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• W4376603154 abstract "In retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), the photoreceptors become stressed and start to degenerate in the early stages of the disease. Retinal prosthetic devices have been developed to restore vision in patients by applying electrical stimulation to the surviving retinal cells. However, these devices provide limited visual perception as the therapeutic interventions are generally considered in the later stages of the disease when only inner retinal layer cells are left. A potential treatment option for retinal degenerative diseases in the early stages can be stimulating bipolar cells, which receive presynaptic signals from photoreceptors. In this work, we constructed computational models of healthy and degenerated (both ON and OFF-type) cone bipolar cells (CBCs) with realistic morphologies extracted from connectomes of the healthy and early-stage degenerated rabbit retina. We examined these cells' membrane potential and axon terminal calcium current differences when subjected to electrical stimulation. In addition, we investigated how differently healthy and degenerated cells behave with respect to various stimulation parameters, including pulse duration and cells' distance from the stimulating electrode. The results suggested that regardless of the position of the OFF CBCs in the retina model, there is not a significant difference between the membrane potential of healthy and degenerate cells when electrically stimulated. However, the healthy ON CBC axon terminal membrane potential rising time-constant is shorter (0.29 ± 0.03 ms) than the degenerated cells (0.8 ± 0.07 ms). Moreover, the ionic calcium channels at the axon terminals of the cells have a higher concentration and higher current in degenerated cells (32.24 ± 6.12 pA) than the healthy cells (13.64 ± 2.88 pA) independently of the cell's position." @default.
• W4376603154 created "2023-05-17" @default.
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• W4376603154 date "2023-01-01" @default.
• W4376603154 modified "2023-10-14" @default.
• W4376603154 title "Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation" @default.
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• W4376603154 cites W1860446288 @default.
• W4376603154 cites W1860608840 @default.
• W4376603154 cites W1972006822 @default.
• W4376603154 cites W1972072039 @default.
• W4376603154 cites W1975606674 @default.
• W4376603154 cites W1975813079 @default.
• W4376603154 cites W1979353221 @default.
• W4376603154 cites W1979752294 @default.
• W4376603154 cites W1989396876 @default.
• W4376603154 cites W1996727793 @default.
• W4376603154 cites W2006028506 @default.
• W4376603154 cites W2007409841 @default.
• W4376603154 cites W2011826381 @default.
• W4376603154 cites W2016971620 @default.
• W4376603154 cites W2026377076 @default.
• W4376603154 cites W2027106449 @default.
• W4376603154 cites W2028664367 @default.
• W4376603154 cites W2031131256 @default.
• W4376603154 cites W2031675933 @default.
• W4376603154 cites W2032534043 @default.
• W4376603154 cites W2034822533 @default.
• W4376603154 cites W2038841717 @default.
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• W4376603154 cites W2082235213 @default.
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• W4376603154 cites W2117120818 @default.
• W4376603154 cites W2120208152 @default.
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• W4376603154 cites W2127023470 @default.
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• W4376603154 cites W2168509949 @default.
• W4376603154 cites W2209723663 @default.
• W4376603154 cites W2242060951 @default.
• W4376603154 cites W2282996874 @default.
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• W4376603154 cites W2328990582 @default.
• W4376603154 cites W2401611360 @default.
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• W4376603154 cites W2751143979 @default.
• W4376603154 cites W2775794484 @default.
• W4376603154 cites W2790215059 @default.
• W4376603154 cites W2793483855 @default.
• W4376603154 cites W2800396191 @default.
• W4376603154 cites W2900593579 @default.
• W4376603154 cites W2905259002 @default.
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• W4376603154 doi "https://doi.org/10.1109/tnsre.2023.3276431" @default.
• W4376603154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37186528" @default.
• W4376603154 hasPublicationYear "2023" @default.
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