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- W4376286391 abstract "Transfer RNA (tRNA) plays a central role in translation by functioning as a biological link between messenger RNA (mRNA) and proteins. One prominent feature of the tRNA molecule is its heavily modified status, which greatly affects its biogenesis and function. Modifications within the anticodon loop are crucial for translation efficiency and accuracy, whereas other modifications in the body region affect tRNA structure and stability. Recent research has revealed that these diverse modifications are critical regulators of gene expression. They are involved in many important physiological and pathological processes, including cancers. In this review we focus on six different tRNA modifications to delineate their functions and mechanisms in tumorigenesis and tumor progression, providing insights into their clinical potential as biomarkers and therapeutic targets." @default.
- W4376286391 created "2023-05-13" @default.
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- W4376286391 date "2023-05-01" @default.
- W4376286391 modified "2023-10-17" @default.
- W4376286391 title "tRNA modifications: insights into their role in human cancers" @default.
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- W4376286391 doi "https://doi.org/10.1016/j.tcb.2023.04.002" @default.
- W4376286391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37179136" @default.
- W4376286391 hasPublicationYear "2023" @default.
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