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• W4376604477 abstract "Abstract Objective: Patients with oral and maxillofacial flap reconstruction often need clinical blood transfusion treatment due to massive blood loss. With the increasing limitations of allogeneic blood transfusion (ABT), acute normovolemic hemodilution (ANH) is being considered by doctors because of its advantages. By comparing the differences in blood index changes and postoperative complications of patients receiving ABT or ANH during reconstruction and repair of oral and maxillofacial tumor flaps, the purpose is to provide a reference for the clinical application of ANH. Methods: The clinical data of 276 patients who received oral and maxillofacial flap reconstruction from September 25, 2017, to October 11, 2021, in the Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, were retrospectively analyzed. According to the mode of intraoperative blood transfusion, the patients were divided into the ABT group and the ANH group. The differences in blood indexes change and the incidence of postoperative complications between two groups were statistically analyzed. Results: Of the 276 patients with ANH (124/276) and ABT (152/276), there were no differences in Δ Hb, Δ PT, Δ FIB (P>0.05), while Δ WBC, Δ PLT, Δ APTT and Δ D-dimer were significantly different (P<0.05). The data analysis showed that blood transfusion method wasn’t an independent factor of flap crisis (P>0.05), post-PT (OR=1.953, 95% CI: 1.232~3.095, P=0.004) was an independent factor of wound infection, BMI (OR=0.089, 95% CI: 0.017~0.462) and ASA grade (OR=6.373, 95% CI: 1.681~24.163) were independent factors of lung infection (P<0.05), and blood transfusion mode (B=0.310, β=0.360, P<0.001, ANH: ln hospital stay=2.20±0.37, ABT: ln hospital stay=2.54±0.42) was an independent factor affecting the length of hospital stay. Conclusion: Both preoperative and postoperative blood transfusion Δ Hb, Δ PT, and Δ FIB were not different, and Δ WBC, Δ PLT, Δ APTT, and Δ D-dimer were different. There was no difference in the effects of the two blood transfusion methods on flap crisis, incision infection and lung infection after flap reconstruction, but ANH resulted in shortening by an average of 3.65 days of hospital stay compared to ABT." @default.
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• W4376604477 date "2023-05-15" @default.
• W4376604477 modified "2023-09-24" @default.
• W4376604477 title "Effects of acute normovolemic hemodilution and allogeneic blood transfusion on postoperative complications of oral and maxillofacial flap reconstruction：a retrospective study" @default.
• W4376604477 doi "https://doi.org/10.21203/rs.3.rs-2890320/v1" @default.
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