Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376504313> ?p ?o ?g. }
- W4376504313 abstract "Abstract The common pathogenesis of Alzheimer’s disease (AD) and Parkinson’s disease (PD) has been supported by biochemical, genetic and molecular evidence. Mitochondrial dysfunction is considered to be the common pathology in early AD and PD. The physiological regulation of APP and α-synuclein on mitochondria remains unclear, let alone whether they share common regulatory mechanisms affecting the development of neurodegenerative diseases. By studying gene knockout rats, the commonality of physiological APP and α-synuclein in maintaining mitochondrial function through calcium homeostasis regulation was revealed, which was critical in inhibiting hippocampal degeneration in young rats. APP and α-synuclein both control hippocampal mitochondrial calcium intake and outflow. In the mitochondrial calcium influx regulation, APP and α-synuclein are located on the mitochondrial-associated endoplasmic reticulum membrane (MAM) and converge to regulate the IP 3 R1-Grp75-VDAC2 axis. Mitochondrial calcium outflow is redundantly promoted by both α-synuclein and APP. Loss of APP or SNCA leads to mitochondrial calcium overload, thus enhancing aerobic respiration and ER stress, and ultimately causing excessive apoptosis in the hippocampus and spatial memory impairment in young rats. Based on this study, we believe that the physiological function impairment of APP and SNCA is the early core pathology to induce mitochondrial dysfunction at the early stage of AD and PD, while the IP 3 R1-Grp75-VDAC2 axis might be the common drug target of these two diseases." @default.
- W4376504313 created "2023-05-15" @default.
- W4376504313 creator A5007588252 @default.
- W4376504313 creator A5014426597 @default.
- W4376504313 creator A5032033345 @default.
- W4376504313 creator A5040104075 @default.
- W4376504313 creator A5047310100 @default.
- W4376504313 creator A5051788626 @default.
- W4376504313 creator A5058254184 @default.
- W4376504313 creator A5059228473 @default.
- W4376504313 creator A5077288544 @default.
- W4376504313 creator A5086360069 @default.
- W4376504313 creator A5090429810 @default.
- W4376504313 creator A5091941388 @default.
- W4376504313 date "2023-05-13" @default.
- W4376504313 modified "2023-10-18" @default.
- W4376504313 title "Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats" @default.
- W4376504313 cites W16196038 @default.
- W4376504313 cites W1797318377 @default.
- W4376504313 cites W1824822050 @default.
- W4376504313 cites W1934528477 @default.
- W4376504313 cites W1970436894 @default.
- W4376504313 cites W1973752139 @default.
- W4376504313 cites W1975617209 @default.
- W4376504313 cites W1978582104 @default.
- W4376504313 cites W1981645566 @default.
- W4376504313 cites W1986996580 @default.
- W4376504313 cites W1994580609 @default.
- W4376504313 cites W2005641666 @default.
- W4376504313 cites W2008748100 @default.
- W4376504313 cites W2017406246 @default.
- W4376504313 cites W2027783468 @default.
- W4376504313 cites W2038346401 @default.
- W4376504313 cites W2041622179 @default.
- W4376504313 cites W2052622892 @default.
- W4376504313 cites W2058847849 @default.
- W4376504313 cites W2058866756 @default.
- W4376504313 cites W2058888442 @default.
- W4376504313 cites W2076241970 @default.
- W4376504313 cites W2082315075 @default.
- W4376504313 cites W2091341678 @default.
- W4376504313 cites W2094999489 @default.
- W4376504313 cites W2096579721 @default.
- W4376504313 cites W2098548022 @default.
- W4376504313 cites W2135160983 @default.
- W4376504313 cites W2135466257 @default.
- W4376504313 cites W2146403365 @default.
- W4376504313 cites W2157870562 @default.
- W4376504313 cites W2166432730 @default.
- W4376504313 cites W2170398463 @default.
- W4376504313 cites W2399812166 @default.
- W4376504313 cites W2402118151 @default.
- W4376504313 cites W2417395660 @default.
- W4376504313 cites W2492582783 @default.
- W4376504313 cites W2529946706 @default.
- W4376504313 cites W2558424111 @default.
- W4376504313 cites W2599239219 @default.
- W4376504313 cites W2613365825 @default.
- W4376504313 cites W2760938608 @default.
- W4376504313 cites W2898534233 @default.
- W4376504313 cites W2908268700 @default.
- W4376504313 cites W2914099347 @default.
- W4376504313 cites W2950980285 @default.
- W4376504313 cites W2952095672 @default.
- W4376504313 cites W3027900078 @default.
- W4376504313 cites W3092964313 @default.
- W4376504313 cites W3126624608 @default.
- W4376504313 cites W4317745691 @default.
- W4376504313 cites W2045781262 @default.
- W4376504313 doi "https://doi.org/10.1038/s41419-023-05846-5" @default.
- W4376504313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37179386" @default.
- W4376504313 hasPublicationYear "2023" @default.
- W4376504313 type Work @default.
- W4376504313 citedByCount "0" @default.
- W4376504313 crossrefType "journal-article" @default.
- W4376504313 hasAuthorship W4376504313A5007588252 @default.
- W4376504313 hasAuthorship W4376504313A5014426597 @default.
- W4376504313 hasAuthorship W4376504313A5032033345 @default.
- W4376504313 hasAuthorship W4376504313A5040104075 @default.
- W4376504313 hasAuthorship W4376504313A5047310100 @default.
- W4376504313 hasAuthorship W4376504313A5051788626 @default.
- W4376504313 hasAuthorship W4376504313A5058254184 @default.
- W4376504313 hasAuthorship W4376504313A5059228473 @default.
- W4376504313 hasAuthorship W4376504313A5077288544 @default.
- W4376504313 hasAuthorship W4376504313A5086360069 @default.
- W4376504313 hasAuthorship W4376504313A5090429810 @default.
- W4376504313 hasAuthorship W4376504313A5091941388 @default.
- W4376504313 hasBestOaLocation W43765043131 @default.
- W4376504313 hasConcept C104317684 @default.
- W4376504313 hasConcept C126322002 @default.
- W4376504313 hasConcept C134018914 @default.
- W4376504313 hasConcept C148762608 @default.
- W4376504313 hasConcept C163950672 @default.
- W4376504313 hasConcept C169760540 @default.
- W4376504313 hasConcept C17619807 @default.
- W4376504313 hasConcept C201571599 @default.
- W4376504313 hasConcept C24586158 @default.
- W4376504313 hasConcept C2776804853 @default.
- W4376504313 hasConcept C2777668072 @default.
- W4376504313 hasConcept C2779134260 @default.