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• W4376150147 abstract "Diastolic dysfunction after STEMI is under documented despite its impact on cardiovascular events. We focused on inflammatory biomarkers within hours after STEMI and their association with diastolic dysfunction at one month post-STEMI. Our aim was to identify an inflammatory profile promoting diastolic dysfunction in STEMI patients. We prospectively included STEMI patients admitted in our hospital from 2016 to 2019. We collected sera at 5 time points [admission (H0), 4 hours (H4), H24, H48 an 1 month]. Inflammatory biomarkers serum levels were assessed using ELISA assays (cytokines, chemokines and endothelial activation biomarkers). Transthoracic echocardiogram and cardiac MRI to assess diastolic function and infarct size were carried out at one month post-STEMI. We used last guidelines from the EACVI to grade diastolic function. Patients were followed for 12 months. Complete echocardiographic data were available for 236 patients. There were 163 patients with normal diastolic function and 73 patients with diastolic dysfunction. As expected, patients with diastolic dysfunction had higher BNP level (197.0 ng/L versus 68 ng/L, P < 0.001) and were more likely to have a MACE during the first 12 months after STEMI compared to patients normal diastolic function (HR = 3.0, CI [1.1–7.9], P = 0.01). Patients with diastolic dysfunction at one month had higher inflammatory biomarkers within the first 48 h post-STEMI compared with patient with normal diastolic function (Fig. 1): CRP AUC (660.2 mg.h.L−1 vs. 361.4 mg.h.L−1 P = 0.02), IL-6 AUC (206.0 pg.h.mL−1 vs. 173.1 pg.h.mL−1 P = 0.03) sTNFR1 AUC (27.6 ng.h.mL−1 versus 24.1 ng.h.mL−1, P = 0.03), sTNFR2 AUC (44.7 ng.h.mL−1 vs. 43.5 ng.h.mL−1, P = 0.03) sST2 AUC (30.4 pg.h.mL−1 vs. 27.3 pg.h.mL−1, P = 0.046), GDF15 AUC (10.8 ng.h.mL−1 vs. 8.1 ng.h.mL−1, P = 0.050) and IL-10 AUC (174.6 pg.h.mL−1 vs. 122.8 pg.h.mL−1, P = 0.02). There was no significant difference in infarct size (13 versus 17% of left ventricular mass, P = 0.06) or LVEF (58 versus 54%, P = 0.0523) between the two groups. Diastolic function seems influenced by the early post-STEMI inflammatory environment. These results should be considered in future mechanistical study and in patients’ care." @default.
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• W4376150147 date "2023-05-01" @default.
• W4376150147 modified "2023-10-18" @default.
• W4376150147 title "Post-infarction inflammation influences diastolic function after STEMI" @default.
• W4376150147 doi "https://doi.org/10.1016/j.acvdsp.2023.03.045" @default.
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