Matches in SemOpenAlex for { <https://semopenalex.org/work/W43765314> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W43765314 endingPage "10" @default.
- W43765314 startingPage "806" @default.
- W43765314 abstract "to explore the effect of simvastatin on alveolar epithelial cells and the expression of vascular endothelial growth factor (VEGF) in cigarette smoking-induced emphysema in rats.twenty-four, 12-week-old healthy male and female Wistar rats were randomly divided into 4 groups of 6 each: a control (W) group, a smoking (Sm) group, a simvastatin (St) group, and a smoking-simvastatin (SmSt) group. The rats were simultaneously fed, and kept in individual cages for 16 weeks. The VEGF level in lung tissue and bronchoalveolar lavage fluid (BALF) of each group was measured by ELISA. The expression of VEGF mRNA was determined by RT-PCR. The expressions of VEGF and proliferating cell nuclear antigen (PCNA) were determined by two-step immunohistochemistry assay. One-way ANOVA and LSD-t test were used for statistical analysis.the percentage of PCNA-positively stained alveolar epithelial cells was significantly higher in the SmSt group [(10.3 ± 2.0)%] than in the Sm group [(4.8 ± 0.8)%]. The levels of VEGF in BALF and lung tissue homogenate of the SmSt group [(187 ± 15) ng/L and (6782 ± 50) ng/L] were similar to the W group [(200 ± 20) ng/L and (7558 ± 330) ng/L], but were significantly higher than that in the Sm group [(71 ± 16) ng/L and (4149 ± 110) ng/L]. VEGF expression in alveolar and bronchial epithelial cells of rats in the SmSt group [(67.7 ± 5.0)% and (49.0 ± 3.0)%], was similar to the W group [(68.3 ± 3.3)% and (51.3 ± 2.9)%]. But the level of VEGF expression was significantly increased as compared to that in the Sm group [(27.0 ± 5.9)% and (16.3 ± 2.7)%]. SmSt group vs Sm group t = 1.117 - 12.001, all P < 0.01.simvastatin ameliorated the development of cigarette smoke-induced COPD in rats, partly by promoting alveolar epithelial cell proliferation and up-regulating the expression of VEGF." @default.
- W43765314 created "2016-06-24" @default.
- W43765314 creator A5008816043 @default.
- W43765314 creator A5022711610 @default.
- W43765314 creator A5025670042 @default.
- W43765314 creator A5039928494 @default.
- W43765314 creator A5048076897 @default.
- W43765314 creator A5059736823 @default.
- W43765314 date "2010-11-01" @default.
- W43765314 modified "2023-09-26" @default.
- W43765314 title "[The effect of simvastatin on alveolar epithelial cells in cigarette smoking-induced emphysema]." @default.
- W43765314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21211366" @default.
- W43765314 hasPublicationYear "2010" @default.
- W43765314 type Work @default.
- W43765314 sameAs 43765314 @default.
- W43765314 citedByCount "1" @default.
- W43765314 countsByYear W437653142015 @default.
- W43765314 crossrefType "journal-article" @default.
- W43765314 hasAuthorship W43765314A5008816043 @default.
- W43765314 hasAuthorship W43765314A5022711610 @default.
- W43765314 hasAuthorship W43765314A5025670042 @default.
- W43765314 hasAuthorship W43765314A5039928494 @default.
- W43765314 hasAuthorship W43765314A5048076897 @default.
- W43765314 hasAuthorship W43765314A5059736823 @default.
- W43765314 hasConcept C126322002 @default.
- W43765314 hasConcept C142724271 @default.
- W43765314 hasConcept C16685009 @default.
- W43765314 hasConcept C167734588 @default.
- W43765314 hasConcept C204232928 @default.
- W43765314 hasConcept C2776329913 @default.
- W43765314 hasConcept C2777025900 @default.
- W43765314 hasConcept C2777714996 @default.
- W43765314 hasConcept C2777961210 @default.
- W43765314 hasConcept C34688535 @default.
- W43765314 hasConcept C71924100 @default.
- W43765314 hasConcept C99476002 @default.
- W43765314 hasConceptScore W43765314C126322002 @default.
- W43765314 hasConceptScore W43765314C142724271 @default.
- W43765314 hasConceptScore W43765314C16685009 @default.
- W43765314 hasConceptScore W43765314C167734588 @default.
- W43765314 hasConceptScore W43765314C204232928 @default.
- W43765314 hasConceptScore W43765314C2776329913 @default.
- W43765314 hasConceptScore W43765314C2777025900 @default.
- W43765314 hasConceptScore W43765314C2777714996 @default.
- W43765314 hasConceptScore W43765314C2777961210 @default.
- W43765314 hasConceptScore W43765314C34688535 @default.
- W43765314 hasConceptScore W43765314C71924100 @default.
- W43765314 hasConceptScore W43765314C99476002 @default.
- W43765314 hasIssue "11" @default.
- W43765314 hasLocation W437653141 @default.
- W43765314 hasOpenAccess W43765314 @default.
- W43765314 hasPrimaryLocation W437653141 @default.
- W43765314 hasRelatedWork W2005507972 @default.
- W43765314 hasRelatedWork W2352902689 @default.
- W43765314 hasRelatedWork W2353042561 @default.
- W43765314 hasRelatedWork W2359630989 @default.
- W43765314 hasRelatedWork W2361592379 @default.
- W43765314 hasRelatedWork W2362593139 @default.
- W43765314 hasRelatedWork W2364993338 @default.
- W43765314 hasRelatedWork W2371102848 @default.
- W43765314 hasRelatedWork W2376089250 @default.
- W43765314 hasRelatedWork W2379363471 @default.
- W43765314 hasRelatedWork W2386050195 @default.
- W43765314 hasRelatedWork W2388010920 @default.
- W43765314 hasRelatedWork W2976474347 @default.
- W43765314 hasRelatedWork W3029813364 @default.
- W43765314 hasRelatedWork W3029943987 @default.
- W43765314 hasRelatedWork W3030858245 @default.
- W43765314 hasRelatedWork W3031204873 @default.
- W43765314 hasRelatedWork W3031255824 @default.
- W43765314 hasRelatedWork W3031498264 @default.
- W43765314 hasRelatedWork W3031861424 @default.
- W43765314 hasVolume "33" @default.
- W43765314 isParatext "false" @default.
- W43765314 isRetracted "false" @default.
- W43765314 magId "43765314" @default.
- W43765314 workType "article" @default.