Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376274906> ?p ?o ?g. }
- W4376274906 endingPage "8694" @default.
- W4376274906 startingPage "8694" @default.
- W4376274906 abstract "Medication-related osteonecrosis of the jaw (MRONJ) is a severe disease with unclear pathogenesis. Adipose tissue-derived mesenchymal stromal cells (MSC(AT)s) serve as a special source for cell therapy. Herein, we explored whether exosomes (Exo) derived from MSC(AT)s promote primary gingival wound healing and prevent MRONJ. An MRONJ mice model was constructed using zoledronate (Zol) administration and tooth extraction. Exosomes were collected from the conditioned medium (CM) of MSC(AT)s (MSC(AT)s-Exo) and locally administered into the tooth sockets. Interleukin-1 receptor antagonist (IL-1RA)-siRNA was used to knock down the expression of IL-1RA in MSC(AT)s-Exo. Clinical observations, micro-computed tomography (microCT), and histological analysis were used to evaluate the therapeutic effects in vivo. In addition, the effect of exosomes on the biological behavior of human gingival fibroblasts (HGFs) was evaluated in vitro. MSC(AT)s-Exo accelerated primary gingival wound healing and bone regeneration in tooth sockets and prevented MRONJ. Moreover, MSC(AT)s-Exo increased IL-1RA expression and decreased interleukin-1 beta (IL-1β) and tumor necrosis factor-α (TNF-α) expression in the gingival tissue. The sequent rescue assay showed that the effects of preventing MRONJ in vivo and improving the migration and collagen synthesis abilities of zoledronate-affected HGFs in vitro were partially impaired in the IL-1RA-deficient exosome group. Our results indicated that MSC(AT)s-Exo might prevent the onset of MRONJ via an IL-1RA-mediated anti-inflammatory effect in the gingiva wound and improve the migration and collagen synthesis abilities of HGFs." @default.
- W4376274906 created "2023-05-13" @default.
- W4376274906 creator A5016438972 @default.
- W4376274906 creator A5021984184 @default.
- W4376274906 creator A5028933668 @default.
- W4376274906 creator A5030849116 @default.
- W4376274906 creator A5044544424 @default.
- W4376274906 creator A5061250894 @default.
- W4376274906 creator A5061664204 @default.
- W4376274906 creator A5069952203 @default.
- W4376274906 creator A5075877965 @default.
- W4376274906 date "2023-05-12" @default.
- W4376274906 modified "2023-10-11" @default.
- W4376274906 title "Exosomes Derived from Adipose Tissue-Derived Mesenchymal Stromal Cells Prevent Medication-Related Osteonecrosis of the Jaw through IL-1RA" @default.
- W4376274906 cites W1798012002 @default.
- W4376274906 cites W1899095474 @default.
- W4376274906 cites W1965813509 @default.
- W4376274906 cites W1967270924 @default.
- W4376274906 cites W2019269134 @default.
- W4376274906 cites W2025672294 @default.
- W4376274906 cites W2028543411 @default.
- W4376274906 cites W2104254580 @default.
- W4376274906 cites W2107208293 @default.
- W4376274906 cites W2109298880 @default.
- W4376274906 cites W2145142940 @default.
- W4376274906 cites W2277734620 @default.
- W4376274906 cites W2414176003 @default.
- W4376274906 cites W2419151490 @default.
- W4376274906 cites W2429159846 @default.
- W4376274906 cites W2609800424 @default.
- W4376274906 cites W2621934018 @default.
- W4376274906 cites W2792580051 @default.
- W4376274906 cites W2793138562 @default.
- W4376274906 cites W2796493184 @default.
- W4376274906 cites W2800659616 @default.
- W4376274906 cites W2889365262 @default.
- W4376274906 cites W2965584378 @default.
- W4376274906 cites W2976801209 @default.
- W4376274906 cites W2990592352 @default.
- W4376274906 cites W2995158846 @default.
- W4376274906 cites W3010201322 @default.
- W4376274906 cites W3011394045 @default.
- W4376274906 cites W3043319275 @default.
- W4376274906 cites W3091175966 @default.
- W4376274906 cites W3106893457 @default.
- W4376274906 cites W3120914593 @default.
- W4376274906 cites W3124503483 @default.
- W4376274906 cites W3134379672 @default.
- W4376274906 cites W3137648776 @default.
- W4376274906 cites W3138966945 @default.
- W4376274906 cites W3157915662 @default.
- W4376274906 cites W3159724082 @default.
- W4376274906 cites W3162851668 @default.
- W4376274906 cites W3170377228 @default.
- W4376274906 cites W3189065355 @default.
- W4376274906 cites W4200591611 @default.
- W4376274906 cites W4213264012 @default.
- W4376274906 cites W4313988781 @default.
- W4376274906 doi "https://doi.org/10.3390/ijms24108694" @default.
- W4376274906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37240036" @default.
- W4376274906 hasPublicationYear "2023" @default.
- W4376274906 type Work @default.
- W4376274906 citedByCount "1" @default.
- W4376274906 countsByYear W43762749062023 @default.
- W4376274906 crossrefType "journal-article" @default.
- W4376274906 hasAuthorship W4376274906A5016438972 @default.
- W4376274906 hasAuthorship W4376274906A5021984184 @default.
- W4376274906 hasAuthorship W4376274906A5028933668 @default.
- W4376274906 hasAuthorship W4376274906A5030849116 @default.
- W4376274906 hasAuthorship W4376274906A5044544424 @default.
- W4376274906 hasAuthorship W4376274906A5061250894 @default.
- W4376274906 hasAuthorship W4376274906A5061664204 @default.
- W4376274906 hasAuthorship W4376274906A5069952203 @default.
- W4376274906 hasAuthorship W4376274906A5075877965 @default.
- W4376274906 hasBestOaLocation W43762749061 @default.
- W4376274906 hasConcept C104317684 @default.
- W4376274906 hasConcept C126322002 @default.
- W4376274906 hasConcept C141071460 @default.
- W4376274906 hasConcept C142724271 @default.
- W4376274906 hasConcept C145059251 @default.
- W4376274906 hasConcept C150903083 @default.
- W4376274906 hasConcept C16930146 @default.
- W4376274906 hasConcept C171089720 @default.
- W4376274906 hasConcept C17991360 @default.
- W4376274906 hasConcept C185592680 @default.
- W4376274906 hasConcept C198826908 @default.
- W4376274906 hasConcept C203014093 @default.
- W4376274906 hasConcept C20518536 @default.
- W4376274906 hasConcept C207001950 @default.
- W4376274906 hasConcept C2776541429 @default.
- W4376274906 hasConcept C2777251235 @default.
- W4376274906 hasConcept C2777556957 @default.
- W4376274906 hasConcept C2778690821 @default.
- W4376274906 hasConcept C2780269544 @default.
- W4376274906 hasConcept C2781261824 @default.
- W4376274906 hasConcept C502942594 @default.
- W4376274906 hasConcept C55493867 @default.
- W4376274906 hasConcept C71924100 @default.