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• W4376226095 abstract "Abstract Ultraviolet (UV) light primarily causes C &gt; T substitutions in lesion-forming dipyrimidine sequences. However, many of the key driver mutations in melanoma do not fit this canonical UV signature, but are instead caused by T &gt; A, T &gt; C, or C &gt; A substitutions. To what extent exposure to the UVB or UVA spectrum of sunlight can induce these noncanonical mutation classes, and the molecular mechanism involved is unclear. Here, we repeatedly exposed wild-type or repair-deficient yeast (Saccharomyces cerevisiae) to UVB or UVA light and characterized the resulting mutations by whole genome sequencing. Our data indicate that UVB induces C &gt; T and T &gt; C substitutions in dipyrimidines, and T &gt; A substitutions that are often associated with thymine–adenine (TA) sequences. All of these mutation classes are induced in nucleotide excision repair–deficient cells and show transcriptional strand asymmetry, suggesting they are caused by helix-distorting UV photoproducts. In contrast, UVA exposure induces orders of magnitude fewer mutations with a distinct mutation spectrum. UVA-induced mutations are elevated in Ogg1-deficient cells, and the resulting spectrum consists almost entirely of C &gt; A/G &gt; T mutations, indicating they are likely derived from oxidative guanine lesions. These mutations show replication asymmetry, with elevated G &gt; T mutations on the leading strand, suggesting there is a strand bias in the removal or bypass of guanine lesions during replication. Finally, we develop a mutation reporter to show that UVA induces a G &gt; T reversion mutation in yeast that mimics the oncogenic NRAS Q61K mutation in melanoma. Taken together, these findings indicate that UVA and UVB exposure can induce many of the noncanonical mutation classes that cause driver mutations in melanoma." @default.
• W4376226095 created "2023-05-13" @default.
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• W4376226095 date "2023-05-12" @default.
• W4376226095 modified "2023-10-17" @default.
• W4376226095 title "Genome-wide maps of UVA and UVB mutagenesis in yeast reveal distinct causative lesions and mutational strand asymmetries" @default.
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• W4376226095 doi "https://doi.org/10.1093/genetics/iyad086" @default.
• W4376226095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37170598" @default.
• W4376226095 hasPublicationYear "2023" @default.
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