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- W4376275005 abstract "Abstract Static magnetic field (SMF) therapy has been proven effective in various tissue repairs. Diamagnetic anisotropy may induce SMF to impact biological macromolecules. The formation of new blood vessels, or angiogenesis, is essential for many pathophysiological processes, including development, reproduction, tumour growth, and metastasis. Inhibiting angiogenesis is one of the key objectives in the fight against cancer and other diseases. The mechanism underlying SMF-mediated regulation of angiogenesis and fibroblast migration is still unclear. Thus, the goal is to investigate the influence of SMF on avian angiogenesis using the chorioallantois membrane (CAM) experiment and murine fibroblast migration. Gallus gallus fertilised eggs were placed in an incubator from day 3 to 7 to the isocentre of the Neodymium Magnet block (30 milli Tesla (mT); North-pole or upward; SMF + ) was exposed, and control eggs were placed in a separate incubator (SMF - ). On day 7, the angiogenesis or neovascularisation vascular parameters were analysed using a stereoscope and AngioTool. SMF + stimulation showed a statistically significant decrease in vascular parameters compared to the control. Additionally, the effect of SMF + on murine fibroblast cell viability, ROS, and migration was explored. Compared to unexposed cells, SMF + stimulation showed a statistically significant decrease in cellular ROS production and migration after 24 hours without a change in cell viability. These findings imply that SMF could be an effective adjuvant therapy for limiting or preventing excessive ROS, angiogenesis, and fibroblast migration; this effect may be utilised to treat cancer, diabetic retinopathy, and other disorders that entail excessive pathological angiogenesis." @default.
- W4376275005 created "2023-05-13" @default.
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- W4376275005 date "2023-05-12" @default.
- W4376275005 modified "2023-09-30" @default.
- W4376275005 title "Impact of Static Magnetic Field on In Ovo Angiogenesis and In Vitro Cell Migration" @default.
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- W4376275005 doi "https://doi.org/10.21203/rs.3.rs-2912162/v1" @default.
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