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- W4376602927 endingPage "804" @default.
- W4376602927 startingPage "793" @default.
- W4376602927 abstract "Motivations for understanding the underlying mechanisms of alcohol toxicity range from economical to toxicological and clinical. On the one hand, acute alcohol toxicity limits biofuel yields, and on the other hand, acute alcohol toxicity provides a vital defense mechanism to prevent the spread of disease. Herein the role that stored curvature elastic energy (SCE) in biological membranes might play in alcohol toxicity is discussed, for both short and long-chain alcohols. Structure–toxicity relationships for alcohols ranging from methanol to hexadecanol are collated, and estimates of alcohol toxicity per alcohol molecule in the cell membrane are made. The latter reveal a minimum toxicity value per molecule around butanol before alcohol toxicity per molecule increases to a maximum around decanol and subsequently decreases again. The impact of alcohol molecules on the lamellar to inverse hexagonal phase transition temperature (TH) is then presented and used as a metric to assess the impact of alcohol molecules on SCE. This approach suggests the nonmonotonic relationship between alcohol toxicity and chain length is consistent with SCE being a target of alcohol toxicity. Finally, in vivo evidence for SCE-driven adaptations to alcohol toxicity in the literature are discussed." @default.
- W4376602927 created "2023-05-17" @default.
- W4376602927 creator A5074940559 @default.
- W4376602927 date "2023-05-15" @default.
- W4376602927 modified "2023-09-24" @default.
- W4376602927 title "A Membrane Biophysics Perspective on the Mechanism of Alcohol Toxicity" @default.
- W4376602927 cites W117836240 @default.
- W4376602927 cites W1494354761 @default.
- W4376602927 cites W1560754586 @default.
- W4376602927 cites W1595848030 @default.
- W4376602927 cites W1837910522 @default.
- W4376602927 cites W1941913237 @default.
- W4376602927 cites W1964545682 @default.
- W4376602927 cites W1965382738 @default.
- W4376602927 cites W1966132849 @default.
- W4376602927 cites W1970778844 @default.
- W4376602927 cites W1974240505 @default.
- W4376602927 cites W1975882538 @default.
- W4376602927 cites W1976081665 @default.
- W4376602927 cites W1976580692 @default.
- W4376602927 cites W1981230796 @default.
- W4376602927 cites W1982659677 @default.
- W4376602927 cites W1983265918 @default.
- W4376602927 cites W1983864363 @default.
- W4376602927 cites W1987412355 @default.
- W4376602927 cites W1991655565 @default.
- W4376602927 cites W1993233471 @default.
- W4376602927 cites W1993546854 @default.
- W4376602927 cites W1994330421 @default.
- W4376602927 cites W1995766554 @default.
- W4376602927 cites W1999916584 @default.
- W4376602927 cites W2001054241 @default.
- W4376602927 cites W2003507857 @default.
- W4376602927 cites W2004163609 @default.
- W4376602927 cites W2005889858 @default.
- W4376602927 cites W2006881455 @default.
- W4376602927 cites W2007483105 @default.
- W4376602927 cites W2007917914 @default.
- W4376602927 cites W2008941155 @default.
- W4376602927 cites W2013993741 @default.
- W4376602927 cites W2014407854 @default.
- W4376602927 cites W2015006957 @default.
- W4376602927 cites W2015925800 @default.
- W4376602927 cites W2016572177 @default.
- W4376602927 cites W2018162918 @default.
- W4376602927 cites W2018259963 @default.
- W4376602927 cites W2018900121 @default.
- W4376602927 cites W2019024574 @default.
- W4376602927 cites W2019284815 @default.
- W4376602927 cites W2020835297 @default.
- W4376602927 cites W2021178815 @default.
- W4376602927 cites W2021617336 @default.
- W4376602927 cites W2023914265 @default.
- W4376602927 cites W2023918139 @default.
- W4376602927 cites W2026375146 @default.
- W4376602927 cites W2027967288 @default.
- W4376602927 cites W2028736491 @default.
- W4376602927 cites W2030823283 @default.
- W4376602927 cites W2030985530 @default.
- W4376602927 cites W2036814435 @default.
- W4376602927 cites W2036880132 @default.
- W4376602927 cites W2037154092 @default.
- W4376602927 cites W2039020982 @default.
- W4376602927 cites W2042873577 @default.
- W4376602927 cites W2044428019 @default.
- W4376602927 cites W2050451385 @default.
- W4376602927 cites W2056671160 @default.
- W4376602927 cites W2057893343 @default.
- W4376602927 cites W2059187763 @default.
- W4376602927 cites W2060117430 @default.
- W4376602927 cites W2060872711 @default.
- W4376602927 cites W2062664883 @default.
- W4376602927 cites W2064250293 @default.
- W4376602927 cites W2064875808 @default.
- W4376602927 cites W2066101121 @default.
- W4376602927 cites W2069372169 @default.
- W4376602927 cites W2069507486 @default.
- W4376602927 cites W2070860887 @default.
- W4376602927 cites W2073027319 @default.
- W4376602927 cites W2073816348 @default.
- W4376602927 cites W2073902009 @default.
- W4376602927 cites W2076485843 @default.
- W4376602927 cites W2077191504 @default.
- W4376602927 cites W2079037879 @default.
- W4376602927 cites W2080995069 @default.
- W4376602927 cites W2082537227 @default.
- W4376602927 cites W2082755780 @default.
- W4376602927 cites W2083406539 @default.
- W4376602927 cites W2085323554 @default.
- W4376602927 cites W2087417853 @default.
- W4376602927 cites W2094234199 @default.
- W4376602927 cites W2095919951 @default.
- W4376602927 cites W2102780437 @default.
- W4376602927 cites W2111097620 @default.
- W4376602927 cites W2113566706 @default.
- W4376602927 cites W2118798045 @default.
- W4376602927 cites W2121963527 @default.
- W4376602927 cites W2124736379 @default.