FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376604908> ?p ?o ?g. }

• W4376604908 endingPage "166755" @default.
• W4376604908 startingPage "166755" @default.
• W4376604908 abstract "Renal fibrosis (RF) is a common pathway leading to chronic kidney disease (CKD), which lacks effective treatment. While estrogen receptor beta (ERβ) is known to be present in the kidney, its role in RF remains unclear. The present study aimed to investigate the role and underlying mechanism of ERβ during RF progression in patients and animal models with CKD. We found that ERβ was highly expressed in the proximal tubular epithelial cells (PTECs) in healthy kidneys but its expression was largely lost in patients with immunoglobin A nephropathy (IgAN) and in mice with unilateral ureter obstruction (UUO) and subtotal nephrectomy (5/6Nx). ERβ deficiency markedly exacerbated, whereas ERβ activation by WAY200070 and DPN attenuated RF in both UUO and 5/6Nx mouse models, suggesting a protective role of ERβ in RF. In addition, ERβ activation inhibited TGF-β1/Smad3 signaling, while loss of renal ERβ was associated with overactivation of the TGF-β1/Smad3 pathway. Furthermore, deletion or pharmacological inhibition of Smad3 prevented the loss of ERβ and RF. Mechanistically, activation of ERβ competitively inhibited the association of Smad3 with the Smad-binding element, thereby downregulating the transcription of the fibrosis-related genes without altering Smad3 phosphorylation in vivo and in vitro. In conclusion, ERβ exerts a renoprotective role in CKD by blocking the Smad3 signaling pathway. Thus, ERβ may represent as a promising therapeutic agent for RF." @default.
• W4376604908 created "2023-05-17" @default.
• W4376604908 creator A5001503225 @default.
• W4376604908 creator A5010558103 @default.
• W4376604908 creator A5023318710 @default.
• W4376604908 creator A5025299197 @default.
• W4376604908 creator A5026631328 @default.
• W4376604908 creator A5027181760 @default.
• W4376604908 creator A5038249152 @default.
• W4376604908 creator A5041849158 @default.
• W4376604908 creator A5043652524 @default.
• W4376604908 creator A5057620126 @default.
• W4376604908 creator A5058712148 @default.
• W4376604908 creator A5061472855 @default.
• W4376604908 creator A5061553387 @default.
• W4376604908 creator A5062302119 @default.
• W4376604908 creator A5074734978 @default.
• W4376604908 creator A5085801141 @default.
• W4376604908 creator A5086875518 @default.
• W4376604908 creator A5088089118 @default.
• W4376604908 creator A5090499433 @default.
• W4376604908 creator A5090935475 @default.
• W4376604908 date "2023-08-01" @default.
• W4376604908 modified "2023-10-03" @default.
• W4376604908 title "Estrogen receptor β attenuates renal fibrosis by suppressing the transcriptional activity of Smad3" @default.
• W4376604908 cites W1968002331 @default.
• W4376604908 cites W1970024336 @default.
• W4376604908 cites W1974055872 @default.
• W4376604908 cites W1999007536 @default.
• W4376604908 cites W2022901857 @default.
• W4376604908 cites W2030148120 @default.
• W4376604908 cites W2042087675 @default.
• W4376604908 cites W2044603199 @default.
• W4376604908 cites W2052054447 @default.
• W4376604908 cites W2058470362 @default.
• W4376604908 cites W2076732247 @default.
• W4376604908 cites W2079743814 @default.
• W4376604908 cites W2082064933 @default.
• W4376604908 cites W2088551072 @default.
• W4376604908 cites W2092377212 @default.
• W4376604908 cites W2099112129 @default.
• W4376604908 cites W2104274897 @default.
• W4376604908 cites W2110886621 @default.
• W4376604908 cites W2119218375 @default.
• W4376604908 cites W2123295328 @default.
• W4376604908 cites W2140850097 @default.
• W4376604908 cites W2149030597 @default.
• W4376604908 cites W2159444491 @default.
• W4376604908 cites W2163056783 @default.
• W4376604908 cites W2170783508 @default.
• W4376604908 cites W2293429217 @default.
• W4376604908 cites W2315771482 @default.
• W4376604908 cites W2342679639 @default.
• W4376604908 cites W2470481127 @default.
• W4376604908 cites W2938833191 @default.
• W4376604908 cites W2967279669 @default.
• W4376604908 cites W3110594937 @default.
• W4376604908 cites W3118994516 @default.
• W4376604908 doi "https://doi.org/10.1016/j.bbadis.2023.166755" @default.
• W4376604908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37196860" @default.
• W4376604908 hasPublicationYear "2023" @default.
• W4376604908 type Work @default.
• W4376604908 citedByCount "0" @default.
• W4376604908 crossrefType "journal-article" @default.
• W4376604908 hasAuthorship W4376604908A5001503225 @default.
• W4376604908 hasAuthorship W4376604908A5010558103 @default.
• W4376604908 hasAuthorship W4376604908A5023318710 @default.
• W4376604908 hasAuthorship W4376604908A5025299197 @default.
• W4376604908 hasAuthorship W4376604908A5026631328 @default.
• W4376604908 hasAuthorship W4376604908A5027181760 @default.
• W4376604908 hasAuthorship W4376604908A5038249152 @default.
• W4376604908 hasAuthorship W4376604908A5041849158 @default.
• W4376604908 hasAuthorship W4376604908A5043652524 @default.
• W4376604908 hasAuthorship W4376604908A5057620126 @default.
• W4376604908 hasAuthorship W4376604908A5058712148 @default.
• W4376604908 hasAuthorship W4376604908A5061472855 @default.
• W4376604908 hasAuthorship W4376604908A5061553387 @default.
• W4376604908 hasAuthorship W4376604908A5062302119 @default.
• W4376604908 hasAuthorship W4376604908A5074734978 @default.
• W4376604908 hasAuthorship W4376604908A5085801141 @default.
• W4376604908 hasAuthorship W4376604908A5086875518 @default.
• W4376604908 hasAuthorship W4376604908A5088089118 @default.
• W4376604908 hasAuthorship W4376604908A5090499433 @default.
• W4376604908 hasAuthorship W4376604908A5090935475 @default.
• W4376604908 hasConcept C121608353 @default.
• W4376604908 hasConcept C126322002 @default.
• W4376604908 hasConcept C134018914 @default.
• W4376604908 hasConcept C170493617 @default.
• W4376604908 hasConcept C2777164284 @default.
• W4376604908 hasConcept C2780091579 @default.
• W4376604908 hasConcept C2780559512 @default.
• W4376604908 hasConcept C2781080636 @default.
• W4376604908 hasConcept C502942594 @default.
• W4376604908 hasConcept C530470458 @default.
• W4376604908 hasConcept C62478195 @default.
• W4376604908 hasConcept C71924100 @default.
• W4376604908 hasConcept C84606932 @default.
• W4376604908 hasConcept C86803240 @default.

• next