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• W4376224450 endingPage "866" @default.
• W4376224450 startingPage "852" @default.
• W4376224450 abstract "This study aims to investigate the genetic polymorphism in the interleukin-17F (IL-17F) (rs763780, 7488 A/G) gene in bipolar disorder (BD) and schizophrenia (SCZ) patients by comparing it with healthy controls considering clinical parameters. A sample of 107 patients with BD, 129 patients with SCZ, and 100 healthy volunteers were included. SCID-I was used to confirm the diagnosis according to DSM-IV-TR criteria. The Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAM-D) were administered to BD patients. The Positive and Negative Symptoms Scale (PANSS) was applied to the patients with SCZ. PCR-RFLP was used to determine IL-17F gene polymorphism. Our results demonstrated that the distributions of the IL-17F genotype and the allele frequencies of BD patients were statistically significantly different from the control group. The AA genotype (OR: 0.283; 95% Cl: 0.140–0.573; p<.001) and A allele (OR: 0.333; 95% Cl: 0.171–0.646; p=.001) frequencies were significantly higher in the control group than in the BD group. The IL-17F genotype and the allele frequency distributions of SCZ patients were not statistically significantly different from the control group. When comparing scale scores due to the IL-17F genotype distributions in patients with BD or SCZ, there was no statistically significant difference between the groups of IL-17F genotypes. In summary, whereas the IL-17F polymorphism may be associated with BD, this polymorphism was not related to SCZ." @default.
• W4376224450 created "2023-05-13" @default.
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• W4376224450 date "2023-05-12" @default.
• W4376224450 modified "2023-10-18" @default.
• W4376224450 title "Genetic polymorphism of <i>IL-17F</i> rs763780 contributes to the susceptibility to bipolar disorder but not to schizophrenia in the Turkish population" @default.
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• W4376224450 doi "https://doi.org/10.1080/15257770.2023.2211124" @default.
• W4376224450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37171073" @default.
• W4376224450 hasPublicationYear "2023" @default.
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