.
- W4376150012 cites W2782685575 @default.
- W4376150012 cites W2789248221 @default.
- W4376150012 cites W2808963397 @default.
- W4376150012 cites W2888455562 @default.
- W4376150012 cites W2913105578 @default.
- W4376150012 cites W2914333610 @default.
- W4376150012 cites W2950668575 @default.
- W4376150012 cites W2963431472 @default.
- W4376150012 cites W3000104452 @default.
- W4376150012 cites W3003871182 @default.
- W4376150012 cites W3004393739 @default.
- W4376150012 cites W3006891752 @default.
- W4376150012 cites W3020196078 @default.
- W4376150012 cites W3025324697 @default.
- W4376150012 cites W3035862891 @default.
- W4376150012 cites W3036502700 @default.
- W4376150012 cites W3087497174 @default.
- W4376150012 cites W3115587212 @default.
- W4376150012 cites W3121495659 @default.
- W4376150012 cites W3193357110 @default.
- W4376150012 cites W3195196860 @default.
- W4376150012 cites W3198716004 @default.
- W4376150012 cites W4220897376 @default.
- W4376150012 doi "https://doi.org/10.21203/rs.3.rs-2600797/v1" @default.
- W4376150012 hasPublicationYear "2023" @default.
- W4376150012 type Work @default.
- W4376150012 citedByCount "0" @default.
- W4376150012 crossrefType "posted-content" @default.
- W4376150012 hasAuthorship W4376150012A5001227027 @default.
- W4376150012 hasAuthorship W4376150012A5002557721 @default.
- W4376150012 hasAuthorship W4376150012A5018699150 @default.
- W4376150012 hasAuthorship W4376150012A5030193203 @default.
- W4376150012 hasAuthorship W4376150012A5046624620 @default.
- W4376150012 hasAuthorship W4376150012A5078506074 @default.
- W4376150012 hasAuthorship W4376150012A5079520012 @default.
- W4376150012 hasAuthorship W4376150012A5079811578 @default.
- W4376150012 hasBestOaLocation W43761500121 @default.
- W4376150012 hasConcept C104317684 @default.
- W4376150012 hasConcept C127561419 @default.
- W4376150012 hasConcept C170493617 @default.
- W4376150012 hasConcept C182704531 @default.
- W4376150012 hasConcept C185592680 @default.
- W4376150012 hasConcept C202751555 @default.
- W4376150012 hasConcept C203014093 @default.
- W4376150012 hasConcept C2776151105 @default.
- W4376150012 hasConcept C2776682551 @default.
- W4376150012 hasConcept C2776914184 @default.
- W4376150012 hasConcept C2779244956 @default.
- W4376150012 hasConcept C2780269544 @default.
- W4376150012 hasConcept C502942594 @default.
- W4376150012 hasConcept C55493867 @default.
- W4376150012 hasConcept C6929976 @default.
- W4376150012 hasConcept C71924100 @default.
- W4376150012 hasConcept C86803240 @default.
- W4376150012 hasConcept C95444343 @default.
- W4376150012 hasConceptScore W4376150012C104317684 @default.
- W4376150012 hasConceptScore W4376150012C127561419 @default.
- W4376150012 hasConceptScore W4376150012C170493617 @default.
- W4376150012 hasConceptScore W4376150012C182704531 @default.
- W4376150012 hasConceptScore W4376150012C185592680 @default.
- W4376150012 hasConceptScore W4376150012C202751555 @default.
- W4376150012 hasConceptScore W4376150012C203014093 @default.
- W4376150012 hasConceptScore W4376150012C2776151105 @default.
- W4376150012 hasConceptScore W4376150012C2776682551 @default.
- W4376150012 hasConceptScore W4376150012C2776914184 @default.
- W4376150012 hasConceptScore W4376150012C2779244956 @default.
- W4376150012 hasConceptScore W4376150012C2780269544 @default.
- W4376150012 hasConceptScore W4376150012C502942594 @default.
- W4376150012 hasConceptScore W4376150012C55493867 @default.
- W4376150012 hasConceptScore W4376150012C6929976 @default.
- W4376150012 hasConceptScore W4376150012C71924100 @default.
- W4376150012 hasConceptScore W4376150012C86803240 @default.
- W4376150012 hasConceptScore W4376150012C95444343 @default.
- W4376150012 hasLocation W43761500121 @default.
- W4376150012 hasOpenAccess W4376150012 @default.
- W4376150012 hasPrimaryLocation W43761500121 @default.