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- W4376604224 abstract "Abstract Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it remains poorly understood which cellular and molecular components contribute to the formation of ECM stroma in central nervous system (CNS) tumors. Here, we undertook a pan-CNS analysis of retrospective gene expression datasets to characterize inter- and intra-tumoral heterogeneity of ECM remodeling signatures in both adult and pediatric CNS disease. We found that CNS lesions – glioblastoma in particular – can be divided into two ECM-based subtypes (ECM hi and ECM lo ) that are influenced by the presence of perivascular cells resembling cancer-associated fibroblasts (CAFs). We show that perivascular fibroblasts activate chemoattractant signaling pathways to recruit tumor-associated macrophages, and promote an immune-evasive, stem-like cancer cell phenotype. Our analysis reveals that perivascular fibroblasts are correlated with unfavorable response to immune checkpoint blockade in glioblastoma and poor patient survival across a subset of CNS tumors. We provide insights into novel stroma-driven mechanisms underlying immune evasion and immunotherapy resistance in CNS tumors like glioblastoma, and discuss how targeting these perivascular fibroblasts may prove an effective approach to improving treatment response and patient survival in a variety of CNS tumors." @default.
- W4376604224 created "2023-05-17" @default.
- W4376604224 creator A5003972456 @default.
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- W4376604224 creator A5073163924 @default.
- W4376604224 date "2023-05-15" @default.
- W4376604224 modified "2023-09-24" @default.
- W4376604224 title "Pan-cancer transcriptomic analysis of CNS tumor stroma identifies a population of perivascular fibroblasts that predict poor immunotherapy response in glioblastoma patients" @default.
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- W4376604224 doi "https://doi.org/10.21203/rs.3.rs-2931886/v1" @default.
- W4376604224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37292803" @default.
- W4376604224 hasPublicationYear "2023" @default.
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