Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376272502> ?p ?o ?g. }
- W4376272502 abstract "ABSTRACT Maternal choline supplementation (MCS) improves cognition in Alzheimer’s disease (AD) models. However, effects of MCS on neuronal hyperexcitability in AD are unknown. We investigated effects of MCS in a well-established mouse model of AD with hyperexcitability, the Tg2576 mouse. The most common type of hyperexcitability in Tg2576 mice, and many other mouse models and AD patients, are generalized EEG spikes (interictal spikes; IIS). Hyperexcitability is also reflected by elevated expression of the transcription factor ΔFosB in the principal cells of the dentate gyrus (DG), granule cells (GCs). We also studied the hilus of the DG because hilar neurons regulate GC excitability. We found reduced expression of the neuronal marker NeuN within hilar neurons in Tg2576 mice, which other studies have shown is a sign of oxidative stress or other pathology. Tg2576 breeding pairs received a diet with a relatively low, intermediate or high concentration of choline. After weaning, all mice received the intermediate diet. In offspring of mice fed the high choline diet, IIS frequency declined, GC ΔFosB expression was reduced, and NeuN expression restored. Spatial memory improved. In contrast, offspring exposed to the relatively low choline diet had several adverse effects, such as increased mortality. The results provide new evidence that a diet high in choline in early life can improve outcomes in a mouse model of AD, and relatively low choline can have negative consequences. This is the first study showing that dietary choline can regulate hyperexcitability, hilar neurons, and spatial memory in an animal model of AD." @default.
- W4376272502 created "2023-05-13" @default.
- W4376272502 creator A5010334407 @default.
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- W4376272502 creator A5079569151 @default.
- W4376272502 date "2023-05-12" @default.
- W4376272502 modified "2023-10-18" @default.
- W4376272502 title "Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease" @default.
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