Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376505200> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4376505200 abstract "Abstract Cell division in bacteria requires the activation of FtsWI at the division site to synthesize septal peptidoglycan. In E. coli FtsN activates FtsWI and a previous model posited that the essential domain of FtsN ( E FtsN) acts on FtsQLB causing conformational changes so that a domain of FtsL, called AWI ( AWI FtsL), contacts FtsI resulting in activation of FtsW. In this study we use genetic analysis along with an AlphaFold2 model to test this activation model. Based on our findings we propose an updated model wherein the AWI FtsL and FtsI interaction is stabilized by E FtsN to activate FtsW and that this interaction is enhanced by the Cyto FtsN-FtsA interaction. Thus, FtsN acts as both a sensor for divisome assembly and an activator. In addition, we elucidate the role played by two critical FtsL residues in FtsW activation." @default.
- W4376505200 created "2023-05-15" @default.
- W4376505200 creator A5028364918 @default.
- W4376505200 creator A5036551619 @default.
- W4376505200 creator A5072233563 @default.
- W4376505200 creator A5074416433 @default.
- W4376505200 creator A5086565247 @default.
- W4376505200 date "2023-05-12" @default.
- W4376505200 modified "2023-10-17" @default.
- W4376505200 title "The essential domain of FtsN triggers cell division by promoting interaction between FtsL and FtsI" @default.
- W4376505200 cites W1829689588 @default.
- W4376505200 cites W1874187868 @default.
- W4376505200 cites W1964601681 @default.
- W4376505200 cites W2000180251 @default.
- W4376505200 cites W2003291728 @default.
- W4376505200 cites W2070067221 @default.
- W4376505200 cites W2118446544 @default.
- W4376505200 cites W2126211773 @default.
- W4376505200 cites W2142684354 @default.
- W4376505200 cites W2142779706 @default.
- W4376505200 cites W2154665917 @default.
- W4376505200 cites W2158336252 @default.
- W4376505200 cites W2161295469 @default.
- W4376505200 cites W2169641408 @default.
- W4376505200 cites W2171114517 @default.
- W4376505200 cites W2507914022 @default.
- W4376505200 cites W2810823843 @default.
- W4376505200 cites W2912238261 @default.
- W4376505200 cites W2948716905 @default.
- W4376505200 cites W3007864412 @default.
- W4376505200 cites W3012262711 @default.
- W4376505200 cites W3084307332 @default.
- W4376505200 cites W3112631654 @default.
- W4376505200 cites W3124098219 @default.
- W4376505200 cites W3153879570 @default.
- W4376505200 cites W3177828909 @default.
- W4376505200 cites W3193734521 @default.
- W4376505200 cites W4221066166 @default.
- W4376505200 cites W4295450565 @default.
- W4376505200 cites W4298140195 @default.
- W4376505200 cites W4308734100 @default.
- W4376505200 cites W4309757950 @default.
- W4376505200 cites W4310131567 @default.
- W4376505200 cites W4313588678 @default.
- W4376505200 cites W4362604766 @default.
- W4376505200 cites W4367599082 @default.
- W4376505200 doi "https://doi.org/10.1101/2023.05.12.540521" @default.
- W4376505200 hasPublicationYear "2023" @default.
- W4376505200 type Work @default.
- W4376505200 citedByCount "0" @default.
- W4376505200 crossrefType "posted-content" @default.
- W4376505200 hasAuthorship W4376505200A5028364918 @default.
- W4376505200 hasAuthorship W4376505200A5036551619 @default.
- W4376505200 hasAuthorship W4376505200A5072233563 @default.
- W4376505200 hasAuthorship W4376505200A5074416433 @default.
- W4376505200 hasAuthorship W4376505200A5086565247 @default.
- W4376505200 hasBestOaLocation W43765052001 @default.
- W4376505200 hasConcept C134306372 @default.
- W4376505200 hasConcept C1491633281 @default.
- W4376505200 hasConcept C170493617 @default.
- W4376505200 hasConcept C185592680 @default.
- W4376505200 hasConcept C33923547 @default.
- W4376505200 hasConcept C36503486 @default.
- W4376505200 hasConcept C55493867 @default.
- W4376505200 hasConcept C60798267 @default.
- W4376505200 hasConcept C85813293 @default.
- W4376505200 hasConcept C86803240 @default.
- W4376505200 hasConcept C88045685 @default.
- W4376505200 hasConcept C94375191 @default.
- W4376505200 hasConcept C95444343 @default.
- W4376505200 hasConceptScore W4376505200C134306372 @default.
- W4376505200 hasConceptScore W4376505200C1491633281 @default.
- W4376505200 hasConceptScore W4376505200C170493617 @default.
- W4376505200 hasConceptScore W4376505200C185592680 @default.
- W4376505200 hasConceptScore W4376505200C33923547 @default.
- W4376505200 hasConceptScore W4376505200C36503486 @default.
- W4376505200 hasConceptScore W4376505200C55493867 @default.
- W4376505200 hasConceptScore W4376505200C60798267 @default.
- W4376505200 hasConceptScore W4376505200C85813293 @default.
- W4376505200 hasConceptScore W4376505200C86803240 @default.
- W4376505200 hasConceptScore W4376505200C88045685 @default.
- W4376505200 hasConceptScore W4376505200C94375191 @default.
- W4376505200 hasConceptScore W4376505200C95444343 @default.
- W4376505200 hasLocation W43765052001 @default.
- W4376505200 hasOpenAccess W4376505200 @default.
- W4376505200 hasPrimaryLocation W43765052001 @default.
- W4376505200 hasRelatedWork W2003217768 @default.
- W4376505200 hasRelatedWork W2074265148 @default.
- W4376505200 hasRelatedWork W2075176708 @default.
- W4376505200 hasRelatedWork W2086056969 @default.
- W4376505200 hasRelatedWork W2100809095 @default.
- W4376505200 hasRelatedWork W2119116806 @default.
- W4376505200 hasRelatedWork W2141850041 @default.
- W4376505200 hasRelatedWork W2164763613 @default.
- W4376505200 hasRelatedWork W2412305136 @default.
- W4376505200 hasRelatedWork W4380422545 @default.
- W4376505200 isParatext "false" @default.
- W4376505200 isRetracted "false" @default.
- W4376505200 workType "article" @default.