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- W4376273689 endingPage "188912" @default.
- W4376273689 startingPage "188912" @default.
- W4376273689 abstract "The dysregulation of the cell cycle is one of the hallmarks of cancer. Cyclin-dependent kinase 4 (CDK4) and CDK6 play crucial roles in regulating cell cycle and other cellular functions. CDK4/6 inhibitors have achieved great success in treating breast cancers and are currently being tested extensively in other tumor types as well. Accumulating evidence suggests that CDK4/6 inhibitors exert antitumor effects through immunomodulation aside from cell cycle arrest. Here we outline the immunomodulatory activities of CDK4/6 inhibitors, discuss the immune mechanisms of drug resistance and explore avenues to harness their immunotherapeutic potential when combined with immune checkpoint inhibitors (ICIs) or chimeric antigen receptor (CAR) T-cell therapy to improve the clinical outcomes." @default.
- W4376273689 created "2023-05-13" @default.
- W4376273689 creator A5009863367 @default.
- W4376273689 creator A5019382001 @default.
- W4376273689 creator A5023105695 @default.
- W4376273689 creator A5027579152 @default.
- W4376273689 creator A5074236154 @default.
- W4376273689 date "2023-07-01" @default.
- W4376273689 modified "2023-10-16" @default.
- W4376273689 title "Immunomodulatory effects of CDK4/6 inhibitors" @default.
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