FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376505678> ?p ?o ?g. }

• W4376505678 endingPage "106847" @default.
• W4376505678 startingPage "106847" @default.
• W4376505678 abstract "Guideline-based therapy (GBT) for pulmonary Mycobacterium abscessus (Mab) disease achieves sustained sputum culture conversion (SSCC) rates of 30%; this is reflected by poor efficacy of GBT in the hollow fiber system model of Mab (HFS-Mab), which killed ∼1.22 log10 CFU/mL. This study was performed to determine which clinical dose of omadacycline, a tetracycline antibiotic, should be used in combination therapy to treat pulmonary Mab disease for relapse-free cure.First, omadacycline intrapulmonary concentration-time profiles of seven daily doses were mimicked in the HFS-Mab model and exposures associated with optimal efficacy were identified. Second, 10,000 subject Monte-Carlo simulations were performed to determine whether oral omadacycline 300 mg/day achieved these optimal exposures. Third, a retrospective clinical study on omadacycline vs. primarily tigecycline-based salvage therapy was conducted to assess rates of SSCC and toxicity. Fourth, a single patient was recruited to validate the findings.Omadacycline efficacy in the HFS-Mab was 2.09 log10 CFU/mL at exposures achieved in >99% of patients on 300 mg/day omadacycline. In the retrospective study of omadacycline 300 mg/day-based combinations vs. comparators, SSCC was achieved in 8/10 vs. 1/9 (P=0.006), symptom improvement in 8/8 vs. 5/9 (P=0.033), toxicity in 0 vs. 9/9 (P<0.001), and therapy discontinuation due to toxicity in 0 vs. 3/9 (P<0.001) cases, respectively. In one prospectively recruited patient, omadacycline 300 mg/day salvage therapy achieved SSCC and symptom-resolution in 3 months.Based on the preclinical and clinical data, omadacycline 300 mg/day in combination regimens could be appropriate for testing in Phase III trials in patients with Mab pulmonary disease." @default.
• W4376505678 created "2023-05-15" @default.
• W4376505678 creator A5002750862 @default.
• W4376505678 creator A5005686659 @default.
• W4376505678 creator A5008418538 @default.
• W4376505678 creator A5015681486 @default.
• W4376505678 creator A5017847957 @default.
• W4376505678 creator A5020154341 @default.
• W4376505678 creator A5025165126 @default.
• W4376505678 creator A5028001292 @default.
• W4376505678 creator A5031628471 @default.
• W4376505678 creator A5073754878 @default.
• W4376505678 creator A5080477180 @default.
• W4376505678 creator A5090909903 @default.
• W4376505678 date "2023-07-01" @default.
• W4376505678 modified "2023-10-13" @default.
• W4376505678 title "Omadacycline pharmacokinetics/pharmacodynamics in the hollow fiber model and clinical validation of efficacy to treat pulmonary Mycobacterium abscessus disease" @default.
• W4376505678 cites W2098248535 @default.
• W4376505678 cites W2098836940 @default.
• W4376505678 cites W2100383609 @default.
• W4376505678 cites W2275249775 @default.
• W4376505678 cites W2282126872 @default.
• W4376505678 cites W2290548088 @default.
• W4376505678 cites W2324745084 @default.
• W4376505678 cites W2495237884 @default.
• W4376505678 cites W2736151488 @default.
• W4376505678 cites W2748145826 @default.
• W4376505678 cites W2761484209 @default.
• W4376505678 cites W2791765621 @default.
• W4376505678 cites W2904714090 @default.
• W4376505678 cites W2918699514 @default.
• W4376505678 cites W2922130975 @default.
• W4376505678 cites W2933819188 @default.
• W4376505678 cites W2954390328 @default.
• W4376505678 cites W2957517713 @default.
• W4376505678 cites W3004629968 @default.
• W4376505678 cites W3038160084 @default.
• W4376505678 cites W3049339260 @default.
• W4376505678 cites W3084287306 @default.
• W4376505678 cites W3108783541 @default.
• W4376505678 cites W3111111644 @default.
• W4376505678 cites W3120846591 @default.
• W4376505678 cites W4200344413 @default.
• W4376505678 cites W4213176233 @default.
• W4376505678 cites W4226467569 @default.
• W4376505678 cites W4283792059 @default.
• W4376505678 doi "https://doi.org/10.1016/j.ijantimicag.2023.106847" @default.
• W4376505678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37187338" @default.
• W4376505678 hasPublicationYear "2023" @default.
• W4376505678 type Work @default.
• W4376505678 citedByCount "4" @default.
• W4376505678 countsByYear W43765056782023 @default.
• W4376505678 crossrefType "journal-article" @default.
• W4376505678 hasAuthorship W4376505678A5002750862 @default.
• W4376505678 hasAuthorship W4376505678A5005686659 @default.
• W4376505678 hasAuthorship W4376505678A5008418538 @default.
• W4376505678 hasAuthorship W4376505678A5015681486 @default.
• W4376505678 hasAuthorship W4376505678A5017847957 @default.
• W4376505678 hasAuthorship W4376505678A5020154341 @default.
• W4376505678 hasAuthorship W4376505678A5025165126 @default.
• W4376505678 hasAuthorship W4376505678A5028001292 @default.
• W4376505678 hasAuthorship W4376505678A5031628471 @default.
• W4376505678 hasAuthorship W4376505678A5073754878 @default.
• W4376505678 hasAuthorship W4376505678A5080477180 @default.
• W4376505678 hasAuthorship W4376505678A5090909903 @default.
• W4376505678 hasConcept C111113717 @default.
• W4376505678 hasConcept C112705442 @default.
• W4376505678 hasConcept C126322002 @default.
• W4376505678 hasConcept C141071460 @default.
• W4376505678 hasConcept C185592680 @default.
• W4376505678 hasConcept C2777027569 @default.
• W4376505678 hasConcept C2778715236 @default.
• W4376505678 hasConcept C29730261 @default.
• W4376505678 hasConcept C501593827 @default.
• W4376505678 hasConcept C55493867 @default.
• W4376505678 hasConcept C71924100 @default.
• W4376505678 hasConcept C90924648 @default.
• W4376505678 hasConcept C98274493 @default.
• W4376505678 hasConceptScore W4376505678C111113717 @default.
• W4376505678 hasConceptScore W4376505678C112705442 @default.
• W4376505678 hasConceptScore W4376505678C126322002 @default.
• W4376505678 hasConceptScore W4376505678C141071460 @default.
• W4376505678 hasConceptScore W4376505678C185592680 @default.
• W4376505678 hasConceptScore W4376505678C2777027569 @default.
• W4376505678 hasConceptScore W4376505678C2778715236 @default.
• W4376505678 hasConceptScore W4376505678C29730261 @default.
• W4376505678 hasConceptScore W4376505678C501593827 @default.
• W4376505678 hasConceptScore W4376505678C55493867 @default.
• W4376505678 hasConceptScore W4376505678C71924100 @default.
• W4376505678 hasConceptScore W4376505678C90924648 @default.
• W4376505678 hasConceptScore W4376505678C98274493 @default.
• W4376505678 hasIssue "1" @default.
• W4376505678 hasLocation W43765056781 @default.
• W4376505678 hasLocation W43765056782 @default.
• W4376505678 hasOpenAccess W4376505678 @default.
• W4376505678 hasPrimaryLocation W43765056781 @default.
• W4376505678 hasRelatedWork W1758514097 @default.
• W4376505678 hasRelatedWork W1997101420 @default.

• next