Matches in SemOpenAlex for { <https://semopenalex.org/work/W4376609436> ?p ?o ?g. }
- W4376609436 endingPage "718" @default.
- W4376609436 startingPage "718" @default.
- W4376609436 abstract "Fetuses in women with gestational diabetes (GD) compared with those without GD show evidence of subclinical cardiac functional and morphological changes. However, it is uncertain whether glycemia or the adverse maternal underlying risk factor profile is the main driver for fetal cardiac remodeling.To assess cardiac morphology and function at midgestation in fetuses of mothers prior to development of GD and compare them with those of unaffected controls.During this prospective nonintervention screening study at 19 to 23 weeks' gestation, fetal cardiac morphology and function were assessed in all participants. Pregnancy complications were obtained from the medical records of the women. Fetal cardiac morphology and function were assessed in all participants at Harris Birthright Research Institute at King's College Hospital, London, United Kingdom. Participants included pregnant women with singleton pregnancy who attended their routine fetal ultrasound examination at midgestation and agreed to participate in the Advanced Cardiovascular Imaging Study in pregnancy.Comparison of fetal cardiac morphology and function between mothers who subsequently developed GD and those who did not develop GD.This was a prospective nonintervention screening study of 5620 women with singleton pregnancies at 19 to 23 weeks' gestation. Conventional and more advanced echocardiographic modalities, such as speckle tracking, were used to assess fetal cardiac function in the right and left ventricle. The morphology of the fetal heart was assessed by calculating the right and left sphericity index.The 5620 included patients had a mean age of 33.6 years. In 470 cases, the women were diagnosed with GD after the midgestation echocardiographic assessment (8.4%). Women with GD, compared with the non-GD group, were older, had higher BMI, higher prevalence of family history of diabetes, non-White ethnicity, chronic hypertension, and GD in a previous pregnancy. In fetuses of the GD group compared with the non-GD group, there was mild increase in interventricular millimeter thickness (0.04; 95% CI, 0.03-0.06 mm) and left atrial area (0.04; 95% CI, 0.04-0.05), whereas left and right functional indices were comparable between groups with the exception of left ventricular ejection fraction, which was marginally improved in the GD group (0.02; 95% CI, 0.03-0.03).This study demonstrates that prior to development of GD, there was mild alteration in fetal cardiac morphology without affecting cardiac function. This suggests that the adverse maternal risk factor profile and not only the glycemia might contribute to cardiac remodeling noted in fetuses of women with GD." @default.
- W4376609436 created "2023-05-17" @default.
- W4376609436 creator A5004117088 @default.
- W4376609436 creator A5033925650 @default.
- W4376609436 creator A5064914136 @default.
- W4376609436 creator A5080220991 @default.
- W4376609436 creator A5082797679 @default.
- W4376609436 creator A5084249594 @default.
- W4376609436 date "2023-07-01" @default.
- W4376609436 modified "2023-09-29" @default.
- W4376609436 title "Fetal Cardiac Function at Midgestation in Women Who Subsequently Develop Gestational Diabetes" @default.
- W4376609436 cites W1154833837 @default.
- W4376609436 cites W2015212022 @default.
- W4376609436 cites W2046423215 @default.
- W4376609436 cites W2066761872 @default.
- W4376609436 cites W2067319578 @default.
- W4376609436 cites W2114671826 @default.
- W4376609436 cites W2156919974 @default.
- W4376609436 cites W2603176272 @default.
- W4376609436 cites W2775702235 @default.
- W4376609436 cites W2903693090 @default.
- W4376609436 cites W2909303805 @default.
- W4376609436 cites W2917958430 @default.
- W4376609436 cites W2986009663 @default.
- W4376609436 cites W2992178815 @default.
- W4376609436 cites W3000436666 @default.
- W4376609436 cites W3018084934 @default.
- W4376609436 cites W3024197685 @default.
- W4376609436 cites W3102435671 @default.
- W4376609436 cites W3177306862 @default.
- W4376609436 cites W3208833260 @default.
- W4376609436 cites W4206974003 @default.
