Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376602103> ?p ?o ?g. }
- W4376602103 endingPage "33" @default.
- W4376602103 startingPage "24" @default.
- W4376602103 abstract "Reactive oxygen species are considered a cause of neuronal cell death in Alzheimer’s disease (AD). Abnormal tau phosphorylation is a proven pathological hallmark of AD. Microtubule affinity-regulating kinases (MARKs) regulate tau-microtubule binding and play a crucial role in neuronal survival. In this study, we hypothesized that oxidative stress increases the phosphorylation of Ser262 of tau protein through activation of MARKs, which is the main reason for the development of AD. We investigated the relationship between tau hyperphosphorylation on Ser262 and MARKs in N1E-115 cells subjected to oxidative stress by exposure to a low concentration of hydrogen peroxide. This work builds on the observation that hyperphosphorylation of tau is significantly increased by oxidative stress. MARKs activation correlated with tau hyperphosphorylation at Ser262, a site that is essential to maintain microtubule stability and is the initial phosphorylation site in AD. These results indicated that MARKs inhibitors might serve a role as therapeutic tools for the treatment of AD." @default.
- W4376602103 created "2023-05-17" @default.
- W4376602103 creator A5003605709 @default.
- W4376602103 creator A5004326219 @default.
- W4376602103 creator A5077273115 @default.
- W4376602103 date "2023-01-01" @default.
- W4376602103 modified "2023-09-25" @default.
- W4376602103 title "Oxidative stress induces tau hyperphosphorylation via MARK activation in neuroblastoma N1E-115 cells" @default.
- W4376602103 cites W1595993343 @default.
- W4376602103 cites W179780591 @default.
- W4376602103 cites W1927347955 @default.
- W4376602103 cites W1971744915 @default.
- W4376602103 cites W1972136736 @default.
- W4376602103 cites W1980389635 @default.
- W4376602103 cites W1980768099 @default.
- W4376602103 cites W1984652813 @default.
- W4376602103 cites W1997198091 @default.
- W4376602103 cites W2001410029 @default.
- W4376602103 cites W2001443225 @default.
- W4376602103 cites W2006717582 @default.
- W4376602103 cites W2013124661 @default.
- W4376602103 cites W2015717646 @default.
- W4376602103 cites W2020752075 @default.
- W4376602103 cites W2022402045 @default.
- W4376602103 cites W2026737475 @default.
- W4376602103 cites W2027826877 @default.
- W4376602103 cites W2029231027 @default.
- W4376602103 cites W2031160252 @default.
- W4376602103 cites W2034336290 @default.
- W4376602103 cites W2036145275 @default.
- W4376602103 cites W2037537078 @default.
- W4376602103 cites W2041956586 @default.
- W4376602103 cites W2051788959 @default.
- W4376602103 cites W2073647365 @default.
- W4376602103 cites W2074769970 @default.
- W4376602103 cites W2078467746 @default.
- W4376602103 cites W2081514970 @default.
- W4376602103 cites W2082429191 @default.
- W4376602103 cites W2084593700 @default.
- W4376602103 cites W2094373312 @default.
- W4376602103 cites W2098358894 @default.
- W4376602103 cites W2103969373 @default.
- W4376602103 cites W2108049372 @default.
- W4376602103 cites W2111200377 @default.
- W4376602103 cites W2114205908 @default.
- W4376602103 cites W2117526022 @default.
- W4376602103 cites W2126522816 @default.
- W4376602103 cites W2128212230 @default.
- W4376602103 cites W2135061761 @default.
- W4376602103 cites W2138600972 @default.
- W4376602103 cites W2140665078 @default.
- W4376602103 cites W2142406924 @default.
- W4376602103 cites W2142964430 @default.
- W4376602103 cites W2143031051 @default.
- W4376602103 cites W2143498800 @default.
- W4376602103 cites W2150217973 @default.
- W4376602103 cites W2158278714 @default.
- W4376602103 cites W2170597525 @default.
- W4376602103 cites W2325575548 @default.
- W4376602103 cites W2507448922 @default.
- W4376602103 cites W2529470828 @default.
- W4376602103 cites W2595372664 @default.
- W4376602103 cites W2887589796 @default.
- W4376602103 cites W2913515678 @default.
- W4376602103 cites W2985611265 @default.
- W4376602103 cites W3093256949 @default.
- W4376602103 cites W37138378 @default.
- W4376602103 cites W4230049608 @default.
- W4376602103 cites W4253780688 @default.
- W4376602103 cites W70729731 @default.
- W4376602103 doi "https://doi.org/10.3164/jcbn.22-39" @default.
- W4376602103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37534088" @default.
- W4376602103 hasPublicationYear "2023" @default.
- W4376602103 type Work @default.
- W4376602103 citedByCount "0" @default.
- W4376602103 crossrefType "journal-article" @default.
- W4376602103 hasAuthorship W4376602103A5003605709 @default.
- W4376602103 hasAuthorship W4376602103A5004326219 @default.
- W4376602103 hasAuthorship W4376602103A5077273115 @default.
- W4376602103 hasBestOaLocation W43766021031 @default.
- W4376602103 hasConcept C11960822 @default.
- W4376602103 hasConcept C126322002 @default.
- W4376602103 hasConcept C169760540 @default.
- W4376602103 hasConcept C184235292 @default.
- W4376602103 hasConcept C185592680 @default.
- W4376602103 hasConcept C190283241 @default.
- W4376602103 hasConcept C20418707 @default.
- W4376602103 hasConcept C2776151105 @default.
- W4376602103 hasConcept C2778198054 @default.
- W4376602103 hasConcept C2778670691 @default.
- W4376602103 hasConcept C2779134260 @default.
- W4376602103 hasConcept C31573885 @default.
- W4376602103 hasConcept C48349386 @default.
- W4376602103 hasConcept C502032728 @default.
- W4376602103 hasConcept C55493867 @default.
- W4376602103 hasConcept C57600042 @default.
- W4376602103 hasConcept C71924100 @default.
- W4376602103 hasConcept C86803240 @default.