Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376274101> ?p ?o ?g. }
- W4376274101 endingPage "113347" @default.
- W4376274101 startingPage "113347" @default.
- W4376274101 abstract "Radiotherapy (RT) efficacy can be promoted with the help of nanoenzyme that can re-programing the tumour's micro-environment by changing the expression level of special bio-molecules. However, problems such as low reaction efficiency, limited endogenous H2O2, and/or unsatisfactory results of a single catalysis mode in treatment limit the application in the RT field. Herein, a novel Au nanoparticles (AuNPs) decorated iron SAE (FeSAE@Au) was formulated for self-cascade catalytic RT. In this dual-nanozyme system, embedded AuNPs can sever as GOx and endow FeSAE@Au with self-H2O2 supplying ability, which can elevate the H2O2 level in tumors by catalyzing cellular glucose in situ, further improving the catalytic performance of FeSAE with peroxidase-like activity. The self-cascade catalytic reaction can significantly increase cellular hydroxyl radicals (•OH) level, further promoting RT's effect. Furthermore, in vivo findings demonstrated that FeSAE can effectively limit tumor growth while causing low damage in important organs. According to our understanding, FeSAE@Au is the first description of a hybrid SAE-based nanomaterial employed in cascade catalytic RT. The research yields new and interesting insights for developing various SAE systems for anticancer therapy." @default.
- W4376274101 created "2023-05-13" @default.
- W4376274101 creator A5001713450 @default.
- W4376274101 creator A5004143412 @default.
- W4376274101 creator A5024637740 @default.
- W4376274101 creator A5032642837 @default.
- W4376274101 creator A5064436064 @default.
- W4376274101 creator A5085445983 @default.
- W4376274101 creator A5091929809 @default.
- W4376274101 date "2023-07-01" @default.
- W4376274101 modified "2023-09-26" @default.
- W4376274101 title "Self-cascade catalytic single-atom nanozyme for enhanced breast cancer low-dose radiotherapy" @default.
- W4376274101 cites W2116005833 @default.
- W4376274101 cites W2170913114 @default.
- W4376274101 cites W2550440327 @default.
- W4376274101 cites W2561211596 @default.
- W4376274101 cites W2770840849 @default.
- W4376274101 cites W2780958320 @default.
- W4376274101 cites W2883440571 @default.
- W4376274101 cites W2888164701 @default.
- W4376274101 cites W2915214302 @default.
- W4376274101 cites W2951928817 @default.
- W4376274101 cites W2993510745 @default.
- W4376274101 cites W2994778613 @default.
- W4376274101 cites W2998992532 @default.
- W4376274101 cites W3015283272 @default.
- W4376274101 cites W3023757275 @default.
- W4376274101 cites W3045888043 @default.
- W4376274101 cites W3119269938 @default.
- W4376274101 cites W3128836147 @default.
- W4376274101 cites W3135410806 @default.
- W4376274101 cites W3143176399 @default.
- W4376274101 cites W3155725731 @default.
- W4376274101 cites W3160226953 @default.
- W4376274101 cites W3174128215 @default.
- W4376274101 cites W3177225755 @default.
- W4376274101 cites W3191844992 @default.
- W4376274101 cites W3195548726 @default.
- W4376274101 cites W3197159314 @default.
- W4376274101 cites W3199586803 @default.
- W4376274101 cites W3217805896 @default.
- W4376274101 cites W4205259704 @default.
- W4376274101 cites W4220694069 @default.
- W4376274101 cites W4225693815 @default.
- W4376274101 cites W4280580780 @default.
- W4376274101 cites W4281489131 @default.
- W4376274101 cites W4285118295 @default.
- W4376274101 doi "https://doi.org/10.1016/j.colsurfb.2023.113347" @default.
- W4376274101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37196465" @default.
- W4376274101 hasPublicationYear "2023" @default.
- W4376274101 type Work @default.
- W4376274101 citedByCount "0" @default.
- W4376274101 crossrefType "journal-article" @default.
- W4376274101 hasAuthorship W4376274101A5001713450 @default.
- W4376274101 hasAuthorship W4376274101A5004143412 @default.
- W4376274101 hasAuthorship W4376274101A5024637740 @default.
- W4376274101 hasAuthorship W4376274101A5032642837 @default.
- W4376274101 hasAuthorship W4376274101A5064436064 @default.
- W4376274101 hasAuthorship W4376274101A5085445983 @default.
- W4376274101 hasAuthorship W4376274101A5091929809 @default.
- W4376274101 hasConcept C104819515 @default.
- W4376274101 hasConcept C119128265 @default.
- W4376274101 hasConcept C121608353 @default.
- W4376274101 hasConcept C126322002 @default.
- W4376274101 hasConcept C138631740 @default.
- W4376274101 hasConcept C139066938 @default.
- W4376274101 hasConcept C150903083 @default.
- W4376274101 hasConcept C155672457 @default.
- W4376274101 hasConcept C161790260 @default.
- W4376274101 hasConcept C171250308 @default.
- W4376274101 hasConcept C178790620 @default.
- W4376274101 hasConcept C185592680 @default.
- W4376274101 hasConcept C192562407 @default.
- W4376274101 hasConcept C207001950 @default.
- W4376274101 hasConcept C21951064 @default.
- W4376274101 hasConcept C2993359049 @default.
- W4376274101 hasConcept C3019816032 @default.
- W4376274101 hasConcept C34146451 @default.
- W4376274101 hasConcept C43617362 @default.
- W4376274101 hasConcept C509974204 @default.
- W4376274101 hasConcept C71924100 @default.
- W4376274101 hasConcept C86803240 @default.
- W4376274101 hasConceptScore W4376274101C104819515 @default.
- W4376274101 hasConceptScore W4376274101C119128265 @default.
- W4376274101 hasConceptScore W4376274101C121608353 @default.
- W4376274101 hasConceptScore W4376274101C126322002 @default.
- W4376274101 hasConceptScore W4376274101C138631740 @default.
- W4376274101 hasConceptScore W4376274101C139066938 @default.
- W4376274101 hasConceptScore W4376274101C150903083 @default.
- W4376274101 hasConceptScore W4376274101C155672457 @default.
- W4376274101 hasConceptScore W4376274101C161790260 @default.
- W4376274101 hasConceptScore W4376274101C171250308 @default.
- W4376274101 hasConceptScore W4376274101C178790620 @default.
- W4376274101 hasConceptScore W4376274101C185592680 @default.
- W4376274101 hasConceptScore W4376274101C192562407 @default.
- W4376274101 hasConceptScore W4376274101C207001950 @default.
- W4376274101 hasConceptScore W4376274101C21951064 @default.
- W4376274101 hasConceptScore W4376274101C2993359049 @default.