- W4376609436 cites W4230427429 @default.
- W4376609436 cites W4234523789 @default.
- W4376609436 cites W4237149434 @default.
- W4376609436 cites W4242284796 @default.
- W4376609436 cites W4246149110 @default.
- W4376609436 cites W4246705744 @default.
- W4376609436 cites W4247941080 @default.
- W4376609436 cites W4248821554 @default.
- W4376609436 doi "https://doi.org/10.1001/jamapediatrics.2023.1174" @default.
- W4376609436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37184868" @default.
- W4376609436 hasPublicationYear "2023" @default.
- W4376609436 type Work @default.
- W4376609436 citedByCount "0" @default.
- W4376609436 crossrefType "journal-article" @default.
- W4376609436 hasAuthorship W4376609436A5004117088 @default.
- W4376609436 hasAuthorship W4376609436A5033925650 @default.
- W4376609436 hasAuthorship W4376609436A5064914136 @default.
- W4376609436 hasAuthorship W4376609436A5080220991 @default.
- W4376609436 hasAuthorship W4376609436A5082797679 @default.
- W4376609436 hasAuthorship W4376609436A5084249594 @default.
- W4376609436 hasConcept C111566952 @default.
- W4376609436 hasConcept C113280763 @default.
- W4376609436 hasConcept C126322002 @default.
- W4376609436 hasConcept C131872663 @default.
- W4376609436 hasConcept C164705383 @default.
- W4376609436 hasConcept C172680121 @default.
- W4376609436 hasConcept C188816634 @default.
- W4376609436 hasConcept C2777162553 @default.
- W4376609436 hasConcept C2778198053 @default.
- W4376609436 hasConcept C2778258057 @default.
- W4376609436 hasConcept C2778376644 @default.
- W4376609436 hasConcept C2779234561 @default.
- W4376609436 hasConcept C2779434492 @default.
- W4376609436 hasConcept C46973012 @default.
- W4376609436 hasConcept C54355233 @default.
- W4376609436 hasConcept C71924100 @default.
- W4376609436 hasConcept C86803240 @default.
- W4376609436 hasConceptScore W4376609436C111566952 @default.
- W4376609436 hasConceptScore W4376609436C113280763 @default.
- W4376609436 hasConceptScore W4376609436C126322002 @default.
- W4376609436 hasConceptScore W4376609436C131872663 @default.
- W4376609436 hasConceptScore W4376609436C164705383 @default.
- W4376609436 hasConceptScore W4376609436C172680121 @default.
- W4376609436 hasConceptScore W4376609436C188816634 @default.
- W4376609436 hasConceptScore W4376609436C2777162553 @default.
- W4376609436 hasConceptScore W4376609436C2778198053 @default.
- W4376609436 hasConceptScore W4376609436C2778258057 @default.
- W4376609436 hasConceptScore W4376609436C2778376644 @default.
- W4376609436 hasConceptScore W4376609436C2779234561 @default.
- W4376609436 hasConceptScore W4376609436C2779434492 @default.
- W4376609436 hasConceptScore W4376609436C46973012 @default.
- W4376609436 hasConceptScore W4376609436C54355233 @default.
- W4376609436 hasConceptScore W4376609436C71924100 @default.
- W4376609436 hasConceptScore W4376609436C86803240 @default.
- W4376609436 hasIssue "7" @default.
- W4376609436 hasLocation W43766094361 @default.
- W4376609436 hasLocation W43766094362 @default.
- W4376609436 hasOpenAccess W4376609436 @default.
- W4376609436 hasPrimaryLocation W43766094361 @default.
- W4376609436 hasRelatedWork W2056752164 @default.
- W4376609436 hasRelatedWork W2091864115 @default.
- W4376609436 hasRelatedWork W2093112264 @default.
- W4376609436 hasRelatedWork W2163638983 @default.
- W4376609436 hasRelatedWork W2333891256 @default.
- W4376609436 hasRelatedWork W2353304521 @default.
- W4376609436 hasRelatedWork W2390578688 @default.