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• W4376275057 abstract "Abstract Adenosine deaminase family acting on RNA 1 (ADAR1) expression was examined to determine its correlation with endometriosis. The biological functions and inhibitory effects of ADAR1 knockdown were investigated in the EMC100, EMC214, and EPC-1 cell lines. ADAR1 was examined in patients with and without endometriosis using reverse transcription polymerase chain reaction (RT-PCR). The apoptotic expression of ADAR1 small interfering RNA (siRNA) was confirmed using flow cytometry. The biological functions and inhibitory effects of ADAR1 knockdown were investigated using RT-PCR in immortalized human uterine endometrial cell lines. ADAR1 expression was significantly higher in patients with endometriosis than in those without (P = 0.044). The proportions of viable cells decreased to 60.8%, 61.9%, and 72.9% (mock) and 58.9%, 40.2% and 59.1% (control) of the control cell viability at 48 hours after transient transfection of the ADAR1 siRNA into EMC100, EMC214, and EPC-1 cell lines. ADAR1 knockdown led to apoptosis through MDA-5, RIG-I, PKR, IRF3, IRF7, Caspase3, Caspase7, and Caspase8 expression. ADAR1 could be a potential therapeutic target in endometriosis." @default.
• W4376275057 created "2023-05-13" @default.
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• W4376275057 date "2023-05-12" @default.
• W4376275057 modified "2023-10-17" @default.
• W4376275057 title "Adenosine deaminase family acting on RNA 1 may be a de novo target on endometriosis" @default.
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• W4376275057 doi "https://doi.org/10.21203/rs.3.rs-2861746/v1" @default.
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