FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376270717> ?p ?o ?g. }

• W4376270717 abstract "Lysophosphatidic acid (LPA) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid Receptors [62, 23, 91, 144]) are activated by the endogenous phospholipid LPA. The first receptor, LPA1, was identified as ventricular zone gene-1 (vzg-1) [46], This discovery represented the beginning of the de-orphanisation of members of the endothelial differentiation gene (edg) family, as other LPA and sphingosine 1-phosphate (S1P) receptors were found. Five additional LPA receptors (LPA2,3,4,5,6) have since been identified [91] and their gene nomenclature codified for human LPAR1, LPAR2, etc. (HUGO Gene Nomenclature Committee, HGNC) and Lpar1, Lpar2, etc. for mice (Mouse Genome Informatics Database, MGI) to reflect species and receptor function of their corresponding proteins. The crystal structure of LPA1 [17, 80, 2] and LPA6 [128] are solved and indicate that LPA accesses the extracellular binding pocket, consistent with its proposed delivery via autotaxin [17]. These studies have also implicated cross-talk with endocannabinoids via phosphorylated intermediates that can also activate these receptors. The binding affinities to LPA1 of unlabeled, natural LPA and anandamide phosphate (AEAp) were measured using backscattering interferometry (pKd = 9) [92, 115]. Utilization of this method indicated affinities that were 77-fold lower than when measured using radioactivity-based protocols [143]. Targeted deletion of LPA receptors has clarified signalling pathways and identified physiological and pathophysiological roles. Multiple groups have independently published validation of all six LPA receptors described in these tables, and further validation was achieved using a distinct read-out via a novel TGFα shedding* assay [54]. LPA has been proposed to be a ligand for GPR35 [103], supported by a study revealing that LPA modulates macrophage function through GPR35 [60]. However chemokine (C-X-C motif) ligand 17 (CXCL17) is reported to be a ligand for GPR35/CXCR8 [85]. Moreover, LPA has also been described as an agonist for the transient receptor potential (Trp) ion channels TRPV1 [96] and TRPA1 [65]. All of these proposed non-GPCR receptor identities require confirmation and are not currently recognized as bona fide LPA receptors." @default.
• W4376270717 created "2023-05-13" @default.
• W4376270717 creator A5006952722 @default.
• W4376270717 creator A5012522794 @default.
• W4376270717 creator A5014799222 @default.
• W4376270717 creator A5053432777 @default.
• W4376270717 creator A5059670809 @default.
• W4376270717 date "2023-04-26" @default.
• W4376270717 modified "2023-09-30" @default.
• W4376270717 title "Lysophospholipid (LPA) receptors in GtoPdb v.2023.1" @default.
• W4376270717 doi "https://doi.org/10.2218/gtopdb/f36/2023.1" @default.
• W4376270717 hasPublicationYear "2023" @default.
• W4376270717 type Work @default.
• W4376270717 citedByCount "0" @default.
• W4376270717 crossrefType "journal-article" @default.
• W4376270717 hasAuthorship W4376270717A5006952722 @default.
• W4376270717 hasAuthorship W4376270717A5012522794 @default.
• W4376270717 hasAuthorship W4376270717A5014799222 @default.
• W4376270717 hasAuthorship W4376270717A5053432777 @default.
• W4376270717 hasAuthorship W4376270717A5059670809 @default.
• W4376270717 hasBestOaLocation W43762707171 @default.
• W4376270717 hasConcept C135285700 @default.
• W4376270717 hasConcept C170493617 @default.
• W4376270717 hasConcept C185592680 @default.
• W4376270717 hasConcept C203270574 @default.
• W4376270717 hasConcept C26702167 @default.
• W4376270717 hasConcept C2776661833 @default.
• W4376270717 hasConcept C2778938600 @default.
• W4376270717 hasConcept C37547375 @default.
• W4376270717 hasConcept C55493867 @default.
• W4376270717 hasConcept C86803240 @default.
• W4376270717 hasConcept C95444343 @default.
• W4376270717 hasConceptScore W4376270717C135285700 @default.
• W4376270717 hasConceptScore W4376270717C170493617 @default.
• W4376270717 hasConceptScore W4376270717C185592680 @default.
• W4376270717 hasConceptScore W4376270717C203270574 @default.
• W4376270717 hasConceptScore W4376270717C26702167 @default.
• W4376270717 hasConceptScore W4376270717C2776661833 @default.
• W4376270717 hasConceptScore W4376270717C2778938600 @default.
• W4376270717 hasConceptScore W4376270717C37547375 @default.
• W4376270717 hasConceptScore W4376270717C55493867 @default.
• W4376270717 hasConceptScore W4376270717C86803240 @default.
• W4376270717 hasConceptScore W4376270717C95444343 @default.
• W4376270717 hasIssue "1" @default.
• W4376270717 hasLocation W43762707171 @default.
• W4376270717 hasOpenAccess W4376270717 @default.
• W4376270717 hasPrimaryLocation W43762707171 @default.
• W4376270717 hasRelatedWork W1950270734 @default.
• W4376270717 hasRelatedWork W1975673341 @default.
• W4376270717 hasRelatedWork W2067239619 @default.
• W4376270717 hasRelatedWork W2098565708 @default.
• W4376270717 hasRelatedWork W2159623504 @default.
• W4376270717 hasRelatedWork W2973742877 @default.
• W4376270717 hasRelatedWork W3174206326 @default.
• W4376270717 hasRelatedWork W3203320362 @default.
• W4376270717 hasRelatedWork W4234866922 @default.
• W4376270717 hasRelatedWork W4376270717 @default.
• W4376270717 hasVolume "2023" @default.
• W4376270717 isParatext "false" @default.
• W4376270717 isRetracted "false" @default.
• W4376270717 workType "article" @default.