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- W4376171681 endingPage "e0285086" @default.
- W4376171681 startingPage "e0285086" @default.
- W4376171681 abstract "Objectives Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and by compromised interhemispheric connectivity. Methods We studied these issues in 52 ADHD and 43 non-clinical adults by comparing: (1) stop-signal reaction time (SSRT); (2) frontal asymmetry of the N200 event-related potential component, which is evoked during response inhibition and is lateralised to the right hemisphere; (3) TMS-evoked potential (TEP) in the right frontal hemisphere, which is indicative of local cortical excitability; and (4) frontal right-to-left interhemispheric TMS signal propagation (ISP), which is reversely indicative of interhemispheric connectivity. Results Compared to controls, the ADHD group demonstrated elongated SSRT, reduced N200 right-frontal-asymmetry, weaker TEP, and stronger ISP. Moreover, in the ADHD group, N200 right-frontal-asymmetry correlated with SSRT, with TEP, and with symptoms severity. Conversely, no relationship was observed between ISP and N200 right-frontal-asymmetry, and both TEP and ISP were found to be unrelated to SSRT. Conclusions Our results indicate that abnormal frontal asymmetry is related to a key cognitive symptom in ADHD and suggest that it is underlined by reduced right-frontal excitability." @default.
- W4376171681 created "2023-05-12" @default.
- W4376171681 creator A5017493910 @default.
- W4376171681 creator A5041440361 @default.
- W4376171681 creator A5043230342 @default.
- W4376171681 creator A5059547432 @default.
- W4376171681 date "2023-05-25" @default.
- W4376171681 modified "2023-09-27" @default.
- W4376171681 title "Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study" @default.
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