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• W4376573630 endingPage "275" @default.
• W4376573630 startingPage "257" @default.
• W4376573630 abstract "Head and neck squamous cell carcinoma (HNSCC) is a challenging disease to treat because of typically late-stage diagnoses and tumor formation in difficult-to-treat areas, sensitive to aggressive or invasive treatments. To date, HNSCC treatments have been limited to surgery, radiotherapy, and chemotherapy, which may have significant morbidity and often lead to long-lasting side effects. The development of immunotherapies has revolutionized cancer treatment by providing a promising alternative to standard-of-care therapies. However, single-agent immunotherapy has been only modestly effective in the treatment of various cancers, including HNSCC, with most patients receiving no overall benefit or increased survival. In addition, single-agent immunotherapy's limitations, namely immune-related side effects and the necessity of multidose treatments, must be addressed to further improve treatment efficacy. Biocompatible biomaterials, in combination with cancer immunotherapies, offer numerous advantages in the concentration, localization, and controlled release of drugs, cancer antigens, and immune cells. Biomaterial structures are diverse, and their design can generally be customized to enhance immunotherapy response. In preclinical settings, the use of biomaterials has shown great promise in improving the efficacy of single-agent immunotherapy. Herein, we provide an overview of current immunotherapy treatments for HNSCC and their limitations, as well as the potential applications of biomaterials in enhancing cancer immunotherapies. Impact Statement Advances in anticancer immunotherapies for the past 30 years have yielded exciting clinical results and provided alternatives to long-standing standard-of-care treatments, which are associated with significant toxicities and long-term morbidity. However, patients with head and neck squamous cell carcinoma (HNSCC) have not benefited from immunotherapies as much as patients with other cancers. Immunotherapy limitations include systemic side effects, therapeutic resistance, poor delivery kinetics, and limited patient responses. Biomaterial-enhanced immunotherapies, as explored in this review, are a potentially powerful means of achieving localized drug delivery, sustained and controlled drug release, and immunomodulation. They may overcome current treatment limitations and improve patient outcomes and care." @default.
• W4376573630 created "2023-05-17" @default.
• W4376573630 creator A5035973740 @default.
• W4376573630 creator A5057490939 @default.
• W4376573630 creator A5071074539 @default.
• W4376573630 creator A5082834975 @default.
• W4376573630 date "2023-06-01" @default.
• W4376573630 modified "2023-09-24" @default.
• W4376573630 title "Enhancement of Immunotherapies in Head and Neck Cancers Using Biomaterial-Based Treatment Strategies" @default.
• W4376573630 cites W1532689189 @default.
• W4376573630 cites W1580407891 @default.
• W4376573630 cites W1800636867 @default.
• W4376573630 cites W1819195094 @default.
• W4376573630 cites W1967245379 @default.
• W4376573630 cites W1970558633 @default.
• W4376573630 cites W1971180916 @default.
• W4376573630 cites W1981318340 @default.
• W4376573630 cites W1983412131 @default.
• W4376573630 cites W2000770184 @default.
• W4376573630 cites W2004150448 @default.
• W4376573630 cites W2004630197 @default.
• W4376573630 cites W2012257771 @default.
• W4376573630 cites W2018590888 @default.
• W4376573630 cites W2019060070 @default.
• W4376573630 cites W2021170305 @default.
• W4376573630 cites W2022495797 @default.
• W4376573630 cites W2056572016 @default.
• W4376573630 cites W2068890283 @default.
• W4376573630 cites W2072466513 @default.
• W4376573630 cites W2083616533 @default.
• W4376573630 cites W2086550310 @default.
• W4376573630 cites W2090459898 @default.
• W4376573630 cites W2100012403 @default.
• W4376573630 cites W2101601223 @default.
• W4376573630 cites W2102648502 @default.
• W4376573630 cites W2113875809 @default.
• W4376573630 cites W2114133742 @default.
• W4376573630 cites W2118968285 @default.
• W4376573630 cites W2118982164 @default.
• W4376573630 cites W2124891284 @default.
• W4376573630 cites W2128730859 @default.
• W4376573630 cites W2133539678 @default.
• W4376573630 cites W2138271749 @default.
• W4376573630 cites W2139340015 @default.
• W4376573630 cites W2143163879 @default.
• W4376573630 cites W2148523692 @default.
• W4376573630 cites W2149166037 @default.
• W4376573630 cites W2149694154 @default.
• W4376573630 cites W2163814058 @default.
• W4376573630 cites W2169088092 @default.
• W4376573630 cites W2169908694 @default.
• W4376573630 cites W2192516032 @default.
• W4376573630 cites W2201309545 @default.
• W4376573630 cites W2208179253 @default.
• W4376573630 cites W2266959491 @default.
• W4376573630 cites W2271865536 @default.
• W4376573630 cites W2283318802 @default.
• W4376573630 cites W2283809829 @default.
• W4376573630 cites W2529484692 @default.
• W4376573630 cites W2537963082 @default.
• W4376573630 cites W2560367415 @default.
• W4376573630 cites W2572174216 @default.
• W4376573630 cites W2605497049 @default.
• W4376573630 cites W2742399016 @default.
• W4376573630 cites W2764109781 @default.
• W4376573630 cites W2768429453 @default.
• W4376573630 cites W2790881625 @default.
• W4376573630 cites W2791182757 @default.
• W4376573630 cites W2791931250 @default.
• W4376573630 cites W2800127497 @default.
• W4376573630 cites W2808870773 @default.
• W4376573630 cites W2884126108 @default.
• W4376573630 cites W2887370435 @default.
• W4376573630 cites W2888600909 @default.
• W4376573630 cites W2892995292 @default.
• W4376573630 cites W2898717093 @default.
• W4376573630 cites W2900046418 @default.
• W4376573630 cites W2900478118 @default.
• W4376573630 cites W2901772305 @default.
• W4376573630 cites W2903493423 @default.
• W4376573630 cites W2905972499 @default.
• W4376573630 cites W2912711791 @default.
• W4376573630 cites W2913570482 @default.
• W4376573630 cites W2914084076 @default.
• W4376573630 cites W2943472333 @default.
• W4376573630 cites W2944164211 @default.
• W4376573630 cites W2955839328 @default.
• W4376573630 cites W2958648554 @default.
• W4376573630 cites W2963876800 @default.
• W4376573630 cites W2970204123 @default.
• W4376573630 cites W2975889253 @default.
• W4376573630 cites W2979490280 @default.
• W4376573630 cites W2985859698 @default.
• W4376573630 cites W2988506530 @default.
• W4376573630 cites W2994800539 @default.
• W4376573630 cites W2996862224 @default.
• W4376573630 cites W3001232216 @default.
• W4376573630 cites W3007976037 @default.

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