Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376150135> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4376150135 endingPage "227" @default.
- W4376150135 startingPage "226" @default.
- W4376150135 abstract "The mechanisms underlying the increase in the frequency of heartbeat induced by catecholamines, so called fight-or-flight response (FFR) of heart rate (HR), are incompletely understood. cAMP-dependent regulation of f-(HCN) channels, underlying the “funny” current (If), and ryanodine receptor 2 (RyR2)-mediated Ca2+ release are considered as the predominant mechanisms of HR FFR. However, it is showed that If contributes to setting the basal HR, but is not required for the sympathetic regulation of pacemaking. In addition, impairment of RyR2-mediated [Ca2+]i release by ryanodine only reduces β-adrenergic regulation of pacemaker activity, suggesting that other mechanism(s) are involved in the generation of HR FFR. We have shown that L-type Cav1.3 calcium channels are required for β-adrenergic mediated initiation of firing in dormant sino-atrial node (SAN) pacemaker cells. To define the role of Cav1.3 channels in the FFR of HR and SAN automaticity. We crossed mice deficient in Cav1.3 channels (Cav1.3-/-) with mice (CNBD) lacking cAMP sensitivity of f-channels. In vivo and in isolated hearts ECG recordings were performed. Automaticity and diastolic current of SAN cells were evaluated using patch-clamp technique. Cav1.3-/- and CNBD mice displayed bradycardia at rest, but similar degree of increase in HR after β-adrenergic stimulation by injection of isoproterenol (ISO) in comparison to WT mice. However, Cav1.3-/-/CNBD mice did not show significant HR increase in vivo after injection of ISO or during physical exercise. ISO failed to increase the rate in isolated herats and in the SAN cells from Cav1.3-/-/CNBD mice. Consistent with these data, mutant mice in which L-type Cav1.2 channels have been rendered insensitive to dihydropyridines (Cav1.2DHP-/-) showed that concomitant selective pharmacologic inhibition of Cav1.3 and cAMP-dependent dependent regulation of f-HCN channels by the di-cyclic nucleotide di-cGMP prevented the positive chronotropic response to ISO of SAN cells automaticity. Under the same conditions, ISO did not significantly increase diastolic current, explaining loss of SAN FFR. Our study identifies L-type Cav1.3 channels as key effectors of β-adrenergic regulation of SAN automaticity with If." @default.
- W4376150135 created "2023-05-12" @default.
- W4376150135 creator A5001992591 @default.
- W4376150135 creator A5002908284 @default.
- W4376150135 creator A5013301495 @default.
- W4376150135 creator A5041986611 @default.
- W4376150135 creator A5046758720 @default.
- W4376150135 creator A5053102650 @default.
- W4376150135 creator A5054449033 @default.
- W4376150135 creator A5058892193 @default.
- W4376150135 creator A5078582712 @default.
- W4376150135 creator A5084054607 @default.
- W4376150135 date "2023-05-01" @default.
- W4376150135 modified "2023-09-26" @default.
- W4376150135 title "Control of the fight-or-flight response of heart rate by L-type Cav1.3 (α1D) calcium channels" @default.
- W4376150135 doi "https://doi.org/10.1016/j.acvdsp.2023.03.107" @default.
- W4376150135 hasPublicationYear "2023" @default.
- W4376150135 type Work @default.
- W4376150135 citedByCount "0" @default.
- W4376150135 crossrefType "journal-article" @default.
- W4376150135 hasAuthorship W4376150135A5001992591 @default.
- W4376150135 hasAuthorship W4376150135A5002908284 @default.
- W4376150135 hasAuthorship W4376150135A5013301495 @default.
- W4376150135 hasAuthorship W4376150135A5041986611 @default.
- W4376150135 hasAuthorship W4376150135A5046758720 @default.
- W4376150135 hasAuthorship W4376150135A5053102650 @default.
- W4376150135 hasAuthorship W4376150135A5054449033 @default.
- W4376150135 hasAuthorship W4376150135A5058892193 @default.
- W4376150135 hasAuthorship W4376150135A5078582712 @default.
- W4376150135 hasAuthorship W4376150135A5084054607 @default.
- W4376150135 hasConcept C113217602 @default.
- W4376150135 hasConcept C126322002 @default.
- W4376150135 hasConcept C134018914 @default.
- W4376150135 hasConcept C13852961 @default.
- W4376150135 hasConcept C164705383 @default.
- W4376150135 hasConcept C18699975 @default.
- W4376150135 hasConcept C24998067 @default.
- W4376150135 hasConcept C2776972302 @default.
- W4376150135 hasConcept C2777495988 @default.
- W4376150135 hasConcept C2777953023 @default.
- W4376150135 hasConcept C2778542873 @default.
- W4376150135 hasConcept C38652104 @default.
- W4376150135 hasConcept C41008148 @default.
- W4376150135 hasConcept C519063684 @default.
- W4376150135 hasConcept C71924100 @default.
- W4376150135 hasConcept C84393581 @default.
- W4376150135 hasConceptScore W4376150135C113217602 @default.
- W4376150135 hasConceptScore W4376150135C126322002 @default.
- W4376150135 hasConceptScore W4376150135C134018914 @default.
- W4376150135 hasConceptScore W4376150135C13852961 @default.
- W4376150135 hasConceptScore W4376150135C164705383 @default.
- W4376150135 hasConceptScore W4376150135C18699975 @default.
- W4376150135 hasConceptScore W4376150135C24998067 @default.
- W4376150135 hasConceptScore W4376150135C2776972302 @default.
- W4376150135 hasConceptScore W4376150135C2777495988 @default.
- W4376150135 hasConceptScore W4376150135C2777953023 @default.
- W4376150135 hasConceptScore W4376150135C2778542873 @default.
- W4376150135 hasConceptScore W4376150135C38652104 @default.
- W4376150135 hasConceptScore W4376150135C41008148 @default.
- W4376150135 hasConceptScore W4376150135C519063684 @default.
- W4376150135 hasConceptScore W4376150135C71924100 @default.
- W4376150135 hasConceptScore W4376150135C84393581 @default.
- W4376150135 hasIssue "2" @default.
- W4376150135 hasLocation W43761501351 @default.
- W4376150135 hasOpenAccess W4376150135 @default.
- W4376150135 hasPrimaryLocation W43761501351 @default.
- W4376150135 hasRelatedWork W2034768996 @default.
- W4376150135 hasRelatedWork W2054992011 @default.
- W4376150135 hasRelatedWork W2064416809 @default.
- W4376150135 hasRelatedWork W2091541681 @default.
- W4376150135 hasRelatedWork W2120961111 @default.
- W4376150135 hasRelatedWork W2260208019 @default.
- W4376150135 hasRelatedWork W2883421968 @default.
- W4376150135 hasRelatedWork W3109414016 @default.
- W4376150135 hasRelatedWork W3190907651 @default.
- W4376150135 hasRelatedWork W4376150135 @default.
- W4376150135 hasVolume "15" @default.
- W4376150135 isParatext "false" @default.
- W4376150135 isRetracted "false" @default.
- W4376150135 workType "article" @default.