FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376608503> ?p ?o ?g. }

• W4376608503 endingPage "112963" @default.
• W4376608503 startingPage "112963" @default.
• W4376608503 abstract "The present study attempted for the first time to explore the effects of the daily oral intake of a phenolics-rich extract from chestnut shells (CS) on the metabolomic profiling of rat tissues by liquid chromatography coupled to Orbitrap-mass spectrometry (LC-ESI-LTQ-Orbitrap-MS) targeted to polyphenolics and their metabolites and screen potential oxidative stress biomarkers, validating its use as a promising nutraceutical ingredient with outstanding antioxidant properties for the prevention and co-therapy of lifestyle-related diseases triggered by oxidative stress. The results demonstrated new insights into the metabolomic fingerprinting of polyphenols from CS, confirming their absorption and biotransformation by phase I (hydrogenation) and II (glucuronidation, methylation, and sulfation) enzymes. Phenolic acids were the main polyphenolic class, followed by hydrolyzable tannins, flavanols, and lignans. In contrast to the liver, sulfated conjugates were the principal metabolites reaching the kidneys. The multivariate data analysis predicted an exceptional contribution of polyphenols and their microbial and phase II metabolites to the in-vivo antioxidant response of the CS extract in rats, recommending its use as an appealing source of anti-aging molecules for nutraceuticals. This is the first study that explored the relation between metabolomic profiling of rat tissues and in-vivo antioxidant effects after oral treatment with a phenolics-rich CS extract." @default.
• W4376608503 created "2023-05-17" @default.
• W4376608503 creator A5001955485 @default.
• W4376608503 creator A5009912081 @default.
• W4376608503 creator A5010752968 @default.
• W4376608503 creator A5013971426 @default.
• W4376608503 creator A5029587710 @default.
• W4376608503 creator A5041458969 @default.
• W4376608503 creator A5050723667 @default.
• W4376608503 creator A5055022776 @default.
• W4376608503 date "2023-08-01" @default.
• W4376608503 modified "2023-10-18" @default.
• W4376608503 title "Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study" @default.
• W4376608503 cites W1824913618 @default.
• W4376608503 cites W2017253183 @default.
• W4376608503 cites W2027298703 @default.
• W4376608503 cites W2028650129 @default.
• W4376608503 cites W2046919127 @default.
• W4376608503 cites W2071304596 @default.
• W4376608503 cites W2094873385 @default.
• W4376608503 cites W2170908244 @default.
• W4376608503 cites W2189476982 @default.
• W4376608503 cites W2335264184 @default.
• W4376608503 cites W2532797789 @default.
• W4376608503 cites W2559611512 @default.
• W4376608503 cites W2562776611 @default.
• W4376608503 cites W2582852823 @default.
• W4376608503 cites W2728780251 @default.
• W4376608503 cites W2946830692 @default.
• W4376608503 cites W2974858909 @default.
• W4376608503 cites W2984106864 @default.
• W4376608503 cites W2995098097 @default.
• W4376608503 cites W3013083756 @default.
• W4376608503 cites W3031124187 @default.
• W4376608503 cites W3033167612 @default.
• W4376608503 cites W3040983732 @default.
• W4376608503 cites W3044083461 @default.
• W4376608503 cites W3099324918 @default.
• W4376608503 cites W3099627581 @default.
• W4376608503 cites W3119307465 @default.
• W4376608503 cites W3134585269 @default.
• W4376608503 cites W3135087001 @default.
• W4376608503 cites W3152741895 @default.
• W4376608503 cites W3157092249 @default.
• W4376608503 cites W3164281142 @default.
• W4376608503 cites W3176588968 @default.
• W4376608503 cites W3186977129 @default.
• W4376608503 cites W4213290949 @default.
• W4376608503 cites W4220876362 @default.
• W4376608503 cites W4282929178 @default.
• W4376608503 cites W4303520499 @default.
• W4376608503 cites W4308721994 @default.
• W4376608503 doi "https://doi.org/10.1016/j.foodres.2023.112963" @default.
• W4376608503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37316050" @default.
• W4376608503 hasPublicationYear "2023" @default.
• W4376608503 type Work @default.
• W4376608503 citedByCount "3" @default.
• W4376608503 countsByYear W43766085032023 @default.
• W4376608503 crossrefType "journal-article" @default.
• W4376608503 hasAuthorship W4376608503A5001955485 @default.
• W4376608503 hasAuthorship W4376608503A5009912081 @default.
• W4376608503 hasAuthorship W4376608503A5010752968 @default.
• W4376608503 hasAuthorship W4376608503A5013971426 @default.
• W4376608503 hasAuthorship W4376608503A5029587710 @default.
• W4376608503 hasAuthorship W4376608503A5041458969 @default.
• W4376608503 hasAuthorship W4376608503A5050723667 @default.
• W4376608503 hasAuthorship W4376608503A5055022776 @default.
• W4376608503 hasBestOaLocation W43766085031 @default.
• W4376608503 hasConcept C135870905 @default.
• W4376608503 hasConcept C150903083 @default.
• W4376608503 hasConcept C155138218 @default.
• W4376608503 hasConcept C162356407 @default.
• W4376608503 hasConcept C17857428 @default.
• W4376608503 hasConcept C181199279 @default.
• W4376608503 hasConcept C185592680 @default.
• W4376608503 hasConcept C207001950 @default.
• W4376608503 hasConcept C21565614 @default.
• W4376608503 hasConcept C2776151105 @default.
• W4376608503 hasConcept C2778004101 @default.
• W4376608503 hasConcept C2779907587 @default.
• W4376608503 hasConcept C2780589914 @default.
• W4376608503 hasConcept C2780841973 @default.
• W4376608503 hasConcept C31903555 @default.
• W4376608503 hasConcept C43617362 @default.
• W4376608503 hasConcept C55493867 @default.
• W4376608503 hasConcept C70899900 @default.
• W4376608503 hasConcept C86803240 @default.
• W4376608503 hasConcept C87644729 @default.
• W4376608503 hasConceptScore W4376608503C135870905 @default.
• W4376608503 hasConceptScore W4376608503C150903083 @default.
• W4376608503 hasConceptScore W4376608503C155138218 @default.
• W4376608503 hasConceptScore W4376608503C162356407 @default.
• W4376608503 hasConceptScore W4376608503C17857428 @default.
• W4376608503 hasConceptScore W4376608503C181199279 @default.
• W4376608503 hasConceptScore W4376608503C185592680 @default.
• W4376608503 hasConceptScore W4376608503C207001950 @default.
• W4376608503 hasConceptScore W4376608503C21565614 @default.
• W4376608503 hasConceptScore W4376608503C2776151105 @default.

• next