FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376278987> ?p ?o ?g. }

• W4376278987 endingPage "1082" @default.
• W4376278987 startingPage "1082" @default.
• W4376278987 abstract "Aucubin is an iridoid glycoside that displays various pharmacological actions including antioxidant activity. However, there are few reports available on the neuroprotective effects of aucubin against ischemic brain injury. Thus, the aim of this study was to investigate whether aucubin protected against damage to hippocampal function induced by forebrain ischemia-reperfusion injury (fIRI) in gerbils, and to examine whether aucubin produced neuroprotection in the hippocampus against fIRI and to explore its mechanisms by histopathology, immunohistochemistry, and Western analysis. Gerbils were given intraperitoneal injections of aucubin at doses of 1, 5, and 10 mg/kg, respectively, once a day for seven days before fIRI. As assessed by the passive avoidance test, short-term memory function following fIRI significantly declined, whereas the decline in short-term memory function due to fIRI was ameliorated by pretreatment with 10 mg/kg, but not 1 or 5 mg/kg, of aucubin. Most of the pyramidal cells (principal cells) of the hippocampus died in the Cornu Ammonis 1 (CA1) area four days after fIRI. Treatment with 10 mg/kg, but not 1 or 5 mg/kg, of aucubin protected the pyramidal cells from IRI. The treatment with 10 mg/kg of aucubin significantly reduced IRI-induced superoxide anion production, oxidative DNA damage, and lipid peroxidation in the CA1 pyramidal cells. In addition, the aucubin treatment significantly increased the expressions of superoxide dismutases (SOD1 and SOD2) in the pyramidal cells before and after fIRI. Furthermore, the aucubin treatment significantly enhanced the protein expression levels of neurotrophic factors, such as brain-derived neurotrophic factor and insulin-like growth factor-I, in the hippocampal CA1 area before and after IRI. Collectively, in this experiment, pretreatment with aucubin protected CA1 pyramidal cells from forebrain IRI by attenuating oxidative stress and increasing neurotrophic factors. Thus, pretreatment with aucubin can be a promising candidate for preventing brain IRI." @default.
• W4376278987 created "2023-05-13" @default.
• W4376278987 creator A5009549868 @default.
• W4376278987 creator A5010808931 @default.
• W4376278987 creator A5013587097 @default.
• W4376278987 creator A5037868500 @default.
• W4376278987 creator A5052748288 @default.
• W4376278987 creator A5053801833 @default.
• W4376278987 creator A5071539415 @default.
• W4376278987 creator A5074722195 @default.
• W4376278987 creator A5075174454 @default.
• W4376278987 creator A5078647101 @default.
• W4376278987 date "2023-05-11" @default.
• W4376278987 modified "2023-10-16" @default.
• W4376278987 title "Aucubin Exerts Neuroprotection against Forebrain Ischemia and Reperfusion Injury in Gerbils through Antioxidative and Neurotrophic Effects" @default.
• W4376278987 cites W1509252858 @default.
• W4376278987 cites W1527017265 @default.
• W4376278987 cites W1830865753 @default.
• W4376278987 cites W1976915575 @default.
• W4376278987 cites W1984511173 @default.
• W4376278987 cites W2009898348 @default.
• W4376278987 cites W2020622209 @default.
• W4376278987 cites W2026706584 @default.
• W4376278987 cites W2031773044 @default.
• W4376278987 cites W2042177793 @default.
• W4376278987 cites W2046879748 @default.
• W4376278987 cites W2046913316 @default.
• W4376278987 cites W2060746511 @default.
• W4376278987 cites W2067914358 @default.
• W4376278987 cites W2070276449 @default.
• W4376278987 cites W2080279037 @default.
• W4376278987 cites W2087265348 @default.
• W4376278987 cites W2117104323 @default.
• W4376278987 cites W2118414643 @default.
• W4376278987 cites W2170806182 @default.
• W4376278987 cites W2173474974 @default.
• W4376278987 cites W2300776102 @default.
• W4376278987 cites W2395947857 @default.
• W4376278987 cites W2515285711 @default.
• W4376278987 cites W2566356165 @default.
• W4376278987 cites W2781417551 @default.
• W4376278987 cites W2802537586 @default.
• W4376278987 cites W2802826842 @default.
• W4376278987 cites W2803630466 @default.
• W4376278987 cites W2810858102 @default.
• W4376278987 cites W2821222121 @default.
• W4376278987 cites W2942589268 @default.
• W4376278987 cites W2974045693 @default.
• W4376278987 cites W3002833806 @default.
• W4376278987 cites W3010589304 @default.
• W4376278987 cites W3016724127 @default.
• W4376278987 cites W3034513491 @default.
• W4376278987 cites W3047052056 @default.
• W4376278987 cites W3049437820 @default.
• W4376278987 cites W3084137375 @default.
• W4376278987 cites W3154409653 @default.
• W4376278987 cites W3155511665 @default.
• W4376278987 cites W3156307181 @default.
• W4376278987 cites W3163794639 @default.
• W4376278987 cites W3185875141 @default.
• W4376278987 doi "https://doi.org/10.3390/antiox12051082" @default.
• W4376278987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37237948" @default.
• W4376278987 hasPublicationYear "2023" @default.
• W4376278987 type Work @default.
• W4376278987 citedByCount "0" @default.
• W4376278987 crossrefType "journal-article" @default.
• W4376278987 hasAuthorship W4376278987A5009549868 @default.
• W4376278987 hasAuthorship W4376278987A5010808931 @default.
• W4376278987 hasAuthorship W4376278987A5013587097 @default.
• W4376278987 hasAuthorship W4376278987A5037868500 @default.
• W4376278987 hasAuthorship W4376278987A5052748288 @default.
• W4376278987 hasAuthorship W4376278987A5053801833 @default.
• W4376278987 hasAuthorship W4376278987A5071539415 @default.
• W4376278987 hasAuthorship W4376278987A5074722195 @default.
• W4376278987 hasAuthorship W4376278987A5075174454 @default.
• W4376278987 hasAuthorship W4376278987A5078647101 @default.
• W4376278987 hasBestOaLocation W43762789871 @default.
• W4376278987 hasConcept C126322002 @default.
• W4376278987 hasConcept C134018914 @default.
• W4376278987 hasConcept C160539049 @default.
• W4376278987 hasConcept C170493617 @default.
• W4376278987 hasConcept C178790620 @default.
• W4376278987 hasConcept C185592680 @default.
• W4376278987 hasConcept C194671627 @default.
• W4376278987 hasConcept C25498285 @default.
• W4376278987 hasConcept C2778413156 @default.
• W4376278987 hasConcept C2778790584 @default.
• W4376278987 hasConcept C2779632648 @default.
• W4376278987 hasConcept C42219234 @default.
• W4376278987 hasConcept C71924100 @default.
• W4376278987 hasConcept C98274493 @default.
• W4376278987 hasConceptScore W4376278987C126322002 @default.
• W4376278987 hasConceptScore W4376278987C134018914 @default.
• W4376278987 hasConceptScore W4376278987C160539049 @default.
• W4376278987 hasConceptScore W4376278987C170493617 @default.
• W4376278987 hasConceptScore W4376278987C178790620 @default.
• W4376278987 hasConceptScore W4376278987C185592680 @default.
• W4376278987 hasConceptScore W4376278987C194671627 @default.

• next