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• W4376256512 endingPage "1766" @default.
• W4376256512 startingPage "1755" @default.
• W4376256512 abstract "DNA adopts a number of conformations that can affect its binding to other macromolecules. The conformations (A, B, Z) can be sequence- and/or solution-dependent. While AT-rich DNA sequences generally adopt a Canonical B-form structure, GC-rich sequences are more promiscuous. Recognition of GC-rich nucleic acids by small molecules has been much more challenging than the recognition of AT-rich duplexes. Spectrophotometric and calorimetric techniques were used to characterize the binding of neomycin-class aminoglycosides to a GC-rich DNA duplex, G4C4, in various ionic and pH conditions. Our results reveal that binding enhances the thermal stability of G4C4, with thermal enhancement decreasing with increasing pH and/or Na+ concentration. Although G4C4 bound to aminoglycosides demonstrated a mixed A- and B-form conformation, circular dichroism studies indicate that binding induces a conformational shift toward A-form DNA. Isothermal titration calorimetry studies reveal that aminoglycoside binding to G4C4 is linked to the uptake of protons at pH = 7.0 and that this uptake is pH-dependent. Increased pH and/or Na+ concentration results in a decrease in G4C4 affinity for the aminoglycosides. The binding affinities of the aminoglycosides follow the expected hierarchy: neomycin > paromomycin > ribostamycin. The salt dependence of DNA binding affinities of aminoglycosides is consistent with at least two drug NH3+ groups participating in electrostatic interactions with G4C4. These studies further embellish our understanding of the many factors facilitating recognition of GC-rich DNA structures as guided by their optimum charge and shape complementarity for small-molecule amino sugars." @default.
• W4376256512 created "2023-05-13" @default.
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• W4376256512 date "2023-05-12" @default.
• W4376256512 modified "2023-10-14" @default.
• W4376256512 title "Thermodynamics of d(GGGGCCCC) Binding to Neomycin-Class Aminoglycosides" @default.
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• W4376256512 doi "https://doi.org/10.1021/acs.biochem.3c00049" @default.
• W4376256512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37172221" @default.
• W4376256512 hasPublicationYear "2023" @default.
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