Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376280122> ?p ?o ?g. }
- W4376280122 endingPage "855" @default.
- W4376280122 startingPage "843" @default.
- W4376280122 abstract "Solubility of the drug is an important property of the drug as it affects the release, absorption, dissolution rate and ultimately bioavailability of the drug. Hence, the poorly aqueous soluble drug, need to be processed, to enhance its solubility and dissolution. The Biopharmaceutical System of Classification (BCS) II drugs are poorly soluble and have high permeability. Though their good ability to permeate through the membrane make them clinically useful but the problem associated with the solubility restrict their clinical use. Therefore, there is need to improve the solubility of such drug molecules to get effective pharmacological action. Itraconazole (ITZ) is an antifungal agent used in the treatment of fungal infections having poor aqueous solubility as belonging to BCS class II. The present study was aim to enhance the solubility of ITZ by solid dispersion and co-crystallization techniques. Investigation of simultaneous effect of media composition on drug dissolution was also the objective of this work. The ITZ-SD and ITZ-CCs were prepared from ITZ and other excipients like PEG 4000, oxalic acid, fumaric and malic acid by solvent evaporation, kneading technique, slurry conversion and solvent drop grinding methods. The prepared ITZ-SD, ITZ-OA-CCs, ITZ-FA-CCs and ITZ-MA-CCs were evaluated for FTIR, DSC, PXRD, % yield, micromeritic properties. The optimized ITZ-SD and ITZ-CCs were used to compress a tablet and subject to post-compression parameters. The results of FTIR and DSC showed the absence of interaction between the drug and excipients. The PXRD pattern demonstrated the formation of crystalline structures with 6 folds increased in solubility during saturation solubility analysis. In vitro dissolution was carried out in dissolution media with different pH which shows the maximum release from ITZ-SD and ITZ-CCs in pH 6.8. This also revealed the highly pH dependent solubility and dissolution behavior of the weakly basic BCS class II drug (ITZ) with pKa value of 3.7. The overall results in this study indicated the potential of solid dispersion and co-crystals for enhancement of solubility of the poorly water-soluble drugs." @default.
- W4376280122 created "2023-05-13" @default.
- W4376280122 creator A5022328668 @default.
- W4376280122 creator A5039192690 @default.
- W4376280122 creator A5076737288 @default.
- W4376280122 creator A5076913759 @default.
- W4376280122 creator A5083998812 @default.
- W4376280122 creator A5086039900 @default.
- W4376280122 creator A5088437563 @default.
- W4376280122 creator A5091931373 @default.
- W4376280122 creator A5091931374 @default.
- W4376280122 creator A5091931375 @default.
- W4376280122 creator A5088604082 @default.
- W4376280122 date "2023-09-01" @default.
- W4376280122 modified "2023-10-14" @default.
- W4376280122 title "Comparative assessment of solubility enhancement of itroconazole by solid dispersion and co-crystallization technique: Investigation of simultaneous effect of media composition on drug dissolution" @default.
- W4376280122 cites W1964372069 @default.
- W4376280122 cites W1968890988 @default.
- W4376280122 cites W1971295150 @default.
- W4376280122 cites W1976544366 @default.
- W4376280122 cites W1981460456 @default.
- W4376280122 cites W1986703901 @default.
- W4376280122 cites W1998580244 @default.
- W4376280122 cites W1999711931 @default.
- W4376280122 cites W2016283290 @default.
- W4376280122 cites W2025979844 @default.
- W4376280122 cites W2028837722 @default.
- W4376280122 cites W2044998480 @default.
- W4376280122 cites W2061381493 @default.
- W4376280122 cites W2061991556 @default.
- W4376280122 cites W2088828170 @default.
- W4376280122 cites W2139291218 @default.
- W4376280122 cites W2174293826 @default.
- W4376280122 cites W2175039963 @default.
- W4376280122 cites W2181631481 @default.
- W4376280122 cites W2311627381 @default.
- W4376280122 cites W2740603322 @default.
- W4376280122 cites W2751868938 @default.
- W4376280122 cites W2767187922 @default.
- W4376280122 cites W2770454322 @default.
- W4376280122 cites W2779263281 @default.
- W4376280122 cites W2794796903 @default.
- W4376280122 cites W2800764235 @default.
- W4376280122 cites W2884116537 @default.
- W4376280122 cites W2903753184 @default.
- W4376280122 cites W2942754201 @default.
- W4376280122 cites W2994216830 @default.
- W4376280122 cites W3003237512 @default.
- W4376280122 cites W3115593892 @default.
- W4376280122 cites W329485008 @default.
- W4376280122 cites W4221058693 @default.
- W4376280122 cites W4226488194 @default.
- W4376280122 cites W4281289199 @default.
- W4376280122 cites W4283746915 @default.
- W4376280122 cites W4308506804 @default.
- W4376280122 cites W4308922462 @default.
- W4376280122 cites W4309860437 @default.
- W4376280122 doi "https://doi.org/10.1016/j.pharma.2023.05.004" @default.
- W4376280122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37182590" @default.
- W4376280122 hasPublicationYear "2023" @default.
- W4376280122 type Work @default.
- W4376280122 citedByCount "1" @default.
- W4376280122 crossrefType "journal-article" @default.
- W4376280122 hasAuthorship W4376280122A5022328668 @default.
- W4376280122 hasAuthorship W4376280122A5039192690 @default.
- W4376280122 hasAuthorship W4376280122A5076737288 @default.
- W4376280122 hasAuthorship W4376280122A5076913759 @default.
- W4376280122 hasAuthorship W4376280122A5083998812 @default.
- W4376280122 hasAuthorship W4376280122A5086039900 @default.
- W4376280122 hasAuthorship W4376280122A5088437563 @default.
- W4376280122 hasAuthorship W4376280122A5088604082 @default.
- W4376280122 hasAuthorship W4376280122A5091931373 @default.
- W4376280122 hasAuthorship W4376280122A5091931374 @default.
- W4376280122 hasAuthorship W4376280122A5091931375 @default.
- W4376280122 hasConcept C100687433 @default.
- W4376280122 hasConcept C112887158 @default.
- W4376280122 hasConcept C127413603 @default.
- W4376280122 hasConcept C13965031 @default.
- W4376280122 hasConcept C155574463 @default.
- W4376280122 hasConcept C178790620 @default.
- W4376280122 hasConcept C181389837 @default.
- W4376280122 hasConcept C185592680 @default.
- W4376280122 hasConcept C192562407 @default.
- W4376280122 hasConcept C203036418 @default.
- W4376280122 hasConcept C2780471494 @default.
- W4376280122 hasConcept C32909587 @default.
- W4376280122 hasConcept C42360764 @default.
- W4376280122 hasConcept C43617362 @default.
- W4376280122 hasConcept C71924100 @default.
- W4376280122 hasConcept C88380143 @default.
- W4376280122 hasConcept C98274493 @default.
- W4376280122 hasConceptScore W4376280122C100687433 @default.
- W4376280122 hasConceptScore W4376280122C112887158 @default.
- W4376280122 hasConceptScore W4376280122C127413603 @default.
- W4376280122 hasConceptScore W4376280122C13965031 @default.
- W4376280122 hasConceptScore W4376280122C155574463 @default.
- W4376280122 hasConceptScore W4376280122C178790620 @default.
- W4376280122 hasConceptScore W4376280122C181389837 @default.