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- W4376226711 abstract "Abstract The peroxisome is a ubiquitous organelle in rodent cells and plays important roles in a variety of cell types and tissues. It is previously indicated that peroxisomes are associated with auditory function, and patients with peroxisome biogenesis disorders (PBDs) are found to have hearing dysfunction, but the specific role of peroxisomes in hearing remains unclear. In this study, two peroxisome‐deficient mouse models ( Atoh1‐Pex5 −/− and Pax2‐Pex5 −/− ) are established and it is found that peroxisomes mainly function in the hair cells of cochleae. Furthermore, peroxisome deficiency‐mediated negative effects on hearing do not involve mitochondrial dysfunction and oxidative damage. Although the mammalian target of rapamycin complex 1 (mTORC1) signaling is shown to function through peroxisomes, no changes are observed in the mTORC1 signaling in Atoh1‐Pex5 −/‐ mice when compared to wild‐type (WT) mice. However, the expression of large‐conductance, voltage‐, and Ca2 + ‐activated K + (BK) channels is less in Atoh1‐Pex5 −/− mice as compared to the WT mice, and the administration of activators of BK channels (NS‐1619 and NS‐11021) restores the auditory function in knockout mice. These results suggest that peroxisomes play an essential role in cochlear hair cells by regulating BK channels. Hence, BK channels appear as the probable target for treating peroxisome‐related hearing diseases such as PBDs." @default.
- W4376226711 created "2023-05-13" @default.
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- W4376226711 date "2023-05-12" @default.
- W4376226711 modified "2023-10-17" @default.
- W4376226711 title "Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels" @default.
- W4376226711 cites W1771754722 @default.
- W4376226711 cites W184565012 @default.
- W4376226711 cites W1931092714 @default.
- W4376226711 cites W1964697500 @default.
- W4376226711 cites W1968542784 @default.
- W4376226711 cites W1971817019 @default.
- W4376226711 cites W1978365198 @default.
- W4376226711 cites W1979269349 @default.
- W4376226711 cites W1979904471 @default.
- W4376226711 cites W1986733224 @default.
- W4376226711 cites W1991084221 @default.
- W4376226711 cites W1992716449 @default.
- W4376226711 cites W2009945015 @default.
- W4376226711 cites W2017614800 @default.
- W4376226711 cites W2023067699 @default.
- W4376226711 cites W2026889343 @default.
- W4376226711 cites W2027318031 @default.
- W4376226711 cites W2040365013 @default.
- W4376226711 cites W2049115878 @default.
- W4376226711 cites W2059898382 @default.
- W4376226711 cites W2072443346 @default.
- W4376226711 cites W2073853461 @default.
- W4376226711 cites W2090405680 @default.
- W4376226711 cites W2101355612 @default.
- W4376226711 cites W2109713300 @default.
- W4376226711 cites W2113001708 @default.
- W4376226711 cites W2114946849 @default.
- W4376226711 cites W2115027228 @default.
- W4376226711 cites W2116016749 @default.
- W4376226711 cites W2120111943 @default.
- W4376226711 cites W2122751786 @default.
- W4376226711 cites W2124956869 @default.
- W4376226711 cites W2128396778 @default.
- W4376226711 cites W2146961403 @default.
- W4376226711 cites W2146980664 @default.
- W4376226711 cites W2147734210 @default.
- W4376226711 cites W2148291968 @default.
- W4376226711 cites W2155414337 @default.
- W4376226711 cites W2155479958 @default.
- W4376226711 cites W2262335045 @default.
- W4376226711 cites W2466441120 @default.
- W4376226711 cites W2531843007 @default.
- W4376226711 cites W2556680395 @default.
- W4376226711 cites W2607063758 @default.
- W4376226711 cites W2611066600 @default.
- W4376226711 cites W2737209541 @default.
- W4376226711 cites W2770237663 @default.
- W4376226711 cites W2800628417 @default.
- W4376226711 cites W2888314807 @default.
- W4376226711 cites W2891301827 @default.
- W4376226711 cites W2895872801 @default.
- W4376226711 cites W2938579578 @default.
- W4376226711 cites W2971172765 @default.
- W4376226711 cites W2981295718 @default.
- W4376226711 cites W3004007146 @default.
- W4376226711 cites W3081336401 @default.
- W4376226711 cites W3087176574 @default.
- W4376226711 cites W3107177179 @default.
- W4376226711 cites W3118656804 @default.
- W4376226711 cites W3128495817 @default.
- W4376226711 cites W3211041254 @default.
- W4376226711 cites W4200150356 @default.
- W4376226711 cites W4200411106 @default.
- W4376226711 cites W4207020351 @default.
- W4376226711 cites W4210823379 @default.
- W4376226711 cites W4224924642 @default.
- W4376226711 cites W4225979443 @default.
- W4376226711 cites W4281858852 @default.
- W4376226711 cites W4289836579 @default.
- W4376226711 cites W4304141608 @default.
- W4376226711 cites W4306149810 @default.
- W4376226711 cites W4306874563 @default.
- W4376226711 cites W4308181758 @default.
- W4376226711 cites W4311601716 @default.
- W4376226711 cites W4376226711 @default.