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- W4376223586 abstract "Abstract Ras GTPases, well characterized for their role in oncogenesis, are the cells’ molecular switches that signal to maintain immune homeostasis through cellular development, proliferation, differentiation, survival, and apoptosis. In the immune system, T cells are the central players that cause autoimmunity if dysregulated. Antigen‐specific T‐cell receptor (TCR) stimulation activates Ras‐isoforms, which exhibit isoform‐specific activator and effector requirements, functional specificities, and a selective role in T‐cell development and differentiation. Recent studies show the role of Ras in T‐cell‐mediated autoimmune diseases; however, there is a scarcity of knowledge about the role of Ras in T‐cell development and differentiation. To date, limited studies have demonstrated Ras activation in response to positive and negative selection signals and Ras isoform‐specific signaling, including subcellular signaling, in immune cells. The knowledge of isoform‐specific functions of Ras in T cells is essential, but still inadequate to develop the T‐cell‐targeted Ras isoform‐specific treatment strategies for the diseases caused by altered Ras‐isoform expression and activation in T cells. In this review, we discuss the role of Ras in T‐cell development and differentiation, critically analyzing the isoform‐specific functions." @default.
- W4376223586 created "2023-05-13" @default.
- W4376223586 creator A5017451807 @default.
- W4376223586 creator A5024742527 @default.
- W4376223586 creator A5041660822 @default.
- W4376223586 date "2023-05-28" @default.
- W4376223586 modified "2023-10-17" @default.
- W4376223586 title "Isoform‐specific functions of Ras in T‐cell development and differentiation" @default.
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- W4376223586 doi "https://doi.org/10.1002/eji.202350430" @default.
- W4376223586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37173132" @default.
- W4376223586 hasPublicationYear "2023" @default.
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