FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376272019> ?p ?o ?g. }

• W4376272019 abstract "Abstract Marfan syndrome causes a hereditary form of thoracic aortic aneurysms with dilation of the aortic root. Human and animal models suggest a worse phenotype for males compared to females with respect to aneurysm size and risk of dissection. In this study we examine the effects of 17 β-estradiol on aortic dilation and rupture in a Marfan mouse model. Marfan male mice were administered 17 β-estradiol and the growth in aortic root size along with the risk of aortic rupture or dissection with the addition of angiotensin II was measured. Transcriptomic profiling was used to identify enriched pathways from 17 β-estradiol treatment. Aortic smooth muscle cells were then treated with cytokines in order to validate the mechanism of 17 β-estradiol protection. We show that 17 β-estradiol decreased the size and rate of aortic root dilation and improved survival from rupture and dissection after treatment with angiotensin II. The Marfan transcriptome was enriched in inflammatory genes and the addition of 17 β-estradiol modulated a set of genes that function through TNFα mediated NF-κB signaling. These included many proteins known to play a role in the phenotypic shift of aortic smooth muscle cells from a contractile to a more inflammatory-like state such as Vcam-1, Mcp-1, Lgals3, Il-6, Il-1b, and C3. In addition, 17 β-estradiol suppressed the induction of these TNFα induced genes in aortic smooth muscle cells in vitro and this effect appears to be NF-κB dependent. In conclusion, 17 β-estradiol protects against the dilation and rupture of aortic roots in Marfan male mice through the inhibition of TNFα -NF-κB signaling and thus prevents the phenotypic switch of aortic smooth muscle cells from a contractile to an inflammatory state." @default.
• W4376272019 created "2023-05-13" @default.
• W4376272019 creator A5010132049 @default.
• W4376272019 creator A5011179811 @default.
• W4376272019 creator A5017247435 @default.
• W4376272019 creator A5037822438 @default.
• W4376272019 creator A5042034622 @default.
• W4376272019 creator A5045322245 @default.
• W4376272019 creator A5091929410 @default.
• W4376272019 date "2023-05-12" @default.
• W4376272019 modified "2023-10-18" @default.
• W4376272019 title "17 β-estradiol impedes aortic root dilation and rupture in male Marfan mice" @default.
• W4376272019 cites W1967171675 @default.
• W4376272019 cites W1976795428 @default.
• W4376272019 cites W1996316514 @default.
• W4376272019 cites W2006182121 @default.
• W4376272019 cites W2007853914 @default.
• W4376272019 cites W2019965602 @default.
• W4376272019 cites W2021177693 @default.
• W4376272019 cites W2036954913 @default.
• W4376272019 cites W2059730368 @default.
• W4376272019 cites W2070050178 @default.
• W4376272019 cites W2084899012 @default.
• W4376272019 cites W2093938367 @default.
• W4376272019 cites W2108808942 @default.
• W4376272019 cites W2123878234 @default.
• W4376272019 cites W2124138031 @default.
• W4376272019 cites W2130410032 @default.
• W4376272019 cites W2140729960 @default.
• W4376272019 cites W2153220619 @default.
• W4376272019 cites W2159620446 @default.
• W4376272019 cites W2160065782 @default.
• W4376272019 cites W2179438025 @default.
• W4376272019 cites W2466879592 @default.
• W4376272019 cites W2512227186 @default.
• W4376272019 cites W2555437426 @default.
• W4376272019 cites W2585605719 @default.
• W4376272019 cites W2602881781 @default.
• W4376272019 cites W2626757669 @default.
• W4376272019 cites W2769974544 @default.
• W4376272019 cites W3092877608 @default.
• W4376272019 cites W3208339437 @default.
• W4376272019 cites W4221030787 @default.
• W4376272019 cites W4247882080 @default.
• W4376272019 cites W4254687493 @default.
• W4376272019 cites W4256509992 @default.
• W4376272019 cites W4309654956 @default.
• W4376272019 doi "https://doi.org/10.1101/2023.05.09.540071" @default.
• W4376272019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37215011" @default.
• W4376272019 hasPublicationYear "2023" @default.
• W4376272019 type Work @default.
• W4376272019 citedByCount "0" @default.
• W4376272019 crossrefType "posted-content" @default.
• W4376272019 hasAuthorship W4376272019A5010132049 @default.
• W4376272019 hasAuthorship W4376272019A5011179811 @default.
• W4376272019 hasAuthorship W4376272019A5017247435 @default.
• W4376272019 hasAuthorship W4376272019A5037822438 @default.
• W4376272019 hasAuthorship W4376272019A5042034622 @default.
• W4376272019 hasAuthorship W4376272019A5045322245 @default.
• W4376272019 hasAuthorship W4376272019A5091929410 @default.
• W4376272019 hasBestOaLocation W43762720191 @default.
• W4376272019 hasConcept C104317684 @default.
• W4376272019 hasConcept C126322002 @default.
• W4376272019 hasConcept C134018914 @default.
• W4376272019 hasConcept C150194340 @default.
• W4376272019 hasConcept C162317418 @default.
• W4376272019 hasConcept C164705383 @default.
• W4376272019 hasConcept C170493617 @default.
• W4376272019 hasConcept C2777323849 @default.
• W4376272019 hasConcept C2778745619 @default.
• W4376272019 hasConcept C2779980429 @default.
• W4376272019 hasConcept C2779993142 @default.
• W4376272019 hasConcept C2780561598 @default.
• W4376272019 hasConcept C2908929049 @default.
• W4376272019 hasConcept C55493867 @default.
• W4376272019 hasConcept C71924100 @default.
• W4376272019 hasConcept C86803240 @default.
• W4376272019 hasConceptScore W4376272019C104317684 @default.
• W4376272019 hasConceptScore W4376272019C126322002 @default.
• W4376272019 hasConceptScore W4376272019C134018914 @default.
• W4376272019 hasConceptScore W4376272019C150194340 @default.
• W4376272019 hasConceptScore W4376272019C162317418 @default.
• W4376272019 hasConceptScore W4376272019C164705383 @default.
• W4376272019 hasConceptScore W4376272019C170493617 @default.
• W4376272019 hasConceptScore W4376272019C2777323849 @default.
• W4376272019 hasConceptScore W4376272019C2778745619 @default.
• W4376272019 hasConceptScore W4376272019C2779980429 @default.
• W4376272019 hasConceptScore W4376272019C2779993142 @default.
• W4376272019 hasConceptScore W4376272019C2780561598 @default.
• W4376272019 hasConceptScore W4376272019C2908929049 @default.
• W4376272019 hasConceptScore W4376272019C55493867 @default.
• W4376272019 hasConceptScore W4376272019C71924100 @default.
• W4376272019 hasConceptScore W4376272019C86803240 @default.
• W4376272019 hasLocation W43762720191 @default.
• W4376272019 hasLocation W43762720192 @default.
• W4376272019 hasLocation W43762720193 @default.
• W4376272019 hasOpenAccess W4376272019 @default.
• W4376272019 hasPrimaryLocation W43762720191 @default.
• W4376272019 hasRelatedWork W198115119 @default.
• W4376272019 hasRelatedWork W1998783394 @default.

• next