Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376601289> ?p ?o ?g. }
- W4376601289 endingPage "103617" @default.
- W4376601289 startingPage "103617" @default.
- W4376601289 abstract "Hepatitis B virus (HBV) infection is a major global health problem that puts people at high risk of death from cirrhosis and liver cancer. The presence of covalently closed circular DNA (cccDNA) in infected cells is considered to be the main obstacle to curing chronic hepatitis B. At present, the cccDNA cannot be completely eliminated by standard treatments. There is an urgent need to develop drugs or therapies that can reduce HBV cccDNA levels in infected cells. We summarize the discovery and optimization of small molecules that target cccDNA synthesis and degradation. These compounds are cccDNA synthesis inhibitors, cccDNA reducers, core protein allosteric modulators, ribonuclease H inhibitors, cccDNA transcriptional modulators, HBx inhibitors and other small molecules that reduce cccDNA levels." @default.
- W4376601289 created "2023-05-17" @default.
- W4376601289 creator A5004366253 @default.
- W4376601289 creator A5013746699 @default.
- W4376601289 creator A5035724323 @default.
- W4376601289 creator A5051434566 @default.
- W4376601289 creator A5059468550 @default.
- W4376601289 creator A5061687469 @default.
- W4376601289 creator A5081785928 @default.
- W4376601289 creator A5090391719 @default.
- W4376601289 date "2023-07-01" @default.
- W4376601289 modified "2023-09-27" @default.
- W4376601289 title "Targeting hepatitis B virus cccDNA levels: Recent progress in seeking small molecule drug candidates" @default.
- W4376601289 cites W1501417543 @default.
- W4376601289 cites W1862974635 @default.
- W4376601289 cites W1979009813 @default.
- W4376601289 cites W1988761020 @default.
- W4376601289 cites W1996711919 @default.
- W4376601289 cites W2002969023 @default.
- W4376601289 cites W2006867673 @default.
- W4376601289 cites W2014080406 @default.
- W4376601289 cites W2016995625 @default.
- W4376601289 cites W2023843484 @default.
- W4376601289 cites W2035920453 @default.
- W4376601289 cites W2042396550 @default.
- W4376601289 cites W2043861742 @default.
- W4376601289 cites W2044238216 @default.
- W4376601289 cites W2045108297 @default.
- W4376601289 cites W2051173965 @default.
- W4376601289 cites W2081813064 @default.
- W4376601289 cites W2087957920 @default.
- W4376601289 cites W2089108066 @default.
- W4376601289 cites W2092193247 @default.
- W4376601289 cites W2098458274 @default.
- W4376601289 cites W2108892218 @default.
- W4376601289 cites W2120426460 @default.
- W4376601289 cites W2131605289 @default.
- W4376601289 cites W2139219723 @default.
- W4376601289 cites W2143956038 @default.
- W4376601289 cites W2145137950 @default.
- W4376601289 cites W2147084784 @default.
- W4376601289 cites W2154097176 @default.
- W4376601289 cites W2155363168 @default.
- W4376601289 cites W2158728342 @default.
- W4376601289 cites W2164322519 @default.
- W4376601289 cites W2167203718 @default.
- W4376601289 cites W2168779657 @default.
- W4376601289 cites W2294472239 @default.
- W4376601289 cites W2338215546 @default.
- W4376601289 cites W2418554548 @default.
- W4376601289 cites W2518924844 @default.
- W4376601289 cites W2541628542 @default.
- W4376601289 cites W2553908226 @default.
- W4376601289 cites W2561358839 @default.
- W4376601289 cites W2588574024 @default.
- W4376601289 cites W2611875906 @default.
- W4376601289 cites W2622834744 @default.
- W4376601289 cites W2713927065 @default.
- W4376601289 cites W2729133950 @default.
- W4376601289 cites W2759319254 @default.
- W4376601289 cites W2768958964 @default.
- W4376601289 cites W2778928474 @default.
- W4376601289 cites W2793638189 @default.
- W4376601289 cites W2801167100 @default.
- W4376601289 cites W2809177606 @default.
- W4376601289 cites W2898602894 @default.
- W4376601289 cites W2899386618 @default.
- W4376601289 cites W2907762216 @default.
- W4376601289 cites W2909653220 @default.
- W4376601289 cites W2911063796 @default.
- W4376601289 cites W2914843948 @default.
- W4376601289 cites W2933300836 @default.
- W4376601289 cites W2974535357 @default.
- W4376601289 cites W2978828198 @default.
- W4376601289 cites W2980699734 @default.
- W4376601289 cites W2981056659 @default.
- W4376601289 cites W2982130264 @default.
- W4376601289 cites W2982149836 @default.
- W4376601289 cites W2997606107 @default.
- W4376601289 cites W3007254861 @default.
- W4376601289 cites W3027504226 @default.
- W4376601289 cites W3047272847 @default.
- W4376601289 cites W3081911856 @default.
- W4376601289 cites W3082987907 @default.
- W4376601289 cites W3089298983 @default.
- W4376601289 cites W3093421147 @default.
- W4376601289 cites W3099330130 @default.
- W4376601289 cites W3107924035 @default.
- W4376601289 cites W3108038776 @default.
- W4376601289 cites W3112748725 @default.
- W4376601289 cites W3121573458 @default.
- W4376601289 cites W3180576386 @default.
- W4376601289 cites W3213255205 @default.
- W4376601289 cites W4206082932 @default.
- W4376601289 cites W4226342213 @default.
- W4376601289 cites W4284680599 @default.
- W4376601289 cites W4292002366 @default.
- W4376601289 cites W4292342666 @default.