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- W4376570077 abstract "Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and its global health burden is increasing. COPD is characterized by emphysema, mucus hypersecretion, and persistent lung inflammation, and clinically by chronic airflow obstruction and symptoms of dyspnea, cough, and fatigue in patients. A cluster of pathologies including chronic bronchitis, emphysema, asthma, and cardiovascular disease in the form of hypertension and atherosclerosis variably coexist in COPD patients. Underlying causes for COPD include primarily tobacco use but may also be driven by exposure to air pollutants, biomass burning, and workplace related fumes and chemicals. While no single animal model might mimic all features of human COPD, a wide variety of published models have collectively helped to improve our understanding of disease processes involved in the genesis and persistence of COPD. In this review, the pathogenesis and associated risk factors of COPD are examined in different mammalian models of the disease. Each animal model included in this review is exclusively created by tobacco smoke (TS) exposure. As animal models continue to aid in defining the pathobiological mechanisms of and possible novel therapeutic interventions for COPD, the advantages and disadvantages of each animal model are discussed." @default.
- W4376570077 created "2023-05-16" @default.
- W4376570077 creator A5025948019 @default.
- W4376570077 creator A5027437494 @default.
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- W4376570077 creator A5067957544 @default.
- W4376570077 creator A5091755450 @default.
- W4376570077 date "2023-05-14" @default.
- W4376570077 modified "2023-09-23" @default.
- W4376570077 title "Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)" @default.
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