Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376279311> ?p ?o ?g. }
- W4376279311 abstract "Background Sex differences in the susceptibility of sarcoidosis are unknown. The study aims to identify sex-dependent genetic variations in two clinical sarcoidosis phenotypes: Löfgren’s syndrome (LS) and non-Löfgren’s syndrome (non-LS). Methods A meta-analysis of genome-wide association studies was conducted on Europeans and African Americans, totaling 10,103 individuals from three population-based cohorts, Sweden ( n = 3,843), Germany ( n = 3,342), and the United States ( n = 2,918), followed by an SNP lookup in the UK Biobank (UKB, n = 387,945). A genome-wide association study based on Immunochip data consisting of 141,000 single nucleotide polymorphisms (SNPs) was conducted in the sex groups. The association test was based on logistic regression using the additive model in LS and non-LS sex groups independently. Additionally, gene-based analysis, gene expression, expression quantitative trait loci (eQTL) mapping, and pathway analysis were performed to discover functionally relevant mechanisms related to sarcoidosis and biological sex. Results We identified sex-dependent genetic variations in LS and non-LS sex groups. Genetic findings in LS sex groups were explicitly located in the extended Major Histocompatibility Complex (xMHC). In non-LS, genetic differences in the sex groups were primarily located in the MHC class II subregion and ANXA11 . Gene-based analysis and eQTL enrichment revealed distinct sex-specific gene expression patterns in various tissues and immune cell types. In LS sex groups, a pathway map related to antigen presentation machinery by IFN-gamma. In non-LS, pathway maps related to immune response lectin-induced complement pathway in males and related to maturation and migration of dendritic cells in skin sensitization in females were identified. Conclusion Our findings provide new evidence for a sex bias underlying sarcoidosis genetic architecture, particularly in clinical phenotypes LS and non-LS. Biological sex likely plays a role in disease mechanisms in sarcoidosis." @default.
- W4376279311 created "2023-05-13" @default.
- W4376279311 creator A5000843678 @default.
- W4376279311 creator A5002131258 @default.
- W4376279311 creator A5007172317 @default.
- W4376279311 creator A5008925868 @default.
- W4376279311 creator A5012331187 @default.
- W4376279311 creator A5014957864 @default.
- W4376279311 creator A5023482754 @default.
- W4376279311 creator A5026930111 @default.
- W4376279311 creator A5036270456 @default.
- W4376279311 creator A5037083310 @default.
- W4376279311 creator A5040774618 @default.
- W4376279311 creator A5049958633 @default.
- W4376279311 creator A5082032036 @default.
- W4376279311 creator A5087780392 @default.
- W4376279311 creator A5088656232 @default.
- W4376279311 date "2023-05-11" @default.
- W4376279311 modified "2023-10-18" @default.
- W4376279311 title "Sex differences in the genetics of sarcoidosis across European and African ancestry populations" @default.
- W4376279311 cites W1600162161 @default.
- W4376279311 cites W1962078396 @default.
- W4376279311 cites W1976464271 @default.
- W4376279311 cites W1984636340 @default.
- W4376279311 cites W1984722293 @default.
- W4376279311 cites W1984926875 @default.
- W4376279311 cites W1993499647 @default.
- W4376279311 cites W1994662654 @default.
- W4376279311 cites W2013221211 @default.
- W4376279311 cites W2025408360 @default.
- W4376279311 cites W2029857463 @default.
- W4376279311 cites W2030320984 @default.
- W4376279311 cites W2035451872 @default.
- W4376279311 cites W2037682100 @default.
- W4376279311 cites W2044833878 @default.
- W4376279311 cites W2047366932 @default.
- W4376279311 cites W2051314902 @default.
- W4376279311 cites W2060358031 @default.
- W4376279311 cites W2060661010 @default.
- W4376279311 cites W2061191029 @default.
- W4376279311 cites W206873995 @default.
- W4376279311 cites W2082704080 @default.
- W4376279311 cites W2083296472 @default.
- W4376279311 cites W2090929056 @default.
- W4376279311 cites W2097605211 @default.
- W4376279311 cites W2099085143 @default.
- W4376279311 cites W2111644303 @default.
- W4376279311 cites W2112632706 @default.
- W4376279311 cites W2116428200 @default.
- W4376279311 cites W2127663060 @default.
- W4376279311 cites W2129472769 @default.
- W4376279311 cites W2131249054 @default.
- W4376279311 cites W2132402446 @default.
- W4376279311 cites W2132576596 @default.
- W4376279311 cites W2132975663 @default.
- W4376279311 cites W2133520037 @default.
- W4376279311 cites W2135403800 @default.
- W4376279311 cites W2139168999 @default.
- W4376279311 cites W2142577289 @default.
- W4376279311 cites W2142907734 @default.
- W4376279311 cites W2144382874 @default.
- W4376279311 cites W2145323940 @default.
- W4376279311 cites W2148336270 @default.
- W4376279311 cites W2157752701 @default.
- W4376279311 cites W2159221815 @default.
- W4376279311 cites W2161633633 @default.
- W4376279311 cites W2167405859 @default.
- W4376279311 cites W2190867064 @default.
- W4376279311 cites W2340549150 @default.
- W4376279311 cites W2488020095 @default.
- W4376279311 cites W2517126243 @default.
- W4376279311 cites W2528115611 @default.
- W4376279311 cites W2586329328 @default.
- W4376279311 cites W2740557473 @default.
- W4376279311 cites W2765710896 @default.
- W4376279311 cites W2766660067 @default.
- W4376279311 cites W2770092353 @default.
- W4376279311 cites W2782484253 @default.
- W4376279311 cites W2787559752 @default.
- W4376279311 cites W2802580172 @default.
- W4376279311 cites W2802731336 @default.
- W4376279311 cites W2867747856 @default.
- W4376279311 cites W2935788658 @default.
- W4376279311 cites W2963436689 @default.
- W4376279311 cites W2999794673 @default.
- W4376279311 cites W3000187202 @default.
- W4376279311 cites W3012366159 @default.
- W4376279311 cites W3020796533 @default.
- W4376279311 cites W3025902189 @default.
- W4376279311 cites W3045186293 @default.
- W4376279311 cites W3180628262 @default.
- W4376279311 cites W3191807378 @default.
- W4376279311 cites W3197364483 @default.
- W4376279311 cites W3199990935 @default.
- W4376279311 cites W3216049172 @default.
- W4376279311 cites W4210995779 @default.
- W4376279311 cites W4211032738 @default.
- W4376279311 cites W4211150982 @default.
- W4376279311 cites W4224980660 @default.
- W4376279311 cites W4244376495 @default.