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- W4376280166 abstract "Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of other solid tumors resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding nucleoporin 210, NUP210, when comparing tumor tissue from the human cervix to the tissue of origin. NUP210 mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of NUP210 in tumors of the cervix was correlated with recurrence-free survival in patients with cervical cancer. NUP210 expression changes may be important for the initiation or progression of cancer of the cervix in humans." @default.
- W4376280166 created "2023-05-13" @default.
- W4376280166 creator A5024900493 @default.
- W4376280166 date "2023-05-11" @default.
- W4376280166 modified "2023-10-01" @default.
- W4376280166 title "Differential expression of NUP210 in cancer of the cervix." @default.
- W4376280166 doi "https://doi.org/10.31219/osf.io/k63rd" @default.
- W4376280166 hasPublicationYear "2023" @default.
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