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- W4376278511 abstract "Neovascularization is the result of an imbalance between pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is one of the most important proangiogenic factors and its expression is enhanced in the ischemic retina. The study and introduction of VEGF inhibitors into the combined surgical treatment of neovascular glaucoma (NVG) in recent years have been of increasing interest to ophthalmologists. The review article presents an analysis of Russian and foreign literature on the use of anti-VEGF drugs (bevacizumab, ranibizumab, aflibercept and conbercept) in surgery of NVG, which are used «off-label» for this disease. The efficacy is evaluated and various methods of their administration are presented, as well as possible complications. The authors conclude that the most successful strategy in combined treatment of NVG is the use of antiangiogenic drugs, since in the vast majority of cases it allows to achieve the rapid disappearance or, at least, a significant regression of the iris rubeosis and reduction of hemorrhagic complications, which significantly improves the efficacy of subsequent surgical treatment of NVG. Keywords: neovascularization, anti-VEGF drugs, surgical treatment of neovascular glaucoma, prevention of hemorrhagic complications, improving the efficacy of surgical treatment" @default.
- W4376278511 created "2023-05-13" @default.
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- W4376278511 date "2023-05-03" @default.
- W4376278511 modified "2023-10-01" @default.
- W4376278511 title "The use of angiogenesis blockers in the combined treatment of neovascular glaucoma" @default.
- W4376278511 doi "https://doi.org/10.25276/2410-1257-2023-1-43-48" @default.
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