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- W4376225932 abstract "Immunosuppressive tumor microenvironments (TMEs) reduce the effectiveness of immune responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated fibroblasts (CAFs), promote tumor progression by enhancing immune cell suppression in colorectal cancer (CRC). Hyper-sialylation of glycans promotes immune evasion in cancer through binding of sialic acids to their receptors, Siglecs, expressed on immune cells, which results in inhibition of effector functions. The role of sialylation in shaping MSC/CAF immunosuppression in the TME is not well characterized. In this study, we show that tumor-conditioned stromal cells have increased sialyltransferase expression, α2,3/6-linked sialic acid, and Siglec ligands. Tumor-conditioned stromal cells and CAFs induce exhausted immunomodulatory CD8+ PD1+ and CD8+ Siglec-7+/Siglec-9+ T cell phenotypes. In vivo, targeting stromal cell sialylation reverses stromal cell-mediated immunosuppression, as shown by infiltration of CD25 and granzyme B-expressing CD8+ T cells in the tumor and draining lymph node. Targeting stromal cell sialylation may overcome immunosuppression in the CRC TME." @default.
- W4376225932 created "2023-05-13" @default.
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- W4376225932 date "2023-05-01" @default.
- W4376225932 modified "2023-10-16" @default.
- W4376225932 title "Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment" @default.
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- W4376225932 cites W1954731853 @default.
- W4376225932 cites W1971907885 @default.
- W4376225932 cites W1975203568 @default.
- W4376225932 cites W1982056508 @default.
- W4376225932 cites W1990068362 @default.
- W4376225932 cites W1997944110 @default.
- W4376225932 cites W2024326908 @default.
- W4376225932 cites W2037900813 @default.
- W4376225932 cites W2071173881 @default.
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- W4376225932 cites W2114843025 @default.
- W4376225932 cites W2117997562 @default.
- W4376225932 cites W2126381976 @default.
- W4376225932 cites W2132105937 @default.
- W4376225932 cites W2142300779 @default.
- W4376225932 cites W2144577119 @default.
- W4376225932 cites W2149441684 @default.
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- W4376225932 cites W2314057593 @default.
- W4376225932 cites W2318212002 @default.
- W4376225932 cites W2339192674 @default.
- W4376225932 cites W2342494521 @default.
- W4376225932 cites W2404697704 @default.
- W4376225932 cites W2507144075 @default.
- W4376225932 cites W2508974650 @default.
- W4376225932 cites W2515851707 @default.
- W4376225932 cites W2516359951 @default.
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- W4376225932 cites W2787237920 @default.
- W4376225932 cites W2790543400 @default.
- W4376225932 cites W2802305216 @default.
- W4376225932 cites W2807859574 @default.
- W4376225932 cites W2888330968 @default.
- W4376225932 cites W2891853646 @default.
- W4376225932 cites W2902489593 @default.
- W4376225932 cites W2905821037 @default.
- W4376225932 cites W2921437380 @default.
- W4376225932 cites W2924629148 @default.
- W4376225932 cites W2936819375 @default.
- W4376225932 cites W2948998183 @default.
- W4376225932 cites W2950313841 @default.
- W4376225932 cites W2952481429 @default.
- W4376225932 cites W2969726961 @default.
- W4376225932 cites W2971559630 @default.
- W4376225932 cites W3008826523 @default.
- W4376225932 cites W3010474975 @default.
- W4376225932 cites W3021927596 @default.
- W4376225932 cites W3029301893 @default.
- W4376225932 cites W3046307945 @default.
- W4376225932 cites W3048973619 @default.
- W4376225932 cites W3090720142 @default.
- W4376225932 cites W3095097659 @default.
- W4376225932 cites W3121051888 @default.
- W4376225932 cites W3125874893 @default.
- W4376225932 cites W3131248149 @default.
- W4376225932 cites W3132035386 @default.
- W4376225932 cites W3163962956 @default.
- W4376225932 cites W3169296854 @default.
- W4376225932 cites W3174289113 @default.