FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376598482> ?p ?o ?g. }

• W4376598482 endingPage "1151.e10" @default.
• W4376598482 startingPage "1134" @default.
• W4376598482 abstract "Glioblastomas are aggressive brain tumors that are largely immunotherapy resistant. This is associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T cell infiltration. LIGHT/TNFSF14 can induce high endothelial venules (HEVs) and tertiary lymphoid structures (TLS), suggesting that its therapeutic expression could promote T cell recruitment. Here, we use a brain endothelial cell-targeted adeno-associated viral (AAV) vector to express LIGHT in the glioma vasculature (AAV-LIGHT). We found that systemic AAV-LIGHT treatment induces tumor-associated HEVs and T cell-rich TLS, prolonging survival in αPD-1-resistant murine glioma. AAV-LIGHT treatment reduces T cell exhaustion and promotes TCF1+CD8+ stem-like T cells, which reside in TLS and intratumoral antigen-presenting niches. Tumor regression upon AAV-LIGHT therapy correlates with tumor-specific cytotoxic/memory T cell responses. Our work reveals that altering vascular phenotype through vessel-targeted expression of LIGHT promotes efficient anti-tumor T cell responses and prolongs survival in glioma. These findings have broader implications for treatment of other immunotherapy-resistant cancers." @default.
• W4376598482 created "2023-05-17" @default.
• W4376598482 creator A5002879073 @default.
• W4376598482 creator A5004585831 @default.
• W4376598482 creator A5004593392 @default.
• W4376598482 creator A5011954889 @default.
• W4376598482 creator A5015281429 @default.
• W4376598482 creator A5016459436 @default.
• W4376598482 creator A5023771352 @default.
• W4376598482 creator A5024939594 @default.
• W4376598482 creator A5026470819 @default.
• W4376598482 creator A5026894578 @default.
• W4376598482 creator A5037532882 @default.
• W4376598482 creator A5047816668 @default.
• W4376598482 creator A5054611915 @default.
• W4376598482 creator A5065643443 @default.
• W4376598482 creator A5069463399 @default.
• W4376598482 creator A5074102832 @default.
• W4376598482 creator A5085087940 @default.
• W4376598482 creator A5087314005 @default.
• W4376598482 creator A5090354704 @default.
• W4376598482 creator A5091944827 @default.
• W4376598482 date "2023-06-01" @default.
• W4376598482 modified "2023-10-16" @default.
• W4376598482 title "Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma" @default.
• W4376598482 cites W1931024094 @default.
• W4376598482 cites W2002149160 @default.
• W4376598482 cites W2006294581 @default.
• W4376598482 cites W2010065190 @default.
• W4376598482 cites W2017193637 @default.
• W4376598482 cites W2046560134 @default.
• W4376598482 cites W2072715223 @default.
• W4376598482 cites W2096287682 @default.
• W4376598482 cites W2101335891 @default.
• W4376598482 cites W2104958914 @default.
• W4376598482 cites W2118818657 @default.
• W4376598482 cites W2123882956 @default.
• W4376598482 cites W2124736921 @default.
• W4376598482 cites W2153060970 @default.
• W4376598482 cites W2160872052 @default.
• W4376598482 cites W2191777694 @default.
• W4376598482 cites W2205491921 @default.
• W4376598482 cites W2339068621 @default.
• W4376598482 cites W2339442385 @default.
• W4376598482 cites W2506616866 @default.
• W4376598482 cites W2528849844 @default.
• W4376598482 cites W2580929880 @default.
• W4376598482 cites W2592935721 @default.
• W4376598482 cites W2605792367 @default.
• W4376598482 cites W2606167786 @default.
• W4376598482 cites W2616922646 @default.
• W4376598482 cites W2753095840 @default.
• W4376598482 cites W2754092421 @default.
• W4376598482 cites W2782321008 @default.
• W4376598482 cites W2792662803 @default.
• W4376598482 cites W2794947378 @default.
• W4376598482 cites W2889555301 @default.
• W4376598482 cites W2899145148 @default.
• W4376598482 cites W2909486828 @default.
• W4376598482 cites W2911752971 @default.
• W4376598482 cites W2913558101 @default.
• W4376598482 cites W2913623258 @default.
• W4376598482 cites W2916020270 @default.
• W4376598482 cites W2917158435 @default.
• W4376598482 cites W2920526722 @default.
• W4376598482 cites W2945057866 @default.
• W4376598482 cites W2947501174 @default.
• W4376598482 cites W2951843883 @default.
• W4376598482 cites W2952481429 @default.
• W4376598482 cites W2981871227 @default.
• W4376598482 cites W2991888163 @default.
• W4376598482 cites W2994938720 @default.
• W4376598482 cites W2998795792 @default.
• W4376598482 cites W3000311037 @default.
• W4376598482 cites W3025165241 @default.
• W4376598482 cites W3026551532 @default.
• W4376598482 cites W3034695976 @default.
• W4376598482 cites W3035540747 @default.
• W4376598482 cites W3047463220 @default.
• W4376598482 cites W3111462718 @default.
• W4376598482 cites W3120538773 @default.
• W4376598482 cites W3150063851 @default.
• W4376598482 cites W3155053457 @default.
• W4376598482 cites W3194247868 @default.
• W4376598482 cites W3198005493 @default.
• W4376598482 cites W3217143832 @default.
• W4376598482 cites W4200418659 @default.
• W4376598482 cites W4205894363 @default.
• W4376598482 cites W4210339030 @default.
• W4376598482 cites W4220906455 @default.
• W4376598482 cites W4242818520 @default.
• W4376598482 cites W4313887854 @default.
• W4376598482 doi "https://doi.org/10.1016/j.ccell.2023.04.010" @default.
• W4376598482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37172581" @default.
• W4376598482 hasPublicationYear "2023" @default.
• W4376598482 type Work @default.
• W4376598482 citedByCount "2" @default.
• W4376598482 countsByYear W43765984822023 @default.

• next