FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376278723> ?p ?o ?g. }

• W4376278723 endingPage "790" @default.
• W4376278723 startingPage "790" @default.
• W4376278723 abstract "Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels in the peripheral circulatory system of Parkinson's disease (PD) patients. TMAO is a gut microbiota metabolite that can cross the blood-brain barrier and is strongly related to neuroinflammation. Neuroinflammation is one of the pathological drivers of PD. Herein, we investigated the effect of TMAO on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model mice. TMAO pretreatment was given by adding 1.5% (w/v) TMAO to the drinking water of the mice for 21 days; then, the mice were administered MPTP (20 mg/kg, i.p.) four times a day to construct an acute PD model. Their serum TMAO concentrations, motor function, dopaminergic network integrity, and neuroinflammation were then assayed. The results showed that TMAO partly aggravated the motor dysfunction of the PD mice. Although TMAO had no effect on the dopaminergic neurons, TH protein content, and striatal DA level in the PD mice, it significantly reduced the striatal 5-HT levels and aggravated the metabolism of DA and 5-HT. Meanwhile, TMAO significantly activated glial cells in the striatum and the hippocampi of the PD mice and promoted the release of inflammatory cytokines in the hippocampus. In summary, higher-circulating TMAO had adverse effects on the motor capacity, striatum neurotransmitters, and striatal and hippocampal neuroinflammation in PD mice." @default.
• W4376278723 created "2023-05-13" @default.
• W4376278723 creator A5013243562 @default.
• W4376278723 creator A5019287377 @default.
• W4376278723 creator A5037746426 @default.
• W4376278723 creator A5044785252 @default.
• W4376278723 creator A5044787100 @default.
• W4376278723 creator A5079882589 @default.
• W4376278723 creator A5080802786 @default.
• W4376278723 creator A5088441138 @default.
• W4376278723 date "2023-05-12" @default.
• W4376278723 modified "2023-10-14" @default.
• W4376278723 title "Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease" @default.
• W4376278723 cites W1617526274 @default.
• W4376278723 cites W1977070664 @default.
• W4376278723 cites W2000631088 @default.
• W4376278723 cites W2022911097 @default.
• W4376278723 cites W2038205971 @default.
• W4376278723 cites W2112946345 @default.
• W4376278723 cites W2492949411 @default.
• W4376278723 cites W2558041282 @default.
• W4376278723 cites W2766936425 @default.
• W4376278723 cites W2784568242 @default.
• W4376278723 cites W2790863554 @default.
• W4376278723 cites W2799984449 @default.
• W4376278723 cites W2905287236 @default.
• W4376278723 cites W2918662515 @default.
• W4376278723 cites W2937022773 @default.
• W4376278723 cites W2972032017 @default.
• W4376278723 cites W2984529289 @default.
• W4376278723 cites W2987002293 @default.
• W4376278723 cites W2989097265 @default.
• W4376278723 cites W3004337936 @default.
• W4376278723 cites W3077754188 @default.
• W4376278723 cites W3082205445 @default.
• W4376278723 cites W3082564026 @default.
• W4376278723 cites W3107395714 @default.
• W4376278723 cites W3108081585 @default.
• W4376278723 cites W3109685639 @default.
• W4376278723 cites W3126390049 @default.
• W4376278723 cites W3127844969 @default.
• W4376278723 cites W3151147472 @default.
• W4376278723 cites W3164785017 @default.
• W4376278723 cites W3198643512 @default.
• W4376278723 cites W3211876735 @default.
• W4376278723 cites W4210609396 @default.
• W4376278723 cites W4213161733 @default.
• W4376278723 cites W4220946971 @default.
• W4376278723 cites W4241279990 @default.
• W4376278723 cites W4281854361 @default.
• W4376278723 cites W4292641415 @default.
• W4376278723 cites W4294090794 @default.
• W4376278723 cites W4309455544 @default.
• W4376278723 doi "https://doi.org/10.3390/brainsci13050790" @default.
• W4376278723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37239262" @default.
• W4376278723 hasPublicationYear "2023" @default.
• W4376278723 type Work @default.
• W4376278723 citedByCount "0" @default.
• W4376278723 crossrefType "journal-article" @default.
• W4376278723 hasAuthorship W4376278723A5013243562 @default.
• W4376278723 hasAuthorship W4376278723A5019287377 @default.
• W4376278723 hasAuthorship W4376278723A5037746426 @default.
• W4376278723 hasAuthorship W4376278723A5044785252 @default.
• W4376278723 hasAuthorship W4376278723A5044787100 @default.
• W4376278723 hasAuthorship W4376278723A5079882589 @default.
• W4376278723 hasAuthorship W4376278723A5080802786 @default.
• W4376278723 hasAuthorship W4376278723A5088441138 @default.
• W4376278723 hasBestOaLocation W43762787231 @default.
• W4376278723 hasConcept C126322002 @default.
• W4376278723 hasConcept C134018914 @default.
• W4376278723 hasConcept C137183658 @default.
• W4376278723 hasConcept C185592680 @default.
• W4376278723 hasConcept C2776149385 @default.
• W4376278723 hasConcept C2776914184 @default.
• W4376278723 hasConcept C2778674702 @default.
• W4376278723 hasConcept C2779134260 @default.
• W4376278723 hasConcept C2779734285 @default.
• W4376278723 hasConcept C2780062018 @default.
• W4376278723 hasConcept C2780924926 @default.
• W4376278723 hasConcept C513476851 @default.
• W4376278723 hasConcept C55493867 @default.
• W4376278723 hasConcept C71924100 @default.
• W4376278723 hasConcept C87753298 @default.
• W4376278723 hasConcept C98274493 @default.
• W4376278723 hasConceptScore W4376278723C126322002 @default.
• W4376278723 hasConceptScore W4376278723C134018914 @default.
• W4376278723 hasConceptScore W4376278723C137183658 @default.
• W4376278723 hasConceptScore W4376278723C185592680 @default.
• W4376278723 hasConceptScore W4376278723C2776149385 @default.
• W4376278723 hasConceptScore W4376278723C2776914184 @default.
• W4376278723 hasConceptScore W4376278723C2778674702 @default.
• W4376278723 hasConceptScore W4376278723C2779134260 @default.
• W4376278723 hasConceptScore W4376278723C2779734285 @default.
• W4376278723 hasConceptScore W4376278723C2780062018 @default.
• W4376278723 hasConceptScore W4376278723C2780924926 @default.
• W4376278723 hasConceptScore W4376278723C513476851 @default.
• W4376278723 hasConceptScore W4376278723C55493867 @default.
• W4376278723 hasConceptScore W4376278723C71924100 @default.

• next