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- W4376453319 endingPage "90" @default.
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- W4376453319 abstract "Developing the most efficient strategy for the purification of a (recombinant) protein especially at large scale remains a challenge. A typical problem of the downstream process of mammalian cell products is, for instance, the early capture of the highly diluted product from the complex process stream. Affinity precipitation has been suggested in this context. The technique is known for over 20 years, but has recently received more attention due to the development of new materials for its implementation, but also because it seems ideally suited to specific product capture at large scale. The present review gives a comprehensive overview over this technique. Besides an introduction to the basic principle and a brief summary of the historical development, the main focus is on the current state-of-art of the technique, the available materials, important recent applications, as well as process design strategies and operating procedures. Special consideration is given to affinity precipitation for product recovery at large scale." @default.
- W4376453319 created "2023-05-14" @default.
- W4376453319 creator A5030045839 @default.
- W4376453319 creator A5041398258 @default.
- W4376453319 date "2003-06-01" @default.
- W4376453319 modified "2023-10-17" @default.
- W4376453319 title "Protein purification by affinity precipitation" @default.
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- W4376453319 doi "https://doi.org/10.1016/s1570-0232(03)00081-3" @default.
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