Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376223870> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4376223870 abstract "Abstract Purpose To compare toxicity of radiotherapy (RT) with concomitant chemotherapy (CHT) in patients (pts) with anal cancer treated with simultaneous integrated boost (SIB) versus sequential boost (SeqB). Methods Sixty-six patients were treated from 2007 to 2021. Thirty patients underwent to SeqB concurrent to CHT and 37 to SIB-group. Toxicity assessment has been considered in acute and in late toxicities for gastrointestinal (GI), genitourinary (GU), cutaneous (CU) districts, according to Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0. The Wexner scale among summary scoring systems has been used as a tool to measure fecal incontinence. The chi-square test for ordinal variables were used to evaluate the association between patient and treatment characteristics and acute or late severe toxicity. Univariable logistic regression models were fit to evaluate predictive factors associated with fecal incontinence. Results Median follow-up was 61.5 months (IQR, 27.1–121.7 months) for all patients. Severe acute toxicity (≥ G2) was observed in 49 patients (74.2%). Late toxicity (≥ G2) occurred in 13 cases (19.6%). In assessment of cutaneous toxicity, there was also a significant reduction in ≥ G1 in SIB group with 29 patients (80.5%) vs SeqB group with 29 patients (96.6%) (p-value = 0.046). Of both groups 11 patients (16.6%) developed fecal incontinence, 8 (22%) in the SIB group and 3 (10%) in the SeqB. Conclusion SIB for anal cancer treatment results in reduced acute and late cutaneous toxicity compared to SeqB. According to our results the rate of other acute and late toxicities are low and comparable between the two groups." @default.
- W4376223870 created "2023-05-13" @default.
- W4376223870 creator A5003630947 @default.
- W4376223870 creator A5009174144 @default.
- W4376223870 creator A5015330209 @default.
- W4376223870 creator A5019881360 @default.
- W4376223870 creator A5043003981 @default.
- W4376223870 creator A5069369968 @default.
- W4376223870 creator A5080822461 @default.
- W4376223870 date "2023-05-12" @default.
- W4376223870 modified "2023-09-25" @default.
- W4376223870 title "Comparative analysis of toxicity in patients with anal cancer undergoing definitive simultaneous integrated boost (SIB) or sequential integrated boost (SeqB) radiotherapy" @default.
- W4376223870 cites W1804130247 @default.
- W4376223870 cites W1867572965 @default.
- W4376223870 cites W1971049995 @default.
- W4376223870 cites W1975346795 @default.
- W4376223870 cites W2001193723 @default.
- W4376223870 cites W2004367809 @default.
- W4376223870 cites W2008750108 @default.
- W4376223870 cites W2026658505 @default.
- W4376223870 cites W2038954388 @default.
- W4376223870 cites W2045804591 @default.
- W4376223870 cites W2065565788 @default.
- W4376223870 cites W2076341925 @default.
- W4376223870 cites W2113393023 @default.
- W4376223870 cites W2117300470 @default.
- W4376223870 cites W2126246492 @default.
- W4376223870 cites W2158244375 @default.
- W4376223870 cites W2161345714 @default.
- W4376223870 cites W2164644812 @default.
- W4376223870 cites W2891327271 @default.
- W4376223870 cites W2892675161 @default.
- W4376223870 cites W2993058512 @default.
- W4376223870 cites W3004950999 @default.
- W4376223870 cites W3083679990 @default.
- W4376223870 doi "https://doi.org/10.1007/s00384-023-04411-y" @default.
- W4376223870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37171509" @default.
- W4376223870 hasPublicationYear "2023" @default.
- W4376223870 type Work @default.
- W4376223870 citedByCount "0" @default.
- W4376223870 crossrefType "journal-article" @default.
- W4376223870 hasAuthorship W4376223870A5003630947 @default.
- W4376223870 hasAuthorship W4376223870A5009174144 @default.
- W4376223870 hasAuthorship W4376223870A5015330209 @default.
- W4376223870 hasAuthorship W4376223870A5019881360 @default.
- W4376223870 hasAuthorship W4376223870A5043003981 @default.
- W4376223870 hasAuthorship W4376223870A5069369968 @default.
- W4376223870 hasAuthorship W4376223870A5080822461 @default.
- W4376223870 hasBestOaLocation W43762238701 @default.
- W4376223870 hasConcept C116263406 @default.
- W4376223870 hasConcept C121608353 @default.
- W4376223870 hasConcept C126322002 @default.
- W4376223870 hasConcept C133507102 @default.
- W4376223870 hasConcept C141071460 @default.
- W4376223870 hasConcept C197934379 @default.
- W4376223870 hasConcept C2776813522 @default.
- W4376223870 hasConcept C2777793932 @default.
- W4376223870 hasConcept C2779384505 @default.
- W4376223870 hasConcept C2779840525 @default.
- W4376223870 hasConcept C29730261 @default.
- W4376223870 hasConcept C509974204 @default.
- W4376223870 hasConcept C71924100 @default.
- W4376223870 hasConcept C90924648 @default.
- W4376223870 hasConceptScore W4376223870C116263406 @default.
- W4376223870 hasConceptScore W4376223870C121608353 @default.
- W4376223870 hasConceptScore W4376223870C126322002 @default.
- W4376223870 hasConceptScore W4376223870C133507102 @default.
- W4376223870 hasConceptScore W4376223870C141071460 @default.
- W4376223870 hasConceptScore W4376223870C197934379 @default.
- W4376223870 hasConceptScore W4376223870C2776813522 @default.
- W4376223870 hasConceptScore W4376223870C2777793932 @default.
- W4376223870 hasConceptScore W4376223870C2779384505 @default.
- W4376223870 hasConceptScore W4376223870C2779840525 @default.
- W4376223870 hasConceptScore W4376223870C29730261 @default.
- W4376223870 hasConceptScore W4376223870C509974204 @default.
- W4376223870 hasConceptScore W4376223870C71924100 @default.
- W4376223870 hasConceptScore W4376223870C90924648 @default.
- W4376223870 hasIssue "1" @default.
- W4376223870 hasLocation W43762238701 @default.
- W4376223870 hasLocation W43762238702 @default.
- W4376223870 hasOpenAccess W4376223870 @default.
- W4376223870 hasPrimaryLocation W43762238701 @default.
- W4376223870 hasRelatedWork W1979019365 @default.
- W4376223870 hasRelatedWork W1994364707 @default.
- W4376223870 hasRelatedWork W2145004298 @default.
- W4376223870 hasRelatedWork W2152506451 @default.
- W4376223870 hasRelatedWork W2293453490 @default.
- W4376223870 hasRelatedWork W2574725000 @default.
- W4376223870 hasRelatedWork W2953617526 @default.
- W4376223870 hasRelatedWork W3031152052 @default.
- W4376223870 hasRelatedWork W4376223870 @default.
- W4376223870 hasRelatedWork W55688459 @default.
- W4376223870 hasVolume "38" @default.
- W4376223870 isParatext "false" @default.
- W4376223870 isRetracted "false" @default.
- W4376223870 workType "article" @default